Neurobiology of opiate abuse
- PMID:1604711
- DOI: 10.1016/0165-6147(92)90062-b
Neurobiology of opiate abuse
Abstract
Opiates interact with cell surface receptors on neurons involved in the transmission of information along neural pathways that are related to behaviours essential for the life of the self and of the species. Opiates are provided with powerful and multifaceted rewarding properties that are fundamental for the acquisition, maintenance and relapse of opiate addiction. Gaetano Di Chiara and Alan North argue that both dopaminergic and non-dopaminergic systems are involved in opiate reward, and that opiate addiction results from adaptive and learning processes involving both positive reinforcing mechanisms related to the rewarding properties of opiates and negative reinforcing mechanisms related to the aversive properties of withdrawal in dependent subjects.
Similar articles
- Neural mechanisms of the reinforcing action of cocaine.Wise RA.Wise RA.NIDA Res Monogr. 1984;50:15-33.NIDA Res Monogr. 1984.PMID:6440023Review.
- The neurobiology of addiction.Maldonado R.Maldonado R.J Neural Transm Suppl. 2003;(66):1-14. doi: 10.1007/978-3-7091-0541-2_1.J Neural Transm Suppl. 2003.PMID:14582800Review.
- Brain mechanisms of drug reward and euphoria.Wise RA, Bozarth MA.Wise RA, et al.Psychiatr Med. 1985;3(4):445-60.Psychiatr Med. 1985.PMID:2893431Review.
- Effects of drugs of abuse on hippocampal plasticity and hippocampus-dependent learning and memory: contributions to development and maintenance of addiction.Kutlu MG, Gould TJ.Kutlu MG, et al.Learn Mem. 2016 Sep 15;23(10):515-33. doi: 10.1101/lm.042192.116. Print 2016 Oct.Learn Mem. 2016.PMID:27634143Free PMC article.Review.
- Reward and abuse of opiates.Ramsey NF, Van Ree JM.Ramsey NF, et al.Pharmacol Toxicol. 1992 Aug;71(2):81-94. doi: 10.1111/j.1600-0773.1992.tb00525.x.Pharmacol Toxicol. 1992.PMID:1438034Review.
Cited by
- Paradoxical signal transduction in neurobiological systems.Colpaert FC, Frégnac Y.Colpaert FC, et al.Mol Neurobiol. 2001 Aug-Dec;24(1-3):145-68. doi: 10.1385/MN:24:1-3:145.Mol Neurobiol. 2001.PMID:11831550Review.
- Increased rewarding properties of morphine in dopamine-transporter knockout mice.Spielewoy C, Gonon F, Roubert C, Fauchey V, Jaber M, Caron MG, Roques BP, Hamon M, Betancur C, Maldonado R, Giros B.Spielewoy C, et al.Eur J Neurosci. 2000 May;12(5):1827-37. doi: 10.1046/j.1460-9568.2000.00063.x.Eur J Neurosci. 2000.PMID:10792459Free PMC article.
- Treatment of neonatal abstinence syndrome.Johnson K, Gerada C, Greenough A.Johnson K, et al.Arch Dis Child Fetal Neonatal Ed. 2003 Jan;88(1):F2-5. doi: 10.1136/fn.88.1.f2.Arch Dis Child Fetal Neonatal Ed. 2003.PMID:12496218Free PMC article.Review.
- Insulin receptor substrate-2 in the ventral tegmental area regulates behavioral responses to cocaine.Iñiguez SD, Warren BL, Neve RL, Nestler EJ, Russo SJ, Bolaños-Guzmán CA.Iñiguez SD, et al.Behav Neurosci. 2008 Oct;122(5):1172-7. doi: 10.1037/a0012893.Behav Neurosci. 2008.PMID:18823173Free PMC article.
- DAKB-GPCRs: An Integrated Computational Platform for Drug Abuse Related GPCRs.Chen M, Jing Y, Wang L, Feng Z, Xie XQ.Chen M, et al.J Chem Inf Model. 2019 Apr 22;59(4):1283-1289. doi: 10.1021/acs.jcim.8b00623. Epub 2019 Mar 14.J Chem Inf Model. 2019.PMID:30835466Free PMC article.
Publication types
MeSH terms
Substances
Related information
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical