doi: 10.1212/01.wnl.0000101717.16799.8f.
Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine
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- PMID:14718719
- DOI: 10.1212/01.wnl.0000101717.16799.8f
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Association between the tumor necrosis factor-alpha -308 G/A gene polymorphism and migraine
I Rainero et al. Neurology..
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Abstract
In a group of 299 migraine patients and 306 control subjects, the association of the -308 G/A polymorphism in the tumor necrosis factor-alpha gene (TNFalpha) with the occurrence and clinical characteristics of migraine was tested. Homozygosity for the G allele was associated with an increased risk of migraine (odds ratio [OR] = 2.85, p < 0.001). When the patients were divided into subgroups, the association was confirmed in patients affected by migraine without aura (OR = 3.30, p < 0.001) but not in migraine with aura. These data suggest that the TNFalpha gene or a linked locus significantly modulates the risk for migraine.
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