Review
doi: 10.1038/ni1102-991.Cancer immunoediting: from immunosurveillance to tumor escape
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- PMID:12407406
- DOI: 10.1038/ni1102-991
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Review
Cancer immunoediting: from immunosurveillance to tumor escape
Gavin P Dunn et al. Nat Immunol.2002 Nov.
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Abstract
The concept that the immune system can recognize and destroy nascent transformed cells was originally embodied in the cancer immunosurveillance hypothesis of Burnet and Thomas. This hypothesis was abandoned shortly afterwards because of the absence of strong experimental evidence supporting the concept. New data, however, clearly show the existence of cancer immunosurveillance and also indicate that it may function as a component of a more general process of cancer immunoediting. This process is responsible for both eliminating tumors and sculpting the immunogenic phenotypes of tumors that eventually form in immunocompetent hosts. In this review, we will summarize the historical and experimental basis of cancer immunoediting and discuss its dual roles in promoting host protection against cancer and facilitating tumor escape from immune destruction.
Comment in
- Observing the invisible: successful tumor immunity in humans.Darnell RB, Posner JB.Darnell RB, et al.Nat Immunol. 2003 Mar;4(3):201. doi: 10.1038/ni0303-201.Nat Immunol. 2003.PMID:12605223No abstract available.
- A cancer immunosurveillance controversy.Qin Z, Blankenstein T.Qin Z, et al.Nat Immunol. 2004 Jan;5(1):3-4; author reply 4-5. doi: 10.1038/ni0104-3.Nat Immunol. 2004.PMID:14699396No abstract available.
- Halo naevus: a visible case of immunosurveillance in humans?Cui Z, Willingham MC.Cui Z, et al.Lancet Oncol. 2004 Jul;5(7):397-8. doi: 10.1016/S1470-2045(04)01505-0.Lancet Oncol. 2004.PMID:15231244No abstract available.
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