| Entry | |
|---|
| Name | Thonzylamine (INN);
Tonamil (TN) |
|---|
| Formula | C16H22N4O
|
|---|
| Exact mass | 286.1794
|
|---|
| Mol weight | 286.37
|
|---|
| Structure | 
|
|---|
| Simcomp | |
|---|
| Class | Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
|
|---|
| Remark | |
|---|
| Efficacy | Antiallergic, H1 receptor antagonist |
|---|
| Comment | Phenbenzamine derivative
|
|---|
| Target | |
|---|
| Pathway | | hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction | |
|---|
| Structure map | | map07212 | Histamine H1 receptor antagonists |
|
|---|
| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
D04AA Antihistamines for topical use
D04AA01 Thonzylamine
D08587 Thonzylamine (INN)
R RESPIRATORY SYSTEM
R01 NASAL PREPARATIONS
R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
R01AC Antiallergic agents, excl. corticosteroids
R01AC06 Thonzylamine
D08587 Thonzylamine (INN)
R06 ANTIHISTAMINES FOR SYSTEMIC USE
R06A ANTIHISTAMINES FOR SYSTEMIC USE
R06AC Substituted ethylene diamines
R06AC06 Thonzylamine
D08587 Thonzylamine (INN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Thonzylamine
D08587 Thonzylamine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00381 Thonzylamine
D08587 Thonzylamine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH1
D08587 Thonzylamine (INN)
Drug groups [BR:br08330]
Anti-allergic agent
DG01557 Histamine receptor antagonist
DG01482 Histamine receptor H1 antagonist
DG00381 Thonzylamine
|
|---|
| Other DBs | |
|---|
| LinkDB | |
|---|
| KCF data |
ATOM 21
1 N5x N 19.7400 -22.4000
2 C8x C 19.7400 -23.8000
3 C8x C 20.9524 -24.5000
4 C8x C 22.1649 -23.8000
5 N5x N 22.1649 -22.4000
6 C8y C 20.9524 -21.7000
7 N1c N 20.9524 -20.3002
8 C1b C 19.7232 -19.5903
9 C1b C 22.1480 -19.6098
10 C8y C 18.5192 -20.2854
11 C8x C 17.3363 -19.6023
12 C8x C 16.1238 -20.3022
13 C8y C 16.1237 -21.7022
14 C8x C 17.3067 -22.3853
15 C8x C 18.5191 -21.6854
16 O2a O 14.8945 -22.4119
17 C1a C 13.6886 -21.7157
18 C1b C 23.3352 -20.2952
19 N1c N 24.5266 -19.6072
20 C1a C 25.7159 -20.2939
21 C1a C 24.5267 -18.2003
BOND 22
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 7 8 1
9 7 9 1
10 8 10 1
11 10 11 2
12 11 12 1
13 12 13 2
14 13 14 1
15 14 15 2
16 10 15 1
17 13 16 1
18 16 17 1
19 9 18 1
20 18 19 1
21 19 20 1
22 19 21 1
|
|---|
