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Clec10aGene Detail

Summary

Symbol
Clec10a
Name
C-type lectin domain family 10, member A
Synonyms
CD301a, Mgl1

Feature Type
protein coding gene
IDs
MGI:96975
NCBI Gene:17312
Alliance
gene page
Transcription Start Sites
5 TSS

Location &
Maps

Sequence Map
Chr11:70057449-70061662 bp, + strand
From NCBI annotation of GRCm39
View this region inJBrowse
Genome Browsers
Ensembl |UCSC |NCBI

Genetic Map
Chromosome 11, 42.99 cM
Mapping Data
3 experiments

Strain
Comparison

SNPs within 2kb
128from dbSNP Build 142
Strain Annotations
15
RFLP
1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96975	protein coding gene	Chr11:70047023-70061662 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018583	protein coding gene	Chr11:70675868-70685635 (+)
A/J	MGP_AJ_G0018551	protein coding gene	Chr11:67992607-67998085 (+)
AKR/J	MGP_AKRJ_G0018520	protein coding gene	Chr11:70027151-70033138 (+)
BALB/cJ	MGP_BALBcJ_G0018523	protein coding gene	Chr11:68320165-68324516 (+)
C3H/HeJ	no annotation
C57BL/6NJ	MGP_C57BL6NJ_G0018974	protein coding gene	Chr11:72758124-72789445 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016619	protein coding gene	Chr11:64915420-64921817 (+)
CAST/EiJ	MGP_CASTEiJ_G0017891	protein coding gene	Chr11:70283436-70315525 (+)
CBA/J	no annotation
DBA/2J	MGP_DBA2J_G0018418	protein coding gene	Chr11:67573403-67578621 (+)
FVB/NJ	MGP_FVBNJ_G0018408	protein coding gene	Chr11:67227544-67231925 (+)
LP/J	MGP_LPJ_G0018488	protein coding gene	Chr11:71249992-71253864 (+)
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0019016	protein coding gene	Chr11:70296455-70300103 (+)
PWK/PhJ	MGP_PWKPhJ_G0017665	protein coding gene	Chr11:68202121-68231318 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017455	protein coding gene	Chr11:70092599-70097035 (+)
WSB/EiJ	MGP_WSBEiJ_G0017945	protein coding gene	Chr11:69960071-69964610 (+)

Homology

Human Ortholog
CLEC10A, C-type lectin domain containing 10A

Vertebrate Orthologs
4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
CLEC10A,C-type lectin domain containing 10A
Synonyms
CD301, CLECSF13, CLECSF14, HML, HML2, MGL
Links
HGNC:16916
NCBI Gene ID:10462
neXtProt AC:NX_Q8IUN9
UniProt:Q8IUN9
Chr Location
17p13.1; chr17:7074537-7080307(-) GRCh38

MGI Vertebrate Homology
Clec10a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP
vertebrate homology predictions:CLEC10A
Gene Tree
Clec10a

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
11 phenotypesfrom 2 allelesin 2 genetic backgrounds
1 phenotype from multigenic genotypes
31 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
15
Chemically induced (other)
1
Endonuclease-mediated
7
Spontaneous
1
Targeted
5
Transgenic
1
Genomic Mutations
3 involving Clec10a
Find Mice (IMSR)
23 strains or lines available
Comparison Matrix
Gene Expression + Phenotype

Homozygotes for a targeted null mutation exhibit elevated red blood cell counts but appear to be otherwise normal. Homozygosity for the p.Q236* mutation affects cell surface expression and leads to hypersensitivity to house dust mites.

Gene Ontology
(GO)
Classifications

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All GO Annotations
10
GO References
4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
754
Tissues
41
cDNA Data
26
Literature Summary
3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links
Allen Institute
GEO
Expression Atlas
Other Vertebrate Links
Xenbaseclec10a

Sequences &
Gene Models

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All Sequences
55
RefSeq
6
UniProt
8
CCDS
CCDS24936.1,CCDS56784.1

Ensembl
ENSMUSG00000000318 (Evidence)
NCBI Gene
17312

			Length	Strain/Species	Flank
genomic	17312	NCBI Gene Model \|MGI Sequence Detail	4214	C57BL/6J	± kb
transcript	NM_001204252	RefSeq \|MGI Sequence Detail	1468	C57BL/6
polypeptide	P49300	UniProt \|EBI \|MGI Sequence Detail	304	Not Applicable

Protein
Information

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UniProt
8 Sequences
Protein Ontology
PR:000001410 C-type lectin domain family 10 member A
(term hierarchy)
InterPro Domains
IPR033989 CD209-like, C-type lectin-like domain
IPR050111 C-type lectin and snaclec domain-containing protein
IPR018378 C-type lectin, conserved site
IPR016187 C-type lectin fold
IPR001304 C-type lectin-like
IPR016186 C-type lectin-like/link domain superfamily
IPR051379 C-type Lectin Receptor Immune Modulators
GlyGen
P49300 2 sites

Molecular
Reagents

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All nucleic28
cDNA27
Primer pair1

Microarray probesets3

Other
Accession IDs

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MGD-MRK-12220

References

Summaries
All64
Developmental Gene Expression3
Gene Ontology4
Phenotypes31
Earliest
J:5439 Bannerman RM, et al., Hereditary disorders of the red cell in animals. Prog Hematol. 1973;8:131-79
Latest
J:362669 Ward SE, et al., Macrophage Galactose Lectin Contributes to the Regulation of FVIII (Factor VIII) Clearance in Mice-Brief Report. Arterioscler Thromb Vasc Biol. 2023 Apr;43(4):540-546

TSS for Clec10a:

(View these features inJBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr102659	Chr11:70057474-70057489 (+)	33 bp
Tssr102660	Chr11:70057522-70057533 (+)	79 bp
Tssr102661	Chr11:70057592-70057610 (+)	152 bp
Tssr102662	Chr11:70058010-70058024 (+)	568 bp
Tssr102663	Chr11:70058028-70058048 (+)	589 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24

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