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Itgb7Gene Detail
Summary
  • Symbol
    Itgb7
  • Name
    integrin beta 7
  • Feature Type
    protein coding gene
  • IDs
    MGI:96616
    NCBI Gene:16421
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102124430-102140379 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 57.39 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    516from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6Jno annotation
129S1/SvImJMGP_129S1SvImJ_G0022404
protein coding geneChr15:104372124-104388008 (-)
A/JMGP_AJ_G0022366
protein coding geneChr15:100275409-100291340 (-)
AKR/JMGP_AKRJ_G0022341
protein coding geneChr15:103307409-103323364 (-)
BALB/cJMGP_BALBcJ_G0022370
protein coding geneChr15:100319821-100335637 (-)
C3H/HeJMGP_C3HHeJ_G0022137
protein coding geneChr15:103384982-103400628 (-)
C57BL/6NJMGP_C57BL6NJ_G0022819
protein coding geneChr15:108252041-108268021 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0020342
protein coding geneChr15:96051771-96068307 (-)
CAST/EiJMGP_CASTEiJ_G0021663
protein coding geneChr15:104246029-104265887 (-)
CBA/JMGP_CBAJ_G0022106
protein coding geneChr15:112047487-112063439 (-)
DBA/2JMGP_DBA2J_G0022237
protein coding geneChr15:99563519-99579579 (-)
FVB/NJMGP_FVBNJ_G0022213
protein coding geneChr15:98624471-98640481 (-)
LP/JMGP_LPJ_G0022306
protein coding geneChr15:104534259-104550230 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0022235
protein coding geneChr15:115626819-115642752 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0022831
protein coding geneChr15:103333379-103350522 (-)
PWK/PhJMGP_PWKPhJ_G0021403
protein coding geneChr15:99713722-99730023 (-)
SPRET/EiJMGP_SPRETEiJ_G0021235
protein coding geneChr15:103183972-103199835 (-)
WSB/EiJMGP_WSBEiJ_G0021713
protein coding geneChr15:103966466-103982352 (-)



Homology
more
  • Human Ortholog
    ITGB7, integrin subunit beta 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ITGB7,integrin subunit beta 7
  • Links
    NCBI Gene ID:3695
    neXtProt AC:NX_P26010
    UniProt:P26010

  • Chr Location
    12q13.13; chr12:53191323-53207282(-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypesfrom 2 allelesin 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    92 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display hypoplasia of gut-associated lymph tissue due to defects in lymphocyte migration
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000001281Ensembl Gene Model |MGI Sequence Detail15950C57BL/6J± kb
transcriptENSMUST00000001327Ensembl |MGI Sequence Detail2683Not Applicable 
polypeptideENSMUSP00000001327Ensembl |MGI Sequence Detail806Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic35
    Genomic3
    cDNA32

    Microarray probesets4
Other
Accession IDs
less
MGD-MRK-11495
References
more
  • Summaries
    All152
    Developmental Gene Expression6
    Diseases1
    Gene Ontology7
    Phenotypes92
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:358449 Li Y, et al., Mucosal Addressin Cell Adhesion Molecule-1 Mediates T Cell Migration into Pancreas-Draining Lymph Nodes for Initiation of the Autoimmune Response in Type 1 Diabetes. Int J Mol Sci. 2024 Oct 22;25(21)
TSS for Itgb7:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr136667Chr15:102140355-102140376 (-)13 bp
Tssr136666Chr15:102140330-102140352 (-)38 bp
Tssr136665Chr15:102132928-102132938 (-)7,446 bp
Tssr136664Chr15:102132895-102132900 (-)7,481 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
12/10/2024
MGI 6.24		The Jackson Laboratory
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