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Htr1bGene Detail
Summary
  • Symbol
    Htr1b
  • Name
    5-hydroxytryptamine (serotonin) receptor 1B
  • Synonyms
    5-HT1B receptor, 5-HT1B receptor, 5HT1B receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:96274
    NCBI Gene:15551
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:81510344-81515881 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 44.61 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    191from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_96274
protein coding geneChr9:81510344-81515885 (-)
129S1/SvImJMGP_129S1SvImJ_G0035081
protein coding geneChr9:82233990-82239531 (-)
A/JMGP_AJ_G0035062
protein coding geneChr9:79365409-79371111 (-)
AKR/JMGP_AKRJ_G0034990
protein coding geneChr9:81208575-81214116 (-)
BALB/cJMGP_BALBcJ_G0035050
protein coding geneChr9:79013452-79018987 (-)
C3H/HeJMGP_C3HHeJ_G0034762
protein coding geneChr9:81771222-81781049 (-)
C57BL/6NJMGP_C57BL6NJ_G0035573
protein coding geneChr9:84481439-84486954 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0032481
protein coding geneChr9:78421643-78427152 (-)
CAST/EiJMGP_CASTEiJ_G0034080
protein coding geneChr9:82156935-82162464 (-)
CBA/JMGP_CBAJ_G0034735
protein coding geneChr9:87445498-87455909 (-)
DBA/2JMGP_DBA2J_G0034893
protein coding geneChr9:78993650-78999177 (-)
FVB/NJMGP_FVBNJ_G0034836
protein coding geneChr9:78146456-78151991 (-)
LP/JMGP_LPJ_G0034974
protein coding geneChr9:82431769-82437310 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0034878
protein coding geneChr9:88749371-88754890 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0035594
protein coding geneChr9:81455109-81460638 (-)
PWK/PhJMGP_PWKPhJ_G0033784
protein coding geneChr9:79165834-79171419 (-)
SPRET/EiJMGP_SPRETEiJ_G0033620
protein coding geneChr9:81583557-81589090 (-)
WSB/EiJMGP_WSBEiJ_G0034197
protein coding geneChr9:81389191-81394712 (-)



Homology
more
  • Human Ortholog
    HTR1B, 5-hydroxytryptamine receptor 1B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR1B,5-hydroxytryptamine receptor 1B
  • Synonyms
    5-HT-1B, 5-HT1B, 5-HT1DB, 5-HT-1D-beta, HTR1D2, HTR1DB, S12
  • Links
    NCBI Gene ID:3351
    UniProt:P28222

  • Chr Location
    6q14.1; chr6:77460924-77463491(-)  GRCh38
Human Diseases
more
  • Diseases
    9 with human HTR1B associations

Human DiseaseMouse Models
    
IDs
alcohol dependence      
IDs
alcohol use disorder      

DOID:1574
ICD10CM:F10.1
ICD9CM:305.0
ICD9CM:305.00
MESH:D000437
NCI:C20701
UMLS_CUI:C0085762

IDs
antisocial personality disorder      

DOID:10939
ICD10CM:F60.2
ICD9CM:301.7
MESH:D000987
NCI:C88413
UMLS_CUI:C0003431

IDs
attention deficit hyperactivity disorder      
IDs
conduct disorder      

DOID:12995
EFO:0004216
ICD10CM:F91
ICD9CM:312.9
MESH:D019955
NCI:C89329
UMLS_CUI:C0149654

IDs
generalized anxiety disorder      

DOID:14320
ICD10CM:F41.1
ICD9CM:300.02
NCI:C92622
UMLS_CUI:C0270549

IDs
major depressive disorder      

DOID:1470
DOID:10614
DOID:2240
DOID:2241
DOID:7580
ICD10CM:F32
ICD10CM:F33.9
ICD9CM:296.2
ICD9CM:296.20
ICD9CM:296.3
ICD9CM:296.30
NCI:C34796
OMIM:608516
OMIM:608520
OMIM:608691
UMLS_CUI:C0024517
UMLS_CUI:C0154409

IDs
nicotine dependence      
IDs
substance abuse      

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypesfrom 2 allelesin 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit an increase in body weight, aggression, drinking behavior, and osteoblast proliferation and bone mass, and show altered spatial learning and operant conditional behavior as well as reduced anxiety-related response and startle reflex, and small testes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000049511Ensembl Gene Model |MGI Sequence Detail5538C57BL/6J± kb
transcriptENSMUST00000051005Ensembl |MGI Sequence Detail1273Not Applicable 
polypeptideENSMUSP00000050898Ensembl |MGI Sequence Detail386Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic12
    Genomic1
    cDNA5
    Primer pair5
    Other1
    Antibodies1

    Microarray probesets3
Other
Accession IDs
less
MGD-MRK-11000
References
more
  • Summaries
    All157
    Developmental Gene Expression14
    Gene Ontology13
    Phenotypes82
  • Earliest
    J:43 Maroteaux L, et al., Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. Proc Natl Acad Sci U S A. 1992 Apr 1;89(7):3020-4
  • Latest
    J:375760 Gibson SE, et al., Htr1b is necessary for normal retinal function in mice. Front Cell Neurosci. 2025;19:1690447
TSS for Htr1b:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr90723Chr9:81515896-81515902 (-)-18 bp
Tssr90722Chr9:81515859-81515892 (-)5 bp
Tssr90721Chr9:81515823-81515840 (-)49 bp
Tssr90720Chr9:81515565-81515617 (-)290 bp
Tssr90719Chr9:81515495-81515500 (-)383 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
01/20/2026
MGI 6.24		The Jackson Laboratory
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