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Hoxc12Gene Detail
Summary
  • Symbol
    Hoxc12
  • Name
    homeobox C12
  • Synonyms
    Hox-3.8
  • Feature Type
    protein coding gene
  • IDs
    MGI:96194
    NCBI Gene:15421
  • Member of
    Hoxc cluster
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:102845261-102847044 bp, + strand
    From NCBI annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 15, 58.01 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    76from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_96194
protein coding geneChr15:102845192-102847044 (+)
129S1/SvImJMGP_129S1SvImJ_G0022425
protein coding geneChr15:105171008-105172869 (+)
A/JMGP_AJ_G0022387
protein coding geneChr15:101015534-101017395 (+)
AKR/JMGP_AKRJ_G0022362
protein coding geneChr15:104084755-104086600 (+)
BALB/cJMGP_BALBcJ_G0022391
protein coding geneChr15:101063149-101065010 (+)
C3H/HeJMGP_C3HHeJ_G0022158
protein coding geneChr15:104160867-104162728 (+)
C57BL/6NJMGP_C57BL6NJ_G0022840
protein coding geneChr15:109067042-109068894 (+)
CAROLI/EiJMGP_CAROLIEiJ_G0020363
protein coding geneChr15:96785073-96786926 (+)
CAST/EiJMGP_CASTEiJ_G0021684
protein coding geneChr15:105033087-105034937 (+)
CBA/JMGP_CBAJ_G0022127
protein coding geneChr15:112898305-112900166 (+)
DBA/2JMGP_DBA2J_G0022258
protein coding geneChr15:100285654-100287502 (+)
FVB/NJMGP_FVBNJ_G0022234
protein coding geneChr15:99355129-99356977 (+)
LP/JMGP_LPJ_G0022327
protein coding geneChr15:105306636-105308497 (+)
NOD/ShiLtJMGP_NODShiLtJ_G0022256
protein coding geneChr15:116414933-116416781 (+)
NZO/HlLtJMGP_NZOHlLtJ_G0022852
protein coding geneChr15:104123495-104125347 (+)
PWK/PhJMGP_PWKPhJ_G0021424
protein coding geneChr15:100464568-100466369 (+)
SPRET/EiJMGP_SPRETEiJ_G0021256
protein coding geneChr15:103953441-103955300 (+)
WSB/EiJMGP_WSBEiJ_G0021734
protein coding geneChr15:104737855-104739709 (+)



Homology
more
  • Human Ortholog
    HOXC12, homeobox C12
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXC12,homeobox C12
  • Synonyms
    HOC3F, HOX3, HOX3F
  • Links
    NCBI Gene ID:3228
    neXtProt AC:NX_P31275
    UniProt:P31275

  • Chr Location
    12q13.13; chr12:53954903-53958956(+)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypesfrom 1 allelein 1 genetic background
    34 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic15421NCBI Gene Model |MGI Sequence Detail1784C57BL/6J± kb
transcriptNM_010463RefSeq |MGI Sequence Detail962Not Specified 
polypeptideQ8K5B8UniProt |EBI |MGI Sequence Detail280Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic21
    Genomic6
    cDNA8
    Primer pair4
    Other3

    Microarray probesets1
Other
Accession IDs
less
MGD-MRK-10846, MGD-MRK-10895
References
more
  • Summaries
    All73
    Developmental Gene Expression19
    Diseases1
    Gene Ontology7
    Phenotypes34
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
TSS for Hoxc12:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr133475Chr15:102845251-102845269 (+)-1 bp
Tssr133476Chr15:102845277-102845289 (+)22 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support.		 last database update
03/25/2025
MGI 6.24		The Jackson Laboratory
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