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HlxGene Detail
Summary
  • Symbol
    Hlx
  • Name
    H2.0-like homeobox
  • Synonyms
    Hlx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96109
    NCBI Gene:15284
  • Alliance
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:184459340-184464690 bp, - strand
    From NCBI annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 88.97 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    201from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_96109
protein coding geneChr1:184459337-184464816 (-)
129S1/SvImJMGP_129S1SvImJ_G0016908
protein coding geneChr1:191402501-191408855 (-)
A/JMGP_AJ_G0016887
protein coding geneChr1:183604534-183609971 (-)
AKR/JMGP_AKRJ_G0016852
protein coding geneChr1:189009059-189014440 (-)
BALB/cJMGP_BALBcJ_G0016845
protein coding geneChr1:184234956-184244123 (-)
C3H/HeJMGP_C3HHeJ_G0016669
protein coding geneChr1:189857084-189862559 (-)
C57BL/6NJMGP_C57BL6NJ_G0017308
protein coding geneChr1:197529411-197535723 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0015015
protein coding geneChr1:174601805-174607516 (-)
CAST/EiJMGP_CASTEiJ_G0016252
protein coding geneChr1:189275290-189281817 (-)
CBA/JMGP_CBAJ_G0016643
protein coding geneChr1:204904175-204910715 (-)
DBA/2JMGP_DBA2J_G0016749
protein coding geneChr1:182365768-182371256 (-)
FVB/NJMGP_FVBNJ_G0016745
protein coding geneChr1:180465015-180470423 (-)
LP/JMGP_LPJ_G0016824
protein coding geneChr1:192571633-192577197 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0016777
protein coding geneChr1:211803569-211813888 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0017345
protein coding geneChr1:188866641-188872199 (-)
PWK/PhJMGP_PWKPhJ_G0016039
protein coding geneChr1:181561236-181566758 (-)
SPRET/EiJMGP_SPRETEiJ_G0015815
protein coding geneChr1:187836782-187842144 (-)
WSB/EiJMGP_WSBEiJ_G0016314
protein coding geneChr1:189041005-189047367 (-)



Homology
more
  • Human Ortholog
    HLX, H2.0 like homeobox
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HLX,H2.0 like homeobox
  • Synonyms
    HB24, HLX1
  • Links
    NCBI Gene ID:3142
    neXtProt AC:NX_Q14774
    UniProt:Q14774

  • Chr Location
    1q41; chr1:220879431-220885059(+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypesfrom 1 allelein 3 genetic backgrounds
    1 images
    7 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disrputions in this gene die as embryos as a result of defective organogenesis and fetal hematopoiesis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic15284NCBI Gene Model |MGI Sequence Detail5351C57BL/6J± kb
transcriptNM_008250RefSeq |MGI Sequence Detail2171ZRU/MplStud 
polypeptideQ61670UniProt |EBI |MGI Sequence Detail476Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic26
    Genomic3
    cDNA22
    Primer pair1

    Microarray probesets3
Other
Accession IDs
less
MGD-MRK-10743
References
more
  • Summaries
    All50
    Developmental Gene Expression12
    Gene Ontology10
    Phenotypes7
  • Earliest
    J:2276 Murtha MT, et al., Detection of homeobox genes in development and evolution. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10711-5
  • Latest
    J:300359 Zhang H, et al., An IL-27-Driven Transcriptional Network Identifies Regulators of IL-10 Expression across T Helper Cell Subsets. Cell Rep. 2020 Nov 24;33(8):108433
TSS for Hlx:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr15647Chr1:184464829-184464891 (-)-170 bp
Tssr15646Chr1:184464813-184464824 (-)-129 bp
Tssr15645Chr1:184464728-184464742 (-)-45 bp
Tssr15644Chr1:184464693-184464722 (-)-18 bp
Tssr15643Chr1:184464641-184464688 (-)25 bp
Tssr15642Chr1:184464625-184464636 (-)59 bp
Tssr15641Chr1:184464356-184464384 (-)320 bp
Tssr15640Chr1:184464326-184464346 (-)354 bp
Tssr15639Chr1:184464304-184464315 (-)380 bp
Tssr15638Chr1:184464133-184464146 (-)550 bp
Tssr15637Chr1:184464061-184464079 (-)620 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support.		 last database update
03/18/2025
MGI 6.24		The Jackson Laboratory
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