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Grik1Gene Detail
Summary
  • Symbol
    Grik1
  • Name
    glutamate receptor, ionotropic, kainate 1
  • Synonyms
    A830007B11Rik, D16Ium24, D16Ium24e, GluK5, Glur-5, Glur5, Glurbeta1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95814
    NCBI Gene:14805
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:87692788-88087153 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 50.23 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    23977from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_95814
protein coding geneChr16:87692788-88087751 (-)
129S1/SvImJMGP_129S1SvImJ_G0022982
protein coding geneChr16:88647688-88841725 (-)
A/JMGP_AJ_G0022950
protein coding geneChr16:84557698-84743987 (-)
AKR/JMGP_AKRJ_G0022920
protein coding geneChr16:87131139-87309487 (-)
BALB/cJMGP_BALBcJ_G0022952
protein coding geneChr16:85086861-85270339 (-)
C3H/HeJMGP_C3HHeJ_G0022714
protein coding geneChr16:87695898-87853531 (-)
C57BL/6NJMGP_C57BL6NJ_G0023399
protein coding geneChr16:91516487-91704030 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0020903
protein coding geneChr16:82403607-82559065 (-)
CAST/EiJMGP_CASTEiJ_G0022236
protein coding geneChr16:88089648-88295753 (-)
CBA/JMGP_CBAJ_G0022683
protein coding geneChr16:95435069-95646628 (-)
DBA/2JMGP_DBA2J_G0022817
protein coding geneChr16:84489796-84670976 (-)
FVB/NJMGP_FVBNJ_G0022792
protein coding geneChr16:83582067-83771989 (-)
LP/JMGP_LPJ_G0022886
protein coding geneChr16:88330505-88523773 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0022811
protein coding geneChr16:99992615-100193948 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0023417
protein coding geneChr16:87608715-87800339 (-)
PWK/PhJMGP_PWKPhJ_G0021979
protein coding geneChr16:84595113-84806694 (-)
SPRET/EiJMGP_SPRETEiJ_G0021809
protein coding geneChr16:87150785-87340049 (-)
WSB/EiJMGP_WSBEiJ_G0022284
protein coding geneChr16:87839918-88033002 (-)



Homology
more
  • Human Ortholog
    GRIK1, glutamate ionotropic receptor kainate type subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIK1,glutamate ionotropic receptor kainate type subunit 1
  • Synonyms
    EAA3, EEA3, GLR5, GluK1, gluR-5, GLUR5
  • Links
    NCBI Gene ID:2897
    UniProt:P39086

  • Chr Location
    21q21.3; chr21:29536933-29940033(-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GRIK1 associations

Human DiseaseMouse Models
    
IDs
childhood absence epilepsy      

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypesfrom 3 allelesin 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    55 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display subtile abnormalities in the electrophysiology of neurons in the brain. Response to chemical pain stimuli is also reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000022935Ensembl Gene Model |MGI Sequence Detail394366C57BL/6J± kb
transcriptENSMUST00000227986Ensembl |MGI Sequence Detail2942Not Applicable 
polypeptideENSMUSP00000153786Ensembl |MGI Sequence Detail949Not Applicable 
For the selected sequence
Protein
Information
less
  • UniProt
    15 Sequences
  • Protein Ontology
    PR:000008240 glutamate receptor ionotropic, kainate 1
  • InterPro Domains
    IPR015683 Ionotropic glutamate receptor
    IPR001320 Ionotropic glutamate receptor, C-terminal
    IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
    IPR001508 Ionotropic glutamate receptor, metazoa
    IPR028082 Periplasmic binding protein-like I
    IPR001828 Receptor, ligand binding region
  • GlyGen
    Q60934 9 sites, 9 N-linked glycans (6 sites)
Molecular
Reagents
less
  • All nucleic35
    Genomic1
    cDNA27
    Primer pair5
    Other2

    Microarray probesets3
Other
Accession IDs
less
MGD-MRK-10144, MGD-MRK-10151, MGD-MRK-10252, MGD-MRK-33850, MGI:106163, MGI:2443714
References
more
  • Summaries
    All144
    Developmental Gene Expression20
    Gene Ontology27
    Phenotypes55
  • Earliest
    J:40449 Sommer B, et al., RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell. 1991 Oct 4;67(1):11-9
  • Latest
    J:361105 Tateossian H, et al., DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome. Elife. 2025;
TSS for Grik1:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr141953Chr16:88087087-88087114 (-)52 bp
Tssr141952Chr16:88087074-88087085 (-)73 bp
Tssr141951Chr16:88022320-88022334 (-)64,826 bp
Tssr141950Chr16:87964326-87964327 (-)122,826 bp
Tssr141949Chr16:87699163-87699168 (-)387,987 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support.		 last database update
03/18/2025
MGI 6.24		The Jackson Laboratory
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