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Fgfr2Gene Detail
Summary
  • Symbol
    Fgfr2
  • Name
    fibroblast growth factor receptor 2
  • Synonyms
    Bek, Fgfr-2, Fgfr2b, Fgfr-7, Fgfr7, KGFRTr, svs
  • Feature Type
    protein coding gene
  • IDs
    MGI:95523
    NCBI Gene:14183
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:129764181-129868538 bp, - strand
    From NCBI annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 73.19 cM
  • Mapping Data
    14 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2850from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_95523
protein coding geneChr7:129764181-132725079 (-)
129S1/SvImJMGP_129S1SvImJ_G0033090
protein coding geneChr7:134667329-134775531 (-)
A/JMGP_AJ_G0033072
protein coding geneChr7:130997243-131108181 (-)
AKR/JMGP_AKRJ_G0033004
protein coding geneChr7:134483684-134592301 (-)
BALB/cJMGP_BALBcJ_G0033073
protein coding geneChr7:130676817-130780908 (-)
C3H/HeJMGP_C3HHeJ_G0032787
protein coding geneChr7:134362330-134469420 (-)
C57BL/6NJMGP_C57BL6NJ_G0033583
protein coding geneChr7:139863465-139977551 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0030555
protein coding geneChr7:132175024-132279477 (-)
CAST/EiJMGP_CASTEiJ_G0032117
protein coding geneChr7:126168763-126277865 (-)
CBA/JMGP_CBAJ_G0032760
protein coding geneChr7:144645815-144759823 (-)
DBA/2JMGP_DBA2J_G0032912
protein coding geneChr7:129000333-129104550 (-)
FVB/NJMGP_FVBNJ_G0032865
protein coding geneChr7:128859552-128967858 (-)
LP/JMGP_LPJ_G0033006
protein coding geneChr7:136144069-136251933 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0032897
protein coding geneChr7:145629400-145736428 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0033602
protein coding geneChr7:133418350-133532579 (-)
PWK/PhJMGP_PWKPhJ_G0031823
protein coding geneChr7:122059626-122170384 (-)
SPRET/EiJMGP_SPRETEiJ_G0031669
protein coding geneChr7:120250019-120360485 (-)
WSB/EiJMGP_WSBEiJ_G0032228
protein coding geneChr7:134416681-134523175 (-)



Homology
more
  • Human Ortholog
    FGFR2, fibroblast growth factor receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FGFR2,fibroblast growth factor receptor 2
  • Synonyms
    BBDS, BEK, BFR-1, CD332, CEK3, CFD1, ECT1, JWS, KGFR, K-SAM, TK14, TK25
  • Links
    NCBI Gene ID:2263
    UniProt:P21802

  • Chr Location
    10q26.13; chr10:121478330-121598458(-)  GRCh38
Human Diseases
more
  • Diseases
    5 with Fgfr2 mouse models;19 with human FGFR2 associations

Human DiseaseMouse Models
    
IDs
acrocephalosyndactylia      

DOID:12960
DOID:0080004
ICD9CM:755.55
MESH:D000168
NCI:C34348
OMIM:101200
UMLS_CUI:C1510455

View 8 models
Mouse Models

Human Disease Modeled: acrocephalosyndactylia

Allelic CompositionGenetic BackgroundReferencePhenotypes
Fgfr2tm2Ewj/Fgfr2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6JJ:156940View
Fgfr2tm3.1Cxd/Fgfr2+
involves: 129S6/SvEvTac * FVB/NJ:283626View
Fgfr2tm2.3Dsn/Fgfr2+
involves: 129 * C57BL/6 * FVB/NJ:72517View
Fgfr2tm2Ewj/Fgfr2+
Tg(EIIa-cre)C5379Lmgd/0
B6.Cg-Fgfr2tm2Ewj Tg(EIIa-cre)C5379LmgdJ:158773View
Fgfr2tm3Cxd/Fgfr2+
Tg(Col2a1-cre)1Xya/0
involves: 129S6/SvEvTac * C57BL/6JJ:286452View
Fgfr2tm1Ewj/Fgfr2+
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * FVB/NJ:101174J:156940View
Fgfr2tm2Cxd/Fgfr2+
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S6/SvEvTac * C57BL/6J * FVB/NJ:228708View
Fgfr2tm2Cxd/Fgfr2+
Tg(EIIa-cre)C5379Lmgd/0
involves: 129S6/SvEvTac * FVB/NJ:101385View
IDs
Beare-Stevenson cutis gyrata syndrome      
View 1 model
Mouse Models

Human Disease Modeled: Beare-Stevenson cutis gyrata syndrome

Allelic CompositionGenetic BackgroundReferencePhenotypes
Fgfr2tm3Ewj/Fgfr2+
B6.129-Fgfr2tm3EwjJ:190491View
IDs
Crouzon syndrome      

DOID:2339
ICD10CM:Q75.1
MESH:D003394
NCI:C84653
OMIM:123500
UMLS_CUI:C0010273

View 4 models
Mouse Models

Human Disease Modeled: Crouzon syndrome

Allelic CompositionGenetic BackgroundReferencePhenotypes
Fgfr2m1Sgg/Fgfr2m1Sgg
involves: C3H/HeJ * C57BL/6JJ:160674View
Fgfr2tm1Schl/Fgfr2+
involves: 129S1/SvJ:118299View
Fgfr2m1Sgg/Fgfr2+
involves: C3H/HeJ * C57BL/6JJ:160674View
Fgfr2tm4Lni/Fgfr2+
Not SpecifiedJ:92433J:235329View
IDs
Pfeiffer syndrome      
View 1 model
Mouse Models

Human Disease Modeled: Pfeiffer syndrome

Allelic CompositionGenetic BackgroundReferencePhenotypes
Fgfr2tm2.3Dsn/Fgfr2+
involves: 129 * C57BL/6 * FVB/NJ:72517View
    
IDs
intestinal atresia      

DOID:10486
ICD10CM:Q41.1
MESH:D007409
NCI:C84790
UMLS_CUI:C0021828

View 1 model
Mouse Models

Human Disease Modeled: intestinal atresia

Allelic CompositionGenetic BackgroundReferencePhenotypes
Fgfr2tm1.1Dsn/Fgfr2tm1.1Dsn
involves: 129P2/OlaHsd * C57BL/6J:92361View
    
IDs
Antley-Bixler syndrome      
IDs
Antley-Bixler syndrome without disordered steroidogenesis      
IDs
bent bone dysplasia syndrome 1      
IDs
breast cancer      

DOID:1612
DOID:1648
DOID:4241
ICD10CM:C50
ICD9CM:174.8
MESH:D001943
NCI:C9335
OMIM:114480
UMLS_CUI:C0006142

IDs
colorectal adenocarcinoma      

DOID:0050861
NCI:C5105
UMLS_CUI:C1319315

IDs
craniosynostosis      
IDs
dysgerminoma      

DOID:4441
MESH:D004407
UMLS_CUI:C0013377

IDs
female breast carcinoma      

DOID:7843
NCI:C2918
UMLS_CUI:C0007104

IDs
hepatocellular carcinoma      
IDs
Jackson-Weiss syndrome      
IDs
lacrimoauriculodentodigital syndrome 1      
IDs
Saethre-Chotzen syndrome      
IDs
stomach cancer      

DOID:10534
DOID:10539
DOID:10542
DOID:10543
DOID:4713
ICD10CM:C16
ICD10CM:C16.2
ICD10CM:C16.5
ICD10CM:C16.6
ICD9CM:151
ICD9CM:151.4
ICD9CM:151.5
ICD9CM:151.6
ICD9CM:151.9
MESH:D013274
NCI:C3387
NCI:C9331
OMIM:613659
UMLS_CUI:C0024623
UMLS_CUI:C0038356
UMLS_CUI:C0153421
UMLS_CUI:C0153422
UMLS_CUI:C0153423

IDs
stomach carcinoma      
IDs
urinary bladder cancer      

DOID:11054
DOID:5428
ICD10CM:C67
ICD9CM:188
ICD9CM:188.9
KEGG:05219
MESH:D001749
NCI:C2901
NCI:C9334
OMIM:109800
UMLS_CUI:C0005684
UMLS_CUI:C0005695


  • Mutations/Alleles
    12 with disease annotations
  • References
    15 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    389 phenotypesfrom 28 allelesin 38 genetic backgrounds
    76 phenotypes from multigenic genotypes
    29 images
    340 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for null mutations die as embryos. Isoform IIIb deficient mutants die at birth with defects in multiple organs and tissues. Isoform IIIc deficient mutants have defects in osteoblast and chondrocyte lineages, producing dwarfism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic14183NCBI Gene Model |MGI Sequence Detail104358C57BL/6J± kb
transcriptNM_010207RefSeq |MGI Sequence Detail5223C57BL/6 
polypeptideP21803UniProt |EBI |MGI Sequence Detail821Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic1006
    Genomic4
    cDNA896
    Primer pair58
    Other48

    Microarray probesets5
Other
Accession IDs
less
MGD-MRK-14668, MGD-MRK-1537, MGD-MRK-9777, MGD-MRK-9780, MGD-MRK-9782, MGD-MRK-9785, MGI:2142159, MGI:2142264, MGI:98454
References
more
  • Summaries
    All818
    Developmental Gene Expression452
    Diseases15
    Gene Ontology56
    Phenotypes340
  • Earliest
    J:9441 Shukri NM, et al., Recessive mutation in a standard recombinant-inbred line of mice affects seminal vesicle shape. Genet Res. 1988 Aug;52(1):27-32
  • Latest
    J:374632 Liu X, et al., Interplay of ECM organization, ROCK signaling, and cell polarity drives mesothelium formation and lung growth. Nat Commun. 2025 Oct 30;16(1):9610
TSS for Fgfr2:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr75147Chr7:129867967-129867991 (-)559 bp
Tssr75146Chr7:129867946-129867955 (-)587 bp
Tssr75145Chr7:129865949-129865963 (-)2,582 bp
Tssr75144Chr7:129864546-129864558 (-)3,986 bp
Tssr75143Chr7:129846290-129846335 (-)22,225 bp
Tssr75142Chr7:129844002-129844006 (-)24,534 bp
Tssr75141Chr7:129818624-129818628 (-)49,912 bp
Tssr75140Chr7:129802912-129802921 (-)65,621 bp
Tssr75139Chr7:129802097-129802102 (-)66,438 bp
Tssr75138Chr7:129794047-129794052 (-)74,488 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
10/07/2025
MGI 6.24		The Jackson Laboratory
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