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CtsgGene Detail
Summary
  • Symbol
    Ctsg
  • Name
    cathepsin G
  • Feature Type
    protein coding gene
  • IDs
    MGI:88563
    NCBI Gene:13035
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:56337342-56340031 bp, - strand
    From NCBI annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_88563
protein coding geneChr14:56337338-56340031 (-)
129S1/SvImJMGP_129S1SvImJ_G0021384
protein coding geneChr14:50175285-50177978 (-)
A/JMGP_AJ_G0021343
protein coding geneChr14:49179634-49182327 (-)
AKR/JMGP_AKRJ_G0021319
protein coding geneChr14:50936350-50939043 (-)
BALB/cJMGP_BALBcJ_G0021346
protein coding geneChr14:49149837-49152530 (-)
C3H/HeJMGP_C3HHeJ_G0021127
protein coding geneChr14:50619798-50622491 (-)
C57BL/6NJMGP_C57BL6NJ_G0021786
protein coding geneChr14:52698088-52700781 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0019328
protein coding geneChr14:47393134-47395789 (-)
CAST/EiJMGP_CASTEiJ_G0020646
protein coding geneChr14:46903200-46905826 (-)
CBA/JMGP_CBAJ_G0021094
protein coding geneChr14:54241282-54243975 (-)
DBA/2JMGP_DBA2J_G0021214
protein coding geneChr14:48902457-48905118 (-)
FVB/NJMGP_FVBNJ_G0021197
protein coding geneChr14:48317944-48320636 (-)
LP/JMGP_LPJ_G0021289
protein coding geneChr14:51217915-51220608 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0021221
protein coding geneChr14:53602339-53605031 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0021812
protein coding geneChr14:50122910-50125603 (-)
PWK/PhJMGP_PWKPhJ_G0020390
protein coding geneChr14:45425859-45428552 (-)
SPRET/EiJMGP_SPRETEiJ_G0020220
protein coding geneChr14:46179501-46182188 (-)
WSB/EiJMGP_WSBEiJ_G0020699
protein coding geneChr14:50379956-50382648 (-)



Homology
more
  • Human Ortholog
    CTSG, cathepsin G
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CTSG,cathepsin G
  • Synonyms
    CATG, CG
  • Links
    NCBI Gene ID:1511
    UniProt:P08311

  • Chr Location
    14q12; chr14:24573518-24576250(-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypesfrom 2 allelesin 3 genetic backgrounds
    19 phenotypes from multigenic genotypes
    52 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased susceptibility to bacterial infection induced mortality but increased susceptibility to mortality induced by fungal infection. Mice either homozygous or heterozygous for a knock-in allele develop an abrupt onset, rapidly fatal acute leukemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic13035NCBI Gene Model |MGI Sequence Detail2690C57BL/6J± kb
transcriptNM_007800RefSeq |MGI Sequence Detail1015ZRU/MplStud 
polypeptideP28293UniProt |EBI |MGI Sequence Detail261Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic24
    Genomic7
    cDNA16
    Other1

    Microarray probesets2
Other
Accession IDs
less
MGD-MRK-2247
References
more
  • Summaries
    All90
    Developmental Gene Expression2
    Diseases2
    Gene Ontology13
    Phenotypes52
  • Earliest
    J:9920 Hohn PA, et al., Genomic organization and chromosomal localization of the human cathepsin G gene. J Biol Chem. 1989 Aug 15;264(23):13412-9
  • Latest
    J:371810 Kline SN, et al., Epicutaneous Staphylococcus aureus initiates cross-tissue IL-36R signaling for neutrophilic lung inflammation in a model of the atopic march. Cell Rep. 2025 Aug 26;44(8):116054
TSS for Ctsg:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr128913Chr14:56339915-56339929 (-)109 bp
Tssr128912Chr14:56338170-56338180 (-)1,856 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
10/07/2025
MGI 6.24		The Jackson Laboratory
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