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CpGene Detail

Summary

Symbol
Cp
Name
ceruloplasmin
Synonyms
D3Ertd555e

Feature Type
protein coding gene
IDs
MGI:88476
NCBI Gene:12870
Alliance
gene page
Transcription Start Sites
25 TSS

Location &
Maps

Sequence Map
Chr3:20011218-20063309 bp, + strand
From Ensembl annotation of GRCm39
View this region inJBrowse
Genome Browsers
Ensembl |UCSC |NCBI

Genetic Map
Chromosome 3, 6.10 cM, cytoband D
Mapping Data
8 experiments

Strain
Comparison

SNPs within 2kb
1761from dbSNP Build 142
Strain Annotations
18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_88476	protein coding gene	Chr3:20011097-20063914 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027097	protein coding gene	Chr3:17161773-17213417 (+)
A/J	MGP_AJ_G0027057	protein coding gene	Chr3:17082181-17136846 (+)
AKR/J	MGP_AKRJ_G0027026	protein coding gene	Chr3:17249899-17302819 (+)
BALB/cJ	MGP_BALBcJ_G0027069	protein coding gene	Chr3:16837418-16890203 (+)
C3H/HeJ	MGP_C3HHeJ_G0026810	protein coding gene	Chr3:17273879-17328338 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027514	protein coding gene	Chr3:18241816-18302448 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024876	protein coding gene	Chr3:15149996-15201795 (+)
CAST/EiJ	MGP_CASTEiJ_G0026265	protein coding gene	Chr3:17181670-17237920 (+)
CBA/J	MGP_CBAJ_G0026788	protein coding gene	Chr3:18646814-18704207 (+)
DBA/2J	MGP_DBA2J_G0026922	protein coding gene	Chr3:16702375-16756158 (+)
FVB/NJ	MGP_FVBNJ_G0026890	protein coding gene	Chr3:16358085-16412938 (+)
LP/J	MGP_LPJ_G0027034	protein coding gene	Chr3:17813964-17867144 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026911	protein coding gene	Chr3:20721753-20778709 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027574	protein coding gene	Chr3:17039649-17095498 (+)
PWK/PhJ	MGP_PWKPhJ_G0025998	protein coding gene	Chr3:16397306-16452306 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025807	protein coding gene	Chr3:16837239-16896461 (+)
WSB/EiJ	MGP_WSBEiJ_G0026338	protein coding gene	Chr3:17039453-17100319 (+)

Homology

Human Ortholog
CP, ceruloplasmin

Vertebrate Orthologs
3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog
CP,ceruloplasmin
Synonyms
AB073614, CP-2
Links
HGNC:2295
NCBI Gene ID:1356
UniProt:P00450
Chr Location
3q24-q25.1; chr3:149162410-149221829(-) GRCh38

MGI Vertebrate Homology
Cp stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP
vertebrate homology predictions:CP
Protein SuperFamily
Factors_V_VIII
Gene Tree
Cp

Human Diseases

Diseases
1 with Cp mouse models;3 with human CP associations

Human Disease

Mouse Models

aceruloplasminemia

IDs

aceruloplasminemia

DOID:0050711
OMIM:604290

View 3 models

Mouse Models

Human Disease Modeled: aceruloplasminemia

Allelic Composition	Genetic Background	Reference	Phenotypes
Cptm1Hrs/Cptm1Hrs	involves: 129X1/SvJ * Black Swiss	J:57730 J:71807	View
Cptm1Yos/Cptm1Yos	C.129P2-Cp^tm1Yos	J:142713	View
Cptm1Hrs/Cptm1Hrs Hephsla/Y	involves: 129X1/SvJ * C57BL/6	J:92620	View

epilepsy

IDs

epilepsy

DOID:1826
EFO:0000474
ICD10CM:G40
ICD9CM:345.9
MESH:D004827
NCI:C3020
UMLS_CUI:C0014544

hemosiderosis

IDs

hemosiderosis

DOID:12119
MESH:D006486
UMLS_CUI:C0019114

Mutations/Alleles
2 with disease annotations

References
6 with disease annotations

Mutations,
Alleles, and
Phenotypes

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Phenotype Summary
41 phenotypesfrom 6 allelesin 7 genetic backgrounds
22 phenotypes from multigenic genotypes
4 images
64 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles
14
Chemically induced (ENU)
1
Endonuclease-mediated
4
Radiation induced
1
Spontaneous
2
Targeted
6
Genomic Mutations
1 involving Cp
Incidental Mutations
Mutagenetix,APF,CvDC
Find Mice (IMSR)
78 strains or lines available
Comparison Matrix
Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit progressive accumulation of stored iron in the liver, spleen, cerebellum, and brainstem, mild iron deficiency anemia, and impaired motor coordination associated with loss of brainstem dopaminergic neurons.

Gene Ontology
(GO)
Classifications

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All GO Annotations
51
GO References
15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

Expression

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results
1031
Tissues
188
cDNA Data
386
Literature Summary
12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links
Allen Institute
GEO
Expression Atlas
Other Vertebrate Links
Xenbasecp
ZFINcp

Sequences &
Gene Models

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All Sequences
93
RefSeq
22
UniProt
11
CCDS
CCDS38400.1,CCDS38401.1,CCDS71227.1,CCDS89616.1

Ensembl
ENSMUSG00000003617 (Evidence)
NCBI Gene
12870

			Length	Strain/Species	Flank
genomic	ENSMUSG00000003617	Ensembl Gene Model \|MGI Sequence Detail	52092	C57BL/6J	± kb
transcript	ENSMUST00000108329	Ensembl \|MGI Sequence Detail	4564	Not Applicable
polypeptide	ENSMUSP00000103965	Ensembl \|MGI Sequence Detail	1086	Not Applicable

Protein
Information

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UniProt
11 Sequences
Protein Ontology
PR:000005794 ceruloplasmin
(term hierarchy)
EC
1.11.1.27,1.11.1.9,1.16.3.1,1.16.3.4
InterPro Domains
IPR048236 Ceruloplasmin-like, fifth cupredoxin domain
IPR024715 Coagulation factor 5/8-like
IPR008972 Cupredoxin
IPR045087 Multicopper oxidase
IPR002355 Multicopper oxidase, copper-binding site
IPR011706 Multicopper oxidase, C-terminal
IPR011707 Multicopper oxidase-like, N-terminal
IPR033138 Multicopper oxidases, conserved site
IPR001117 Multicopper oxidase, second cupredoxin domain
GlyGen
Q61147 7 sites, 6 N-linked glycans (2 sites), 1 O-linked glycan (1 site)

Molecular
Reagents

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All nucleic394
Genomic3
cDNA387
Primer pair4
Antibodies2

Microarray probesets10

Other
Accession IDs

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MGD-MRK-2100, MGI:1261828

References

Summaries
All118
Developmental Gene Expression12
Diseases6
Gene Ontology15
Phenotypes64
Earliest
J:7811 Baranov VS, et al., [Mapping of the ceruloplasmin gene on human and laboratory mouse chromosomes by direct in situ hybridization]. Genetika. 1985 Mar;21(3):409-19
Latest
J:377271 Kedari KG, et al., Astrocyte-specific deletion of ceruloplasmin exacerbates oxidative stress and demyelination in the spinal cord in a murine model of multiple sclerosis. Neurobiol Dis. 2025 Dec 25;:107249

TSS for Cp:

(View these features inJBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr28534	Chr3:20011089-20011094 (+)	-126 bp
Tssr28535	Chr3:20011150-20011157 (+)	-64 bp
Tssr28536	Chr3:20011201-20011237 (+)	1 bp
Tssr28537	Chr3:20011252-20011278 (+)	47 bp
Tssr28538	Chr3:20011283-20011295 (+)	71 bp
Tssr28539	Chr3:20011334-20011343 (+)	121 bp
Tssr28540	Chr3:20011379-20011388 (+)	166 bp
Tssr28541	Chr3:20011404-20011427 (+)	198 bp
Tssr28542	Chr3:20011505-20011520 (+)	295 bp
Tssr28543	Chr3:20020509-20020520 (+)	9,297 bp
Tssr28544	Chr3:20020527-20020547 (+)	9,319 bp
Tssr28545	Chr3:20025079-20025088 (+)	13,866 bp
Tssr28546	Chr3:20025176-20025193 (+)	13,967 bp
Tssr28547	Chr3:20026789-20026800 (+)	15,577 bp
Tssr28548	Chr3:20029130-20029143 (+)	17,919 bp
Tssr28549	Chr3:20034753-20034762 (+)	23,540 bp
Tssr839	Chr3:20039775-20039787 (+)	28,563 bp
Tssr28550	Chr3:20039796-20039807 (+)	28,584 bp
Tssr28551	Chr3:20043219-20043233 (+)	32,008 bp
Tssr28552	Chr3:20043298-20043313 (+)	32,088 bp
Tssr28553	Chr3:20043315-20043328 (+)	32,104 bp
Tssr28554	Chr3:20043340-20043355 (+)	32,130 bp
Tssr28555	Chr3:20046787-20046803 (+)	35,577 bp
Tssr28556	Chr3:20046939-20046957 (+)	35,730 bp
Tssr840	Chr3:20046960-20046981 (+)	35,753 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 01/28/2026 MGI 6.24

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