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AvpGene Detail
Summary
  • Symbol
    Avp
  • Name
    arginine vasopressin
  • Synonyms
    Vp, Vsp
  • Feature Type
    protein coding gene
  • IDs
    MGI:88121
    NCBI Gene:11998
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:130422540-130424474 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.24 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    150from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6Jno annotation
129S1/SvImJMGP_129S1SvImJ_G0026509
protein coding geneChr2:134046637-134048571 (-)
A/JMGP_AJ_G0026473
protein coding geneChr2:128620032-128621966 (-)
AKR/JMGP_AKRJ_G0026448
protein coding geneChr2:132329674-132331608 (-)
BALB/cJMGP_BALBcJ_G0026485
protein coding geneChr2:128975051-128976984 (-)
C3H/HeJMGP_C3HHeJ_G0026228
protein coding geneChr2:132760919-132762853 (-)
C57BL/6NJMGP_C57BL6NJ_G0026930
protein coding geneChr2:138187376-138189310 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0024307
protein coding geneChr2:123364046-123366006 (-)
CAST/EiJMGP_CASTEiJ_G0025689
protein coding geneChr2:133016668-133018601 (-)
CBA/JMGP_CBAJ_G0026208
protein coding geneChr2:143295937-143297871 (-)
DBA/2JMGP_DBA2J_G0026342
protein coding geneChr2:128006870-128008804 (-)
FVB/NJMGP_FVBNJ_G0026306
protein coding geneChr2:126634534-126636468 (-)
LP/JMGP_LPJ_G0026447
protein coding geneChr2:134291833-134293767 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0026326
protein coding geneChr2:147144975-147146909 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0026985
protein coding geneChr2:132283979-132285913 (-)
PWK/PhJMGP_PWKPhJ_G0025425
protein coding geneChr2:127563245-127565178 (-)
SPRET/EiJMGP_SPRETEiJ_G0025227
protein coding geneChr2:131407030-131408934 (-)
WSB/EiJMGP_WSBEiJ_G0025763
protein coding geneChr2:133206754-133208688 (-)



Homology
more
  • Human Ortholog
    AVP, arginine vasopressin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    AVP,arginine vasopressin
  • Synonyms
    ADH, ARVP, AVP-NPII, AVRP, VP
  • Links
    NCBI Gene ID:551
    neXtProt AC:NX_P01185
    UniProt:P01185

  • Chr Location
    20p13; chr20:3082556-3084724(-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Avp mouse models;2 with human AVP associations

Human DiseaseMouse Models
    
IDs
neurohypophyseal diabetes insipidus      
View 2 models
Mouse Models

Human Disease Modeled: neurohypophyseal diabetes insipidus

Allelic CompositionGenetic BackgroundReferencePhenotypes
Avptm1Hari/Avp+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6JJ:147993View
Avptm1Lja/Avp+
involves: 129S1/Sv * 129X1/SvJJ:148012View
    
IDs
diabetes insipidus      

DOID:9409
ICD10CM:E23.2
ICD9CM:253.5
MESH:D003919
NCI:C43263
UMLS_CUI:C0011848


  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypesfrom 6 allelesin 5 genetic backgrounds
    64 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a premature stop mutation display postnatal lethality. Heterozygous mice display polyuria, increased water intake, decreased urine osmolality, and hypothalamic abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000037727Ensembl Gene Model |MGI Sequence Detail1935C57BL/6J± kb
transcriptENSMUST00000046001Ensembl |MGI Sequence Detail577Not Applicable 
polypeptideENSMUSP00000035551Ensembl |MGI Sequence Detail168Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic38
    Genomic10
    cDNA19
    Primer pair3
    Other6

    Microarray probesets3
Other
Accession IDs
less
MGD-MRK-1485, MGD-MRK-15404, MGD-MRK-15416
References
more
  • Summaries
    All197
    Developmental Gene Expression65
    Diseases2
    Gene Ontology6
    Phenotypes64
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:359469 Borie AM, et al., Neuropeptide therapeutics to repress lateral septum neurons that disable sociability in an autism mouse model. Cell Rep Med. 2024 Nov 19;5(11):101781
TSS for Avp:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr26301Chr2:130424489-130424494 (-)-18 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
12/10/2024
MGI 6.24		The Jackson Laboratory
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