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Foxi3Gene Detail
Summary
  • Symbol
    Foxi3
  • Name
    forkhead box I3
  • Feature Type
    protein coding gene
  • IDs
    MGI:3511278
    NCBI Gene:232077
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:70933590-70938050 bp, + strand
    From NCBI annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.14 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    183from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_3511278
protein coding geneChr6:70933515-70938050 (+)
129S1/SvImJMGP_129S1SvImJ_G0030851
protein coding geneChr6:71399677-71404196 (+)
A/JMGP_AJ_G0030821
protein coding geneChr6:68664458-68668979 (+)
AKR/JMGP_AKRJ_G0030750
protein coding geneChr6:70643131-70647653 (+)
BALB/cJMGP_BALBcJ_G0030832
protein coding geneChr6:68695140-68699659 (+)
C3H/HeJMGP_C3HHeJ_G0030880
protein coding geneChr6:113614679-113619210 (-)
C57BL/6NJMGP_C57BL6NJ_G0031290
protein coding geneChr6:73282087-73286620 (+)
CAROLI/EiJMGP_CAROLIEiJ_G0028479
protein coding geneChr6:67851494-67855940 (+)
CAST/EiJMGP_CASTEiJ_G0029940
protein coding geneChr6:70478632-70483175 (+)
CBA/JMGP_CBAJ_G0030519
protein coding geneChr6:76178726-76183259 (+)
DBA/2JMGP_DBA2J_G0030671
protein coding geneChr6:68038971-68043488 (+)
FVB/NJMGP_FVBNJ_G0030624
protein coding geneChr6:67408320-67412843 (+)
LP/JMGP_LPJ_G0030750
protein coding geneChr6:71331902-71336427 (+)
NOD/ShiLtJMGP_NODShiLtJ_G0030659
protein coding geneChr6:79702752-79707274 (+)
NZO/HlLtJMGP_NZOHlLtJ_G0031316
protein coding geneChr6:70479711-70484230 (+)
PWK/PhJMGP_PWKPhJ_G0029656
protein coding geneChr6:66896520-66901177 (+)
SPRET/EiJMGP_SPRETEiJ_G0029484
protein coding geneChr6:69197903-69203951 (+)
WSB/EiJMGP_WSBEiJ_G0030022
protein coding geneChr6:70812395-70816916 (+)



Homology
more
  • Human Ortholog
    FOXI3, forkhead box I3
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FOXI3,forkhead box I3
  • Synonyms
    CFM2
  • Links
    NCBI Gene ID:344167
    neXtProt AC:NX_A8MTJ6
    UniProt:A8MTJ6

  • Chr Location
    2p11.2; chr2:88446787-88452693(-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Foxi3 mouse models

Human DiseaseMouse Models
    
IDs
Goldenhar syndrome      
View 1 model
Mouse Models

Human Disease Modeled: Goldenhar syndrome

Allelic CompositionGenetic BackgroundReferencePhenotypes
Foxi3em1Ybz/Foxi3em1Ybz
C57BL/6-Foxi3em1YbzJ:336768View

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    50 phenotypesfrom 5 allelesin 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice start dying after E9.5. Those born die neonatally, lack a mouth and whiskers, and show branchial arch-derived skeletal defects, including a reduced mandible, total absence of inner, middle and external ear structures, and increased cranial neural crest cell apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic232077NCBI Gene Model |MGI Sequence Detail4461C57BL/6J± kb
transcriptNM_001101464RefSeq |MGI Sequence Detail1206mixed 
polypeptideD3Z120UniProt |EBI |MGI Sequence Detail399Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic8
    Genomic1
    cDNA4
    Primer pair2
    Other1

    Microarray probesets1
References
more
  • Summaries
    All40
    Developmental Gene Expression16
    Diseases1
    Gene Ontology13
    Phenotypes13
  • Earliest
    J:93815 Ohyama T, et al., Expression of mouse Foxi class genes in early craniofacial development. Dev Dyn. 2004 Nov;231(3):640-6
  • Latest
    J:344153 Raymundo JR, et al., KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions and their impairment causes aplasia cutis. J Clin Invest. 2023 Dec 19;:e174138
TSS for Foxi3:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr56981Chr6:70933440-70933444 (+)-148 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
03/18/2025
MGI 6.24		The Jackson Laboratory
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