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Zmiz1Gene Detail
Summary
  • Symbol
    Zmiz1
  • Name
    zinc finger, MIZ-type containing 1
  • Synonyms
    Rai17, Zimp10
  • Feature Type
    protein coding gene
  • IDs
    MGI:3040693
    NCBI Gene:328365
  • Alliance
  • Transcription Start Sites
    41 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:25459609-25667167 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 14, 15.03 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    7106from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_3040693
protein coding geneChr14:25458299-25667167 (+)
129S1/SvImJMGP_129S1SvImJ_G0021065
protein coding geneChr14:18387201-18597766 (+)
A/JMGP_AJ_G0021014
protein coding geneChr14:17931790-18143268 (+)
AKR/JMGP_AKRJ_G0020991
protein coding geneChr14:18567916-18779163 (+)
BALB/cJMGP_BALBcJ_G0021017
protein coding geneChr14:18034110-18245159 (+)
C3H/HeJMGP_C3HHeJ_G0020801
protein coding geneChr14:18490242-18700216 (+)
C57BL/6NJMGP_C57BL6NJ_G0021450
protein coding geneChr14:18958774-19171810 (+)
CAROLI/EiJMGP_CAROLIEiJ_G0019018
protein coding geneChr14:18136518-18342578 (+)
CAST/EiJMGP_CASTEiJ_G0020325
protein coding geneChr14:18369522-18577153 (+)
CBA/JMGP_CBAJ_G0020767
protein coding geneChr14:19890289-20112101 (+)
DBA/2JMGP_DBA2J_G0020890
protein coding geneChr14:17736551-17944677 (+)
FVB/NJMGP_FVBNJ_G0020873
protein coding geneChr14:17610386-17824857 (+)
LP/JMGP_LPJ_G0020966
protein coding geneChr14:18664642-18876885 (+)
NOD/ShiLtJMGP_NODShiLtJ_G0020899
protein coding geneChr14:19589325-19804596 (+)
NZO/HlLtJMGP_NZOHlLtJ_G0021483
protein coding geneChr14:18364589-18577563 (+)
PWK/PhJMGP_PWKPhJ_G0020074
protein coding geneChr14:17354671-17566823 (+)
SPRET/EiJMGP_SPRETEiJ_G0019896
protein coding geneChr14:18201351-18406874 (+)
WSB/EiJMGP_WSBEiJ_G0020381
protein coding geneChr14:18356423-18568266 (+)



Homology
more
  • Human Ortholog
    ZMIZ1, zinc finger MIZ-type containing 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZMIZ1,zinc finger MIZ-type containing 1
  • Synonyms
    MIZ, NEDDFSA, RAI17, TRAFIP10, ZIMP10
  • Links
    NCBI Gene ID:57178
    neXtProt AC:NX_Q9ULJ6
    UniProt:Q9ULJ6

  • Chr Location
    10q22.3; chr10:79068966-79316519(+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypesfrom 2 allelesin 3 genetic backgrounds
    15 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality during organogenesis with failure of yolk sac vascular remodeling and abnormal embryonic vascular development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000007817Ensembl Gene Model |MGI Sequence Detail207559C57BL/6J± kb
transcriptENSMUST00000162645Ensembl |MGI Sequence Detail7482Not Applicable 
polypeptideENSMUSP00000124863Ensembl |MGI Sequence Detail1072Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic22
    cDNA19
    Primer pair2
    Other1

    Microarray probesets9
References
more
  • Summaries
    All54
    Developmental Gene Expression11
    Gene Ontology12
    Phenotypes15
  • Earliest
    J:86696 Zambrowicz BP, et al., Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14109-14
  • Latest
    J:356248 K C R, et al., Zmiz1 is a novel regulator of brain development associated with autism and intellectual disability. Front Psychiatry. 2024;15:1375492
TSS for Zmiz1:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr124600Chr14:25459303-25459314 (+)-300 bp
Tssr124601Chr14:25459630-25459649 (+)31 bp
Tssr124602Chr14:25459656-25459685 (+)62 bp
Tssr124603Chr14:25459691-25459721 (+)97 bp
Tssr124604Chr14:25459745-25459756 (+)142 bp
Tssr124606Chr14:25462925-25462933 (+)3,320 bp
Tssr124607Chr14:25466031-25466045 (+)6,429 bp
Tssr124608Chr14:25467155-25467170 (+)7,554 bp
Tssr124609Chr14:25467223-25467243 (+)7,624 bp
Tssr124610Chr14:25481591-25481648 (+)22,011 bp
Tssr124611Chr14:25481682-25481699 (+)22,082 bp
Tssr124612Chr14:25517928-25517948 (+)58,329 bp
Tssr124613Chr14:25530235-25530246 (+)70,632 bp
Tssr124614Chr14:25530296-25530309 (+)70,694 bp
Tssr124615Chr14:25530316-25530340 (+)70,719 bp
Tssr124616Chr14:25564693-25564720 (+)105,098 bp
Tssr124617Chr14:25576562-25576576 (+)116,960 bp
Tssr124618Chr14:25582016-25582042 (+)122,420 bp
Tssr124621Chr14:25598033-25598036 (+)138,426 bp
Tssr124622Chr14:25607735-25607773 (+)148,145 bp
Tssr124623Chr14:25607775-25607789 (+)148,173 bp
Tssr124624Chr14:25607831-25607865 (+)148,239 bp
Tssr124625Chr14:25608018-25608029 (+)148,415 bp
Tssr124626Chr14:25608042-25608080 (+)148,452 bp
Tssr124627Chr14:25608179-25608218 (+)148,590 bp
Tssr124628Chr14:25608221-25608234 (+)148,619 bp
Tssr124629Chr14:25608257-25608270 (+)148,655 bp
Tssr124630Chr14:25608314-25608357 (+)148,727 bp
Tssr124631Chr14:25608365-25608377 (+)148,762 bp
Tssr124632Chr14:25636358-25636385 (+)176,763 bp
Tssr124633Chr14:25642935-25642977 (+)183,347 bp
Tssr124634Chr14:25645139-25645177 (+)185,549 bp
Tssr124635Chr14:25650144-25650187 (+)190,557 bp
Tssr124636Chr14:25650935-25650944 (+)191,331 bp
Tssr124637Chr14:25657339-25657357 (+)197,739 bp
Tssr124638Chr14:25661829-25661859 (+)202,235 bp
Tssr124639Chr14:25663653-25663669 (+)204,052 bp
Tssr124640Chr14:25664319-25664336 (+)204,719 bp
Tssr124641Chr14:25664798-25664823 (+)205,202 bp
Tssr124642Chr14:25666356-25666374 (+)206,756 bp
Tssr124643Chr14:25666613-25666634 (+)207,015 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support.		 last database update
03/18/2025
MGI 6.24		The Jackson Laboratory
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