Movatterモバイル変換

[0]ホーム
URL:

  About  Help  FAQ
Kcnk13Gene Detail
Summary
  • Symbol
    Kcnk13
  • Name
    potassium channel, subfamily K, member 13
  • Synonyms
    F730021E22Rik, LOC380778, LOC381712, THIK-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:2384976
    NCBI Gene:217826
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:99930758-100028941 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 50.43 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2994from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_2384976
protein coding geneChr12:99928132-100028941 (+)
129S1/SvImJMGP_129S1SvImJ_G0020014
protein coding geneChr12:101417616-101516211 (+)
A/JMGP_AJ_G0019969
protein coding geneChr12:97611042-97708926 (+)
AKR/JMGP_AKRJ_G0019945
protein coding geneChr12:100242906-100342491 (+)
BALB/cJMGP_BALBcJ_G0019955
protein coding geneChr12:97950171-98050454 (+)
C3H/HeJMGP_C3HHeJ_G0019757
protein coding geneChr12:100783766-100885261 (+)
C57BL/6NJMGP_C57BL6NJ_G0020404
protein coding geneChr12:104536748-104640989 (+)
CAROLI/EiJMGP_CAROLIEiJ_G0018018
protein coding geneChr12:94576303-94681037 (+)
CAST/EiJMGP_CASTEiJ_G0019303
protein coding geneChr12:95891543-95994640 (+)
CBA/JMGP_CBAJ_G0019729
protein coding geneChr12:108421859-108522340 (+)
DBA/2JMGP_DBA2J_G0019840
protein coding geneChr12:97042591-97140736 (+)
FVB/NJMGP_FVBNJ_G0019829
protein coding geneChr12:95756599-95858914 (+)
LP/JMGP_LPJ_G0019916
protein coding geneChr12:101245997-101350445 (+)
NOD/ShiLtJMGP_NODShiLtJ_G0019871
protein coding geneChr12:112030724-112133504 (+)
NZO/HlLtJMGP_NZOHlLtJ_G0020433
protein coding geneChr12:99808764-99910422 (+)
PWK/PhJMGP_PWKPhJ_G0019067
protein coding geneChr12:91669892-91788742 (+)
SPRET/EiJMGP_SPRETEiJ_G0018863
protein coding geneChr12:93987262-94096828 (+)
WSB/EiJMGP_WSBEiJ_G0019357
protein coding geneChr12:100665224-100765739 (+)



Homology
more
  • Human Ortholog
    KCNK13, potassium two pore domain channel subfamily K member 13
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KCNK13,potassium two pore domain channel subfamily K member 13
  • Synonyms
    K2p13.1, THIK-1, THIK1
  • Links
    NCBI Gene ID:56659
    UniProt:Q9HB14

  • Chr Location
    14q32.11; chr14:90061994-90185853(+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypesfrom 1 allelein 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
  • Chemically induced (other)
  • Endonuclease-mediated
  • Targeted
  • Genomic Mutations
    1 involving Kcnk13
  • Incidental Mutations
  • Find Mice (IMSR)
Homozygous knockout reduces the surveillance activity of microglial cells in the brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000045404Ensembl Gene Model |MGI Sequence Detail98184C57BL/6J± kb
transcriptENSMUST00000049788Ensembl |MGI Sequence Detail3078Not Applicable 
polypeptideENSMUSP00000051846Ensembl |MGI Sequence Detail405Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic9
    cDNA8
    Primer pair1

    Microarray probesets3
Other
Accession IDs
less
MGI:2145065, MGI:2686416, MGI:2686531
References
more
  • Summaries
    All46
    Developmental Gene Expression3
    Gene Ontology11
    Phenotypes16
  • Earliest
    J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
  • Latest
    J:345713 Rifat A, et al., Differential contribution of THIK-1 K(+) channels and P2X7 receptors to ATP-mediated neuroinflammation by human microglia. J Neuroinflammation. 2024 Feb 26;21(1):58
TSS for Kcnk13:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr114673Chr12:99930772-99930783 (+)20 bp
Tssr114674Chr12:99930785-99930798 (+)34 bp
Tssr114675Chr12:99930929-99930956 (+)185 bp
Tssr114676Chr12:99931438-99931539 (+)731 bp
Tssr114677Chr12:99932012-99932047 (+)1,272 bp
Tssr114678Chr12:99932051-99932076 (+)1,306 bp
Tssr114679Chr12:99932186-99932205 (+)1,438 bp
Tssr114680Chr12:99937924-99937945 (+)7,177 bp
Tssr114681Chr12:99946174-99946186 (+)15,422 bp
Tssr114682Chr12:99965414-99965420 (+)34,659 bp
Tssr114683Chr12:99969945-99969962 (+)39,196 bp
Tssr114684Chr12:99973331-99973358 (+)42,587 bp
Tssr114685Chr12:99977014-99977028 (+)46,263 bp
Tssr114686Chr12:100010867-100010874 (+)80,113 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
01/20/2026
MGI 6.24		The Jackson Laboratory
This site uses cookies. Some cookies are essential for site operations and others help us analyze use and utility of our web site. Please refer to ourprivacy policy for more information.
CloseSave preferences
[8]ページ先頭
©2009-2026 Movatter.jp