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Hmgn3Gene Detail
Summary
  • Symbol
    Hmgn3
  • Name
    high mobility group nucleosomal binding domain 3
  • Synonyms
    1110002A15Rik, 6330514M13Rik, HMGN3a, HMGN3b, TRIP7
  • Feature Type
    protein coding gene
  • IDs
    MGI:2138069
    NCBI Gene:94353
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:82992001-83028738 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 45.29 cM, cytoband E3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1161from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_2138069
protein coding geneChr9:82991995-83029411 (-)
129S1/SvImJMGP_129S1SvImJ_G0035085
protein coding geneChr9:83775366-83812894 (-)
A/JMGP_AJ_G0035066
protein coding geneChr9:80864809-80901631 (-)
AKR/JMGP_AKRJ_G0034994
protein coding geneChr9:82763374-82800075 (-)
BALB/cJMGP_BALBcJ_G0035054
protein coding geneChr9:80512526-80550223 (-)
C3H/HeJMGP_C3HHeJ_G0034766
protein coding geneChr9:83297808-83334927 (-)
C57BL/6NJMGP_C57BL6NJ_G0035577
protein coding geneChr9:86078296-86118805 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0032485
protein coding geneChr9:79819606-79855027 (-)
CAST/EiJMGP_CASTEiJ_G0034084
protein coding geneChr9:83689483-83726100 (-)
CBA/JMGP_CBAJ_G0034739
protein coding geneChr9:89115588-89167502 (-)
DBA/2JMGP_DBA2J_G0034897
protein coding geneChr9:80449527-80490648 (-)
FVB/NJMGP_FVBNJ_G0034840
protein coding geneChr9:79607782-79644329 (-)
LP/JMGP_LPJ_G0034978
protein coding geneChr9:83972770-84010524 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0034882
protein coding geneChr9:90543686-90580808 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0035598
protein coding geneChr9:82938059-82975297 (-)
PWK/PhJMGP_PWKPhJ_G0033788
protein coding geneChr9:80620570-80657865 (-)
SPRET/EiJMGP_SPRETEiJ_G0033624
protein coding geneChr9:83112018-83147761 (-)
WSB/EiJMGP_WSBEiJ_G0034201
protein coding geneChr9:82916923-82957306 (-)



Homology
more
  • Human Ortholog
    HMGN3, high mobility group nucleosomal binding domain 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HMGN3,high mobility group nucleosomal binding domain 3
  • Synonyms
    PNAS-24, PNAS-25, TRIP7
  • Links
    NCBI Gene ID:9324
    UniProt:Q15651

  • Chr Location
    6q14.1; chr6:79201245-79234689(-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypesfrom 1 allelein 2 genetic backgrounds
    9 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired glucose tolerance with decreased insulin serum levels and increased glucose serum levels during feeding.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000066456Ensembl Gene Model |MGI Sequence Detail36738C57BL/6J± kb
transcriptENSMUST00000187193Ensembl |MGI Sequence Detail855Not Applicable 
polypeptideENSMUSP00000140980Ensembl |MGI Sequence Detail128Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic25
    cDNA24
    Primer pair1

    Microarray probesets3
Other
Accession IDs
less
MGI:1914636, MGI:1923404, MGI:2143355
References
more
  • Summaries
    All48
    Developmental Gene Expression10
    Gene Ontology11
    Phenotypes9
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
TSS for Hmgn3:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr90745Chr9:83028654-83028667 (-)77 bp
Tssr90744Chr9:83028581-83028641 (-)127 bp
Tssr90743Chr9:83028554-83028559 (-)181 bp
Tssr90742Chr9:83023232-83023238 (-)5,503 bp
Tssr90741Chr9:82994648-82994671 (-)34,078 bp
Tssr90740Chr9:82994625-82994647 (-)34,102 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
09/30/2025
MGI 6.24		The Jackson Laboratory
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