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PrlhrGene Detail
Summary
  • Symbol
    Prlhr
  • Name
    prolactin releasing hormone receptor
  • Synonyms
    Gpr10, GR3, LOC226278, PrRPR
  • Feature Type
    protein coding gene
  • IDs
    MGI:2135956
    NCBI Gene:226278
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr19:60455170-60456742 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 56.52 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    82from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_2135956
protein coding geneChr19:60454079-60457907 (-)
129S1/SvImJMGP_129S1SvImJ_G0025292
protein coding geneChr19:61039046-61040611 (-)
A/JMGP_AJ_G0025268
protein coding geneChr19:58061503-58063068 (-)
AKR/JMGP_AKRJ_G0025237
protein coding geneChr19:59875726-59877291 (-)
BALB/cJMGP_BALBcJ_G0025263
protein coding geneChr19:58135412-58136977 (-)
C3H/HeJMGP_C3HHeJ_G0025023
protein coding geneChr19:60129600-60131165 (-)
C57BL/6NJMGP_C57BL6NJ_G0025706
protein coding geneChr19:62506644-62508215 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0023118
protein coding geneChr19:56899387-56901026 (-)
CAST/EiJMGP_CASTEiJ_G0024488
protein coding geneChr19:60217249-60218814 (-)
CBA/JMGP_CBAJ_G0025003
protein coding geneChr19:65550437-65552002 (-)
DBA/2JMGP_DBA2J_G0025135
protein coding geneChr19:57813595-57815160 (-)
FVB/NJMGP_FVBNJ_G0025096
protein coding geneChr19:57520942-57522507 (-)
LP/JMGP_LPJ_G0025221
protein coding geneChr19:60877858-60879423 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0025129
protein coding geneChr19:64732485-64734050 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0025764
protein coding geneChr19:60121286-60122851 (-)
PWK/PhJMGP_PWKPhJ_G0024236
protein coding geneChr19:57802964-57804529 (-)
SPRET/EiJMGP_SPRETEiJ_G0024039
protein coding geneChr19:58768474-58770043 (-)
WSB/EiJMGP_WSBEiJ_G0024558
protein coding geneChr19:60223890-60225455 (-)



Homology
more
  • Human Ortholog
    PRLHR, prolactin releasing hormone receptor
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRLHR,prolactin releasing hormone receptor
  • Synonyms
    GPR10, GR3, PrRPR
  • Links
    NCBI Gene ID:2834
    UniProt:P49683

  • Chr Location
    10q26.11; chr10:118589997-118595648(-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PRLHR associations

Human DiseaseMouse Models
    
IDs
hypertension      

DOID:10763
EFO:0000537
ICD10CM:I10
ICD9CM:401-405.99
ICD9CM:997.91
MESH:D006973
NCI:C3117
UMLS_CUI:C0020538


Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypesfrom 3 allelesin 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene ate more than normal and became obese as they aged.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000045052Ensembl Gene Model |MGI Sequence Detail1573C57BL/6J± kb
transcriptENSMUST00000051277Ensembl |MGI Sequence Detail1573Not Applicable 
polypeptideENSMUSP00000063114Ensembl |MGI Sequence Detail370Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic5
    cDNA5

    Microarray probesets1
Other
Accession IDs
less
MGI:2685185
References
more
  • Summaries
    All36
    Gene Ontology11
    Phenotypes10
  • Earliest
    J:90533 Gu W, et al., The prolactin-releasing peptide receptor (GPR10) regulates body weight homeostasis in mice. J Mol Neurosci. 2004;22(1-2):93-103
  • Latest
    J:370065 Wang Y, et al., Roles for Prlhr/GPR10 and Npffr2/GPR74 in feeding responses to PrRP. Mol Metab. 2025 Feb;92:102093
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
01/20/2026
MGI 6.24		The Jackson Laboratory
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