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Arhgap35Gene Detail
Summary
  • Symbol
    Arhgap35
  • Name
    Rho GTPase activating protein 35
  • Synonyms
    6430596G11Rik, Grlf1, p190A, p190RhoGAP, P190 RhoGAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929494
    NCBI Gene:232906
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:16228398-16349313 bp, - strand
    From NCBI annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.15 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4466from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_1929494
protein coding geneChr7:16227644-16349313 (-)
129S1/SvImJMGP_129S1SvImJ_G0031712
protein coding geneChr7:14208277-14337287 (-)
A/JMGP_AJ_G0031684
protein coding geneChr7:13966575-14088140 (-)
AKR/JMGP_AKRJ_G0031609
protein coding geneChr7:14287510-14411562 (-)
BALB/cJMGP_BALBcJ_G0031691
protein coding geneChr7:14077184-14200190 (-)
C3H/HeJMGP_C3HHeJ_G0031413
protein coding geneChr7:14477422-14600198 (-)
C57BL/6NJMGP_C57BL6NJ_G0032157
protein coding geneChr7:14954782-15092777 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0029236
protein coding geneChr7:15517244-15637927 (-)
CAST/EiJMGP_CASTEiJ_G0030764
protein coding geneChr7:11237906-11358451 (-)
CBA/JMGP_CBAJ_G0031372
protein coding geneChr7:15428407-15557184 (-)
DBA/2JMGP_DBA2J_G0031528
protein coding geneChr7:13855683-13978453 (-)
FVB/NJMGP_FVBNJ_G0031484
protein coding geneChr7:13752952-13882863 (-)
LP/JMGP_LPJ_G0031613
protein coding geneChr7:14457148-14585179 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0031519
protein coding geneChr7:15375264-15502727 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0032186
protein coding geneChr7:14066186-14191009 (-)
PWK/PhJMGP_PWKPhJ_G0030488
protein coding geneChr7:11377751-11503663 (-)
SPRET/EiJMGP_SPRETEiJ_G0030315
protein coding geneChr7:8980975-9115471 (-)
WSB/EiJMGP_WSBEiJ_G0030861
protein coding geneChr7:14127114-14249921 (-)



Homology
more
  • Human Ortholog
    ARHGAP35, Rho GTPase activating protein 35
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARHGAP35,Rho GTPase activating protein 35
  • Synonyms
    GRF-1, GRLF1, P190-A, P190A, p190ARhoGAP, p190RhoGAP
  • Links
    NCBI Gene ID:2909
    UniProt:Q9NRY4

  • Chr Location
    19q13.32; chr19:46860997-47005077(+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    45 phenotypesfrom 3 allelesin 5 genetic backgrounds
    6 images
    19 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene usually die within 2 days of birth and never survive beyond 3 weeks. Observed phenotypes include defects in eye morphogenesis, forebrain development, neural tube closure, axon guidance and fasciculation, and renal abnormalities, including hypoplastic and glomerulocystic kidneys, associated with a ciliogenesis defect.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic232906NCBI Gene Model |MGI Sequence Detail120916C57BL/6J± kb
transcriptNM_172739RefSeq |MGI Sequence Detail8393C57BL/6 
polypeptideQ91YM2UniProt |EBI |MGI Sequence Detail1499Not Applicable 
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008262 Rho GTPase-activating protein 35
  • InterPro Domains
    IPR002713 FF domain
    IPR036517 FF domain superfamily
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR051978 Rho GTPase-activating domain-containing protein
    IPR000198 Rho GTPase-activating protein domain
    IPR032835 Rho GTPase-activating protein, FF domain
    IPR045786 Rho GTPase-activating protein, pG1 and pG2 domain
    IPR039007 Rho GTPase-activating protein, pG1 domain
    IPR039006 Rho GTPase-activating protein, pG2 domain
    IPR008936 Rho GTPase activation protein
    IPR001806 Small GTPase
  • GlyGen
    Q91YM2 5 sites, 2 N-linked glycans (2 sites), 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic15
    cDNA14
    Primer pair1

    Microarray probesets3
Other
Accession IDs
less
MGI:2142039
References
more
  • Summaries
    All56
    Developmental Gene Expression12
    Gene Ontology8
    Phenotypes19
  • Earliest
    J:65296 Brouns MR, et al., The adhesion signaling molecule p190 RhoGAP is required for morphogenetic processes in neural development. Development. 2000 Nov;127(22):4891-903
  • Latest
    J:346646 Sharma R, et al., The CPLANE protein Fuzzy regulates ciliogenesis by suppressing actin polymerization at the base of the primary cilium via p190A RhoGAP. Development. 2024 Mar 15;151(6):dev202322
TSS for Arhgap35:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr70763Chr7:16349191-16349201 (-)117 bp
Tssr70762Chr7:16348998-16349063 (-)282 bp
Tssr70761Chr7:16348979-16348992 (-)327 bp
Tssr70760Chr7:16348883-16348946 (-)398 bp
Tssr70759Chr7:16348806-16348816 (-)502 bp
Tssr70758Chr7:16348774-16348785 (-)533 bp
Tssr70757Chr7:16348717-16348730 (-)589 bp
Tssr70756Chr7:16348703-16348713 (-)605 bp
Tssr70755Chr7:16348595-16348636 (-)697 bp
Tssr70754Chr7:16348538-16348548 (-)770 bp
Tssr70753Chr7:16348473-16348531 (-)811 bp
Tssr70752Chr7:16338425-16338431 (-)10,885 bp
Tssr70751Chr7:16234252-16234255 (-)115,059 bp
Tssr70750Chr7:16231728-16231745 (-)117,576 bp
Tssr70749Chr7:16228652-16228656 (-)120,659 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
03/25/2025
MGI 6.24		The Jackson Laboratory
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