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Rassf5Gene Detail
Summary
  • Symbol
    Rassf5
  • Name
    Ras association (RalGDS/AF-6) domain family member 5
  • Synonyms
    1300019G20Rik, Nore1A, Nore1B, Rapl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1926375
    NCBI Gene:54354
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:131104147-131172915 bp, - strand
    From NCBI annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 56.91 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2835from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_1926375
protein coding geneChr1:131104147-131172995 (-)
129S1/SvImJMGP_129S1SvImJ_G0016451
protein coding geneChr1:134597817-134668592 (-)
A/JMGP_AJ_G0016434
protein coding geneChr1:129625863-129694370 (-)
AKR/JMGP_AKRJ_G0016399
protein coding geneChr1:133436227-133505958 (-)
BALB/cJMGP_BALBcJ_G0016394
protein coding geneChr1:129952542-130021767 (-)
C3H/HeJMGP_C3HHeJ_G0016220
protein coding geneChr1:133573101-133642613 (-)
C57BL/6NJMGP_C57BL6NJ_G0016855
protein coding geneChr1:139598583-139675600 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0014569
protein coding geneChr1:122761499-122828542 (-)
CAST/EiJMGP_CASTEiJ_G0015800
protein coding geneChr1:132574683-132643295 (-)
CBA/JMGP_CBAJ_G0016192
protein coding geneChr1:144410110-144480556 (-)
DBA/2JMGP_DBA2J_G0016299
protein coding geneChr1:128590812-128659679 (-)
FVB/NJMGP_FVBNJ_G0016298
protein coding geneChr1:127217021-127287713 (-)
LP/JMGP_LPJ_G0016370
protein coding geneChr1:135913496-135986333 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0016323
protein coding geneChr1:150174067-150245034 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0016891
protein coding geneChr1:133202541-133272391 (-)
PWK/PhJMGP_PWKPhJ_G0015586
protein coding geneChr1:127546668-127615957 (-)
SPRET/EiJMGP_SPRETEiJ_G0015373
protein coding geneChr1:132131507-132199903 (-)
WSB/EiJMGP_WSBEiJ_G0015862
protein coding geneChr1:133180518-133253274 (-)



Homology
more
  • Human Ortholog
    RASSF5, Ras association domain family member 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RASSF5,Ras association domain family member 5
  • Synonyms
    Maxp1, NORE1, NORE1A, NORE1B, RAPL, RASSF3
  • Links
    NCBI Gene ID:83593
    UniProt:Q8WWW0

  • Chr Location
    1q32.1; chr1:206507531-206589448(+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rassf5 mouse models

Human DiseaseMouse Models
    
IDs
View 1 model
Mouse Models

Human Disease Modeled: systemic lupus erythematosus

Allelic CompositionGenetic BackgroundReferencePhenotypes
Rassf5tm1Kina/Rassf5tm1Kina
B6.Cg-Rassf5tm1KinaJ:168749View

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypesfrom 2 allelesin 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    17 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a null allele have defects in lymphocyte homing to lymphoid tissues, B cell maturation and dendritic cell function, and display lymphocyte hyperproliferation leading to lupus glomerulonephritis and lymphomas. Homozygotes for another null allele are resistant to TNF-induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic54354NCBI Gene Model |MGI Sequence Detail68769C57BL/6J± kb
transcriptNM_018750RefSeq |MGI Sequence Detail3410ZRU/MplStud 
polypeptideQ5EBH1UniProt |EBI |MGI Sequence Detail413Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic37
    cDNA35
    Primer pair2

    Microarray probesets4
Other
Accession IDs
less
MGI:1921412, MGI:2138497
References
more
  • Summaries
    All56
    Developmental Gene Expression3
    Diseases1
    Gene Ontology6
    Phenotypes17
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:313924 Sandoval M, et al., Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium. Elife. 2021 Jan 4;10:e54618
TSS for Rassf5:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr13567Chr1:131172904-131172922 (-)2 bp
Tssr13566Chr1:131161397-131161416 (-)11,508 bp
Tssr13565Chr1:131127941-131127952 (-)44,968 bp
Tssr13564Chr1:131127918-131127925 (-)44,993 bp
Tssr13563Chr1:131127903-131127914 (-)45,006 bp
Tssr13562Chr1:131127826-131127882 (-)45,061 bp
Tssr13561Chr1:131127724-131127729 (-)45,188 bp
Tssr13560Chr1:131127696-131127712 (-)45,211 bp
Tssr13559Chr1:131127669-131127689 (-)45,236 bp
Tssr13558Chr1:131127656-131127665 (-)45,254 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
03/25/2025
MGI 6.24		The Jackson Laboratory
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