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Scn3bGene Detail
Summary
  • Symbol
    Scn3b
  • Name
    sodium channel, voltage-gated, type III, beta
  • Synonyms
    1110001K16Rik, 4833414B02Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1918882
    NCBI Gene:235281
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:40180513-40202914 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 21.42 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    778from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_1918882
protein coding geneChr9:40180512-40202914 (+)
129S1/SvImJMGP_129S1SvImJ_G0034666
protein coding geneChr9:38474520-38494563 (+)
A/JMGP_AJ_G0034646
protein coding geneChr9:37457311-37479466 (+)
AKR/JMGP_AKRJ_G0034572
protein coding geneChr9:38183442-38208419 (+)
BALB/cJMGP_BALBcJ_G0034637
protein coding geneChr9:37235987-37259273 (+)
C3H/HeJMGP_C3HHeJ_G0034348
protein coding geneChr9:38701255-38723338 (+)
C57BL/6NJMGP_C57BL6NJ_G0035160
protein coding geneChr9:39708756-39733496 (+)
CAROLI/EiJMGP_CAROLIEiJ_G0032073
protein coding geneChr9:37129258-37151317 (+)
CAST/EiJMGP_CASTEiJ_G0033671
protein coding geneChr9:38438399-38461578 (+)
CBA/JMGP_CBAJ_G0034321
protein coding geneChr9:41073062-41094665 (+)
DBA/2JMGP_DBA2J_G0034480
protein coding geneChr9:37427145-37451594 (+)
FVB/NJMGP_FVBNJ_G0034420
protein coding geneChr9:36655331-36677042 (+)
LP/JMGP_LPJ_G0034561
protein coding geneChr9:38751466-38775732 (+)
NOD/ShiLtJMGP_NODShiLtJ_G0034464
protein coding geneChr9:43122725-43143609 (+)
NZO/HlLtJMGP_NZOHlLtJ_G0035179
protein coding geneChr9:38110622-38138772 (+)
PWK/PhJMGP_PWKPhJ_G0033375
protein coding geneChr9:37239294-37261186 (+)
SPRET/EiJMGP_SPRETEiJ_G0033212
protein coding geneChr9:38347664-38369063 (+)
WSB/EiJMGP_WSBEiJ_G0033783
protein coding geneChr9:38123273-38146464 (+)



Homology
more
  • Human Ortholog
    SCN3B, sodium voltage-gated channel beta subunit 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SCN3B,sodium voltage-gated channel beta subunit 3
  • Synonyms
    ATFB16, BRGDA7, HSA243396, SCNB3
  • Links
    NCBI Gene ID:55800
    UniProt:Q9NY72

  • Chr Location
    11q24.1; chr11:123629187-123655244(-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Scn3b mouse models;1 with human SCN3B associations

Human DiseaseMouse Models
    
IDs
Brugada syndrome 7      
View 1 model
Mouse Models

Human Disease Modeled: Brugada syndrome 7

Allelic CompositionGenetic BackgroundReferencePhenotypes
Scn3btm1Clhh/Scn3btm1Clhh
129S/SvEv-Scn3btm1ClhhJ:177262View

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypesfrom 2 allelesin 2 genetic backgrounds
    8 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a ventricular arrhythmogenic phenotype with abnormal heart electrocardiography waveform features and sodium channel function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000049281Ensembl Gene Model |MGI Sequence Detail22402C57BL/6J± kb
transcriptENSMUST00000049941Ensembl |MGI Sequence Detail4150Not Applicable 
polypeptideENSMUSP00000051627Ensembl |MGI Sequence Detail215Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic67
    cDNA65
    Primer pair2

    Microarray probesets3
Other
Accession IDs
less
MGI:1915810
References
more
  • Summaries
    All53
    Developmental Gene Expression15
    Diseases1
    Gene Ontology12
    Phenotypes8
  • Earliest
    J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
TSS for Scn3b:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr84432Chr9:40180498-40180561 (+)17 bp
Tssr84433Chr9:40180570-40180599 (+)72 bp
Tssr84434Chr9:40180650-40180662 (+)143 bp
Tssr84435Chr9:40180675-40180719 (+)184 bp
Tssr84436Chr9:40180726-40180737 (+)219 bp
Tssr84437Chr9:40180747-40180768 (+)245 bp
Tssr84438Chr9:40180769-40180792 (+)268 bp
Tssr84439Chr9:40197387-40197391 (+)16,876 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support.		 last database update
10/07/2025
MGI 6.24		The Jackson Laboratory
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