Movatterモバイル変換

[0]ホーム
URL:

  About  Help  FAQ
Tbx19Gene Detail
Summary
  • Symbol
    Tbx19
  • Name
    T-box 19
  • Synonyms
    D1Ertd754e, Tpit
  • Feature Type
    protein coding gene
  • IDs
    MGI:1891158
    NCBI Gene:83993
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:164965424-164988342 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 72.47 cM, cytoband H2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1256from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_1891158
protein coding geneChr1:164965403-164988342 (-)
129S1/SvImJMGP_129S1SvImJ_G0016688
protein coding geneChr1:170605825-170631842 (-)
A/JMGP_AJ_G0016669
protein coding geneChr1:163650660-163676280 (-)
AKR/JMGP_AKRJ_G0016635
protein coding geneChr1:168603421-168628256 (-)
BALB/cJMGP_BALBcJ_G0016630
protein coding geneChr1:164142053-164164695 (-)
C3H/HeJMGP_C3HHeJ_G0016454
protein coding geneChr1:168823134-168848912 (-)
C57BL/6NJMGP_C57BL6NJ_G0017091
protein coding geneChr1:176332947-176359118 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0014800
protein coding geneChr1:155570351-155590738 (-)
CAST/EiJMGP_CASTEiJ_G0016034
protein coding geneChr1:168451736-168476130 (-)
CBA/JMGP_CBAJ_G0016429
protein coding geneChr1:182605385-182632769 (-)
DBA/2JMGP_DBA2J_G0016535
protein coding geneChr1:162542165-162565030 (-)
FVB/NJMGP_FVBNJ_G0016533
protein coding geneChr1:160995215-161020056 (-)
LP/JMGP_LPJ_G0016606
protein coding geneChr1:171684363-171708405 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0016558
protein coding geneChr1:190116472-190142186 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0017127
protein coding geneChr1:168454539-168478501 (-)
PWK/PhJMGP_PWKPhJ_G0015820
protein coding geneChr1:161742453-161766250 (-)
SPRET/EiJMGP_SPRETEiJ_G0015607
protein coding geneChr1:167318507-167342167 (-)
WSB/EiJMGP_WSBEiJ_G0016096
protein coding geneChr1:168614700-168637472 (-)



Homology
more
  • Human Ortholog
    TBX19, T-box transcription factor 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TBX19,T-box transcription factor 19
  • Synonyms
    dJ747L4.1, TBS19, TPIT
  • Links
    NCBI Gene ID:9095
    UniProt:O60806

  • Chr Location
    1q24.2; chr1:168280877-168314426(+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tbx19 mouse models;3 with human TBX19 associations

Human DiseaseMouse Models
    
IDs
adrenocorticotropic hormone deficiency      
View 1 model
Mouse Models

Human Disease Modeled: adrenocorticotropic hormone deficiency

Allelic CompositionGenetic BackgroundReferencePhenotypes
Tbx19tm1Jdr/Tbx19tm1Jdr
either: (involves: 129/Sv) or (involves: BALB/c)J:82561View
    
IDs
alcohol dependence      
IDs
inherited metabolic disorder      

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypesfrom 1 allelein 1 genetic background
    10 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The phenotype of homozygous null mice is similar to that of patients with early onset pituitary ACTH deficiency. They are characterized by fasting-induced hypoglycemia due to an impaired pituitary-adrenal axis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000026572Ensembl Gene Model |MGI Sequence Detail22919C57BL/6J± kb
transcriptENSMUST00000027859Ensembl |MGI Sequence Detail2660Not Applicable 
polypeptideENSMUSP00000027859Ensembl |MGI Sequence Detail446Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic25
    cDNA18
    Primer pair3
    Other4

    Microarray probesets4
Other
Accession IDs
less
MGI:1289162, MGI:2138434
References
more
  • Summaries
    All73
    Developmental Gene Expression40
    Diseases1
    Gene Ontology5
    Phenotypes10
  • Earliest
    J:54765 Bergstrom DE, et al., Genetic and physical mapping of the Dreher locus on mouse Chromosome 1. Genomics. 1999;59:291-9
  • Latest
    J:328469 Zhang J, et al., MicroRNA-7a2 is Required for the Development of Pituitary Stem Cells. Stem Cells Dev. 2022 Jul;31(13-14):357-368
TSS for Tbx19:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr14758Chr1:164988358-164988362 (-)-18 bp
Tssr14757Chr1:164988343-164988350 (-)-5 bp
Tssr14756Chr1:164988241-164988254 (-)94 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.		 last database update
03/25/2025
MGI 6.24		The Jackson Laboratory
This site uses cookies. Some cookies are essential for site operations and others help us analyze use and utility of our web site. Please refer to ourprivacy policy for more information.
CloseSave preferences
[8]ページ先頭
©2009-2025 Movatter.jp