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Cd59bGene Detail
Summary
  • Symbol
    Cd59b
  • Name
    CD59b antigen
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888996
    NCBI Gene:333883
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:103900127-103920619 bp, + strand
    From NCBI annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 2, 54.51 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    818from dbSNP Build 142
  • Strain Annotations
    16
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_1888996
protein coding geneChr2:103896142-103921534 (+)
129S1/SvImJMGP_129S1SvImJ_G0026214
protein coding geneChr2:106112087-106173935 (+)
A/JMGP_AJ_G0026174
protein coding geneChr2:101715859-101759324 (+)
AKR/JMGP_AKRJ_G0026153
protein coding geneChr2:104469784-104480621 (+)
BALB/cJMGP_BALBcJ_G0026183
protein coding geneChr2:101993681-102010159 (+)
C3H/HeJMGP_C3HHeJ_G0025934
protein coding geneChr2:104796387-104812323 (+)
C57BL/6NJMGP_C57BL6NJ_G0026634
protein coding geneChr2:109629919-109653944 (+)
CAROLI/EiJno annotation
CAST/EiJMGP_CASTEiJ_G0025398
protein coding geneChr2:105272742-105315903 (+)
CBA/Jno annotation
DBA/2JMGP_DBA2J_G0026049
protein coding geneChr2:101261071-101283963 (+)
FVB/NJMGP_FVBNJ_G0026011
protein coding geneChr2:100255845-100270796 (+)
LP/JMGP_LPJ_G0026152
protein coding geneChr2:106235054-106275754 (+)
NOD/ShiLtJMGP_NODShiLtJ_G0026036
protein coding geneChr2:117267863-117284831 (+)
NZO/HlLtJMGP_NZOHlLtJ_G0026688
protein coding geneChr2:104686469-104735374 (+)
PWK/PhJMGP_PWKPhJ_G0025133
protein coding geneChr2:100775740-100845592 (+)
SPRET/EiJMGP_SPRETEiJ_G0024933
protein coding geneChr2:103880528-103931268 (+)
WSB/EiJMGP_WSBEiJ_G0025465
protein coding geneChr2:105395445-105426313 (+)



Homology
more
  • Human Ortholog
    CD59, CD59 molecule (CD59 blood group)
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CD59,CD59 molecule (CD59 blood group)
  • Synonyms
    16.3A5, 1F5, EJ16, EJ30, EL32, G344, HRF-20, HRF20, MACIF, MAC-IP, MEM43, MIC11, MIN1, MIN2, MIN3, MIRL, MSK21, p18-20
  • Links
    NCBI Gene ID:966
    UniProt:P13987

  • Chr Location
    11p13; chr11:33703010-33736479(-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CD59 associations

Human DiseaseMouse Models
    
IDs
colorectal carcinoma      
IDs
ovarian cancer      

DOID:2394
DOID:0060070
DOID:2144
DOID:9595
ICD10CM:C56
ICD9CM:183.0
MESH:D010051
NCI:C4984
NCI:C7431
OMIM:167000
OMIM:607893
ORDO:213500
ORDO:213517
UMLS_CUI:C0919267
UMLS_CUI:C1140680
UMLS_CUI:C1299247


Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    26 phenotypesfrom 1 allelein 1 genetic background
    14 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation develop a severe hemolytic anemia and progressive male infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic333883NCBI Gene Model |MGI Sequence Detail20493C57BL/6J± kb
transcriptNM_001368215RefSeq |MGI Sequence Detail706C57BL/6 
polypeptideP58019UniProt |EBI |MGI Sequence Detail129Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic13
    cDNA8
    Primer pair5

    Microarray probesets2
References
more
  • Summaries
    All34
    Developmental Gene Expression2
    Gene Ontology7
    Phenotypes14
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:180268 Zhang J, et al., The protective role of CD59 and pathogenic role of complement in hepatic ischemia and reperfusion injury. Am J Pathol. 2011 Dec;179(6):2876-84
TSS for Cd59b:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr19203Chr2:103900164-103900183 (+)47 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support.		 last database update
03/25/2025
MGI 6.24		The Jackson Laboratory
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