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Il18rapGene Detail
Summary
  • Symbol
    Il18rap
  • Name
    interleukin 18 receptor accessory protein
  • Synonyms
    AcPL accessory protein-like)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338888
    NCBI Gene:16174
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:40554548-40590867 bp, + strand
    From NCBI annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 1, 19.37 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1237from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_1338888
protein coding geneChr1:40554522-40590867 (+)
129S1/SvImJMGP_129S1SvImJ_G0015969
protein coding geneChr1:39313874-39352831 (+)
A/JMGP_AJ_G0015953
protein coding geneChr1:38202158-38238842 (+)
AKR/JMGP_AKRJ_G0015908
protein coding geneChr1:38678088-38711965 (+)
BALB/cJMGP_BALBcJ_G0015907
protein coding geneChr1:37863404-37900017 (+)
C3H/HeJMGP_C3HHeJ_G0015740
protein coding geneChr1:38984419-39019544 (+)
C57BL/6NJMGP_C57BL6NJ_G0016360
protein coding geneChr1:40926776-40964159 (+)
CAROLI/EiJMGP_CAROLIEiJ_G0014082
protein coding geneChr1:35127870-35159264 (+)
CAST/EiJMGP_CASTEiJ_G0015321
protein coding geneChr1:38877004-38911438 (+)
CBA/JMGP_CBAJ_G0015712
protein coding geneChr1:42130199-42176404 (+)
DBA/2JMGP_DBA2J_G0015813
protein coding geneChr1:37478174-37515280 (+)
FVB/NJMGP_FVBNJ_G0015815
protein coding geneChr1:37023243-37058534 (+)
LP/JMGP_LPJ_G0015883
protein coding geneChr1:39648338-39685240 (+)
NOD/ShiLtJMGP_NODShiLtJ_G0015835
protein coding geneChr1:44140762-44180439 (+)
NZO/HlLtJMGP_NZOHlLtJ_G0016407
protein coding geneChr1:38837277-38872686 (+)
PWK/PhJMGP_PWKPhJ_G0015104
protein coding geneChr1:37291270-37327021 (+)
SPRET/EiJMGP_SPRETEiJ_G0014886
protein coding geneChr1:38812615-38845271 (+)
WSB/EiJMGP_WSBEiJ_G0015383
protein coding geneChr1:38805944-38841114 (+)



Homology
more
  • Human Ortholog
    IL18RAP, interleukin 18 receptor accessory protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    IL18RAP,interleukin 18 receptor accessory protein
  • Synonyms
    ACPL, CD218b, CDw218b, IL-18RAcP, IL18RB, IL-18R-beta, IL-18Rbeta, IL-1R-7, IL-1R7, IL-1RAcPL
  • Links
    NCBI Gene ID:8807
    neXtProt AC:NX_O95256
    UniProt:O95256

  • Chr Location
    2q12.1; chr2:102418621-102452565(+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypesfrom 3 allelesin 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit defective IL-18-mediated immune responses such as the inability of splenocytes, T helper 1 cells and neutrophils to produce cytokines in response to IL-18.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic16174NCBI Gene Model |MGI Sequence Detail36320C57BL/6J± kb
transcriptNM_010553RefSeq |MGI Sequence Detail4856C57BL/6 
polypeptideQ9Z2B1UniProt |EBI |MGI Sequence Detail614Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic7
    Genomic1
    cDNA4
    Primer pair1
    Other1

    Microarray probesets4
References
more
  • Summaries
    All39
    Developmental Gene Expression1
    Gene Ontology9
    Phenotypes13
  • Earliest
    J:50863 Born TL, et al., Cloning of a novel receptor subunit, AcPL, required for interleukin-18 signaling. J Biol Chem. 1998 Nov 6;273(45):29445-50
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
TSS for Il18rap:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr6477Chr1:40554537-40554591 (+)16 bp
Tssr6478Chr1:40554602-40554618 (+)62 bp
Tssr6479Chr1:40554631-40554643 (+)89 bp
Tssr65Chr1:40554655-40554662 (+)111 bp
Tssr6480Chr1:40568760-40568771 (+)14,218 bp
Tssr6481Chr1:40573685-40573694 (+)19,142 bp
Tssr6482Chr1:40582117-40582130 (+)27,576 bp
Tssr6483Chr1:40582144-40582151 (+)27,600 bp
Tssr6484Chr1:40582154-40582168 (+)27,613 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support.		 last database update
03/18/2025
MGI 6.24		The Jackson Laboratory
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