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Ndst1Gene Detail
Summary
  • Symbol
    Ndst1
  • Name
    N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
  • Synonyms
    1200015G06Rik, b2b2230Clo, glucosaminyl N-deacetylase/N-sulfotransferase 1, Hsst, Ndst-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:104719
    NCBI Gene:15531
  • Alliance
  • Transcription Start Sites
    15 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:60817566-60881722 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 18, 34.38 cM, cytoband D2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2016from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_104719
protein coding geneChr18:60817566-60907465 (-)
129S1/SvImJMGP_129S1SvImJ_G0024466
protein coding geneChr18:60509372-60550500 (-)
A/JMGP_AJ_G0024433
protein coding geneChr18:57915881-57956260 (-)
AKR/JMGP_AKRJ_G0024403
protein coding geneChr18:59516840-59544230 (-)
BALB/cJMGP_BALBcJ_G0024432
protein coding geneChr18:58049131-58076462 (-)
C3H/HeJMGP_C3HHeJ_G0024200
protein coding geneChr18:59748144-59775941 (-)
C57BL/6NJMGP_C57BL6NJ_G0024879
protein coding geneChr18:62166725-62194032 (-)
CAROLI/EiJMGP_CAROLIEiJ_G0022310
protein coding geneChr18:57470373-57498161 (-)
CAST/EiJMGP_CASTEiJ_G0023673
protein coding geneChr18:59610817-59640258 (-)
CBA/JMGP_CBAJ_G0024170
protein coding geneChr18:64182120-64213562 (-)
DBA/2JMGP_DBA2J_G0024300
protein coding geneChr18:57598759-57626352 (-)
FVB/NJMGP_FVBNJ_G0024266
protein coding geneChr18:56995182-57027047 (-)
LP/JMGP_LPJ_G0024383
protein coding geneChr18:60363892-60402551 (-)
NOD/ShiLtJMGP_NODShiLtJ_G0024295
protein coding geneChr18:65810822-65851417 (-)
NZO/HlLtJMGP_NZOHlLtJ_G0024926
protein coding geneChr18:59703470-59748642 (-)
PWK/PhJMGP_PWKPhJ_G0023416
protein coding geneChr18:57821207-57849507 (-)
SPRET/EiJMGP_SPRETEiJ_G0023222
protein coding geneChr18:59943082-59985906 (-)
WSB/EiJMGP_WSBEiJ_G0023737
protein coding geneChr18:59565040-59593468 (-)



Homology
more
  • Human Ortholog
    NDST1, N-deacetylase and N-sulfotransferase 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NDST1,N-deacetylase and N-sulfotransferase 1
  • Synonyms
    HSST, MRT46, NST1
  • Links
    NCBI Gene ID:3340
    UniProt:P52848

  • Chr Location
    5q33.1; chr5:150485818-150558211(+)  GRCh38
Human Diseases
more
  • Diseases
    3 with Ndst1 mouse models;1 with human NDST1 associations

Human DiseaseMouse Models
    
IDs
congenital diaphragmatic hernia      
View 1 model
Mouse Models

Human Disease Modeled: congenital diaphragmatic hernia

Allelic CompositionGenetic BackgroundReferencePhenotypes
Ndst1tm1Je/Ndst1tm1Je
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJLJ:208012View
IDs
DiGeorge syndrome      

DOID:11198
ICD10CM:D82.1
ICD9CM:279.11
MESH:D004062
NCI:C2989
OMIM:188400
UMLS_CUI:C0012236

View 1 model
Mouse Models

Human Disease Modeled: DiGeorge syndrome

Allelic CompositionGenetic BackgroundReferencePhenotypes
Ndst1b2b2230Clo/Ndst1b2b2230Clo
C57BL/6J-Ndst1b2b2230CloJ:175213View
IDs
newborn respiratory distress syndrome      

DOID:12716
DOID:11395
DOID:13859
ICD10CM:P22.0
MESH:D006819
OMIM:267450
UMLS_CUI:C0020192

View 2 models
Mouse Models

Human Disease Modeled: newborn respiratory distress syndrome

Allelic CompositionGenetic BackgroundReferencePhenotypes
Ndst1tm1Ekf/Ndst1tm1Ekf
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J:63996View
Ndst1tm1Hgx/Ndst1tm1Hgx
involves: 129S4/SvJae * C57BL/6J:60280View
    
IDs
autosomal recessive intellectual developmental disorder 46      

  • Mutations/Alleles
    4 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    70 phenotypesfrom 6 allelesin 8 genetic backgrounds
    31 phenotypes from multigenic genotypes
    20 images
    60 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die late in gestation or neonatally. Lungs fail to inflate and mice born alive experience respiratory distress and failure.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000054008Ensembl Gene Model |MGI Sequence Detail64157C57BL/6J± kb
transcriptENSMUST00000237783Ensembl |MGI Sequence Detail6478Not Applicable 
polypeptideENSMUSP00000158312Ensembl |MGI Sequence Detail882Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic24
    cDNA20
    Primer pair4

    Microarray probesets8
Other
Accession IDs
less
MGD-MRK-27082, MGI:1921391, MGI:5491170
References
more
  • Summaries
    All118
    Developmental Gene Expression16
    Diseases4
    Gene Ontology26
    Phenotypes60
  • Earliest
    J:17539 Eriksson I, et al., cDNA cloning and sequencing of mouse mastocytoma glucosaminyl N-deacetylase/N-sulfotransferase, an enzyme involved in the biosynthesis of heparin. J Biol Chem. 1994 Apr 8;269(14):10438-43
  • Latest
    J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
TSS for Ndst1:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr153489Chr18:60882080-60882093 (-)-365 bp
Tssr153488Chr18:60881680-60881766 (-)-1 bp
Tssr153487Chr18:60881405-60881482 (-)278 bp
Tssr153486Chr18:60880075-60880091 (-)1,639 bp
Tssr153485Chr18:60877744-60877755 (-)3,972 bp
Tssr153484Chr18:60866556-60866575 (-)15,156 bp
Tssr153483Chr18:60866531-60866553 (-)15,180 bp
Tssr153482Chr18:60866186-60866229 (-)15,514 bp
Tssr153481Chr18:60860594-60860644 (-)21,103 bp
Tssr153480Chr18:60856790-60856803 (-)24,925 bp
Tssr153479Chr18:60856770-60856786 (-)24,944 bp
Tssr153478Chr18:60851788-60851798 (-)29,929 bp
Tssr153477Chr18:60851760-60851778 (-)29,953 bp
Tssr153476Chr18:60851755-60851759 (-)29,965 bp
Tssr153475Chr18:60824803-60824834 (-)56,903 bp
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support.		 last database update
03/18/2025
MGI 6.24		The Jackson Laboratory
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