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Map3k11Gene Detail
Summary
  • Symbol
    Map3k11
  • Name
    mitogen-activated protein kinase kinase kinase 11
  • Synonyms
    2610017K16Rik, Mlk3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346880
    NCBI Gene:26403
  • Alliance
  • Transcription Start Sites
    5 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr19:5738770-5752893 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region inJBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 19, 4.34 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    163from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
StrainGene Model IDFeature TypeCoordinatesSelect Strains
C57BL/6JMGI_C57BL6J_1346880
protein coding geneChr19:5738764-5752893 (+)
129S1/SvImJMGP_129S1SvImJ_G0024722
protein coding geneChr19:2673540-2687271 (+)
A/JMGP_AJ_G0024688
protein coding geneChr19:2528257-2541991 (+)
AKR/JMGP_AKRJ_G0024661
protein coding geneChr19:2594696-2608430 (+)
BALB/cJMGP_BALBcJ_G0024688
protein coding geneChr19:2522652-2536386 (+)
C3H/HeJMGP_C3HHeJ_G0024456
protein coding geneChr19:2612943-2626677 (+)
C57BL/6NJMGP_C57BL6NJ_G0025135
protein coding geneChr19:2740696-2754919 (+)
CAROLI/EiJMGP_CAROLIEiJ_G0022565
protein coding geneChr19:2436991-2450802 (+)
CAST/EiJMGP_CASTEiJ_G0023928
protein coding geneChr19:2632328-2646078 (+)
CBA/JMGP_CBAJ_G0024428
protein coding geneChr19:2866671-2880385 (+)
DBA/2JMGP_DBA2J_G0024555
protein coding geneChr19:2524194-2537908 (+)
FVB/NJMGP_FVBNJ_G0024521
protein coding geneChr19:2521338-2535437 (+)
LP/JMGP_LPJ_G0024641
protein coding geneChr19:2649498-2663221 (+)
NOD/ShiLtJMGP_NODShiLtJ_G0024551
protein coding geneChr19:2711237-2724961 (+)
NZO/HlLtJMGP_NZOHlLtJ_G0025183
protein coding geneChr19:2614932-2628663 (+)
PWK/PhJMGP_PWKPhJ_G0023674
protein coding geneChr19:2546717-2560509 (+)
SPRET/EiJMGP_SPRETEiJ_G0023479
protein coding geneChr19:2599217-2612955 (+)
WSB/EiJMGP_WSBEiJ_G0023990
protein coding geneChr19:2624778-2638490 (+)



Homology
more
  • Human Ortholog
    MAP3K11, mitogen-activated protein kinase kinase kinase 11
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP3K11,mitogen-activated protein kinase kinase kinase 11
  • Synonyms
    MEKK11, MLK-3, MLK3, PTK1, SPRK
  • Links
    NCBI Gene ID:4296
    UniProt:Q16584

  • Chr Location
    11q13.1; chr11:65597756-65615382(-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypesfrom 2 allelesin 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    22 phenotype references
Phenotype Overview

Phenotype Overview
Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.
adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted or spontaneous mutation display a pattern of dark red stripes of thin dorsal epithelium during pre-wean development, and necrotic dental pulp has been reported for the spontaneous mutant.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

Expression Overview
GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.
  • Blue cells = expressed in wild-type.
    Gray triangles = other expression annotations only
    (e.g. absence of expression or data from mutants).
early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomicENSMUSG00000004054Ensembl Gene Model |MGI Sequence Detail14124C57BL/6J± kb
transcriptENSMUST00000004156Ensembl |MGI Sequence Detail3898Not Applicable 
polypeptideENSMUSP00000004156Ensembl |MGI Sequence Detail850Not Applicable 
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic12
    Genomic3
    cDNA8
    Other1

    Microarray probesets3
Other
Accession IDs
less
MGI:1095739, MGI:1923791
References
more
  • Summaries
    All67
    Developmental Gene Expression4
    Gene Ontology10
    Phenotypes22
  • Earliest
    J:37543 Kiefer F, et al., HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J. 1996 Dec 16;15(24):7013-25
  • Latest
    J:330866 Liu PW, et al., Mixed lineage kinase 3 requires a functional CRIB domain for regulation of blood pressure, cardiac hypertrophy, and left ventricular function. Am J Physiol Heart Circ Physiol. 2022 Sep 1;323(3):H513-H522
TSS for Map3k11:
(View these features inJBrowse)
Transcription Start SiteLocationDistance from Gene 5'-end
Tssr154475Chr19:5738751-5738798 (+)5 bp
Tssr154476Chr19:5738806-5738825 (+)46 bp
Tssr154477Chr19:5739773-5739851 (+)1,042 bp
Tssr154478Chr19:5742880-5742902 (+)4,121 bp
Tssr154479Chr19:5750798-5750823 (+)12,041 bp
Map3k11 is Candidate Gene for:
QTLGenetic Location*Genome Location (GRCm39)ReferenceQTL Note
Mtes1Chr19, syntenicJ:103849The authors showed a representation of approximately 110kb of gemomic mouse Chromosome 19. The markers were ordered as Centromere - Rela - Sipa1 - Pcnxl3 - Map3k11 - Kcnk7 - Telomere. Evidence is also provided using the two strains of mice with high metastatic efficiency (AKR/J and FVB/NJ) and the two strains with low metastatic efficiency (DBA/2J and NZB/B1NJ) that mouse Sipa1 may be a candidate for QTL Mtes1.
*cM position of peak correlated region/marker
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support.		 last database update
03/25/2025
MGI 6.24		The Jackson Laboratory
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