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Current Diabetes Reviews

Editor-in-Chief

ISSN (Print): 1573-3998
ISSN (Online): 1875-6417

Review Article

Insights into the Therapeutic uses of Plant Derive Phytocompounds onDiabetic Nephropathy

Author(s):Palash Mitra,Sahadeb Jana andSuchismita Roy*

Volume 20, Issue 9, 2024

Published on: 23 January, 2024

Article ID: e230124225973Pages: 15

DOI:10.2174/0115733998273395231117114600

Price: $65

TIMBC 2025
Abstract

Diabetic nephropathy (DN) is one of the primary consequences of diabetes mellitus,affecting many people worldwide and is the main cause of death under the age of sixty. Reactiveoxygen species (ROS) production rises during hyperglycemia and is crucial to the development ofdiabetic complications. Advanced glycation end products (AGEs) are produced excessively in adiabetic state and are accumulated in the kidney, where they change renal architecture and impairrenal function. Another important targeted pathway for the formation of DN includes nuclear factorkappa-B (NF-kB), Nuclear factor E2–related factor 2 (Nrf2), NLR family pyrin domain containing3 (NLRP3), protein kinase B/mammalian target of rapamycin (Akt/mTOR), and autophagy. About40% of individuals with diabetes eventually acquire diabetic kidney disease and end-stage renaldisease that needs hemodialysis, peritoneal dialysis, or kidney transplantation to survive. The currentstate of acceptable therapy for this kidney ailment is limited. The studies revealed that somenaturally occurring bioactive substances might shield the kidney by controlling oxidative stress,renal fibrosis, inflammation, and autophagy. In order to provide new potential therapeutic leadbioactive compounds for contemporary drug discovery and clinical management of DN, this reviewwas designed to examine the various mechanistic pathways by which conventional plantsderive phytocompounds that are effective for the control and treatment of DN

Keywords:Diabetic nephropathy, hyperglycemia, phytocompounds, end-stage renal disease, oxidative stress, inflammation.

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Current Diabetes Reviews

Title:Insights into the Therapeutic uses of Plant Derive Phytocompounds onDiabetic Nephropathy

Volume: 20Issue: 9

Author(s):Palash Mitra, Sahadeb Jana and Suchismita Roy*

Affiliation:

      • Nutrition Research Laboratory, Department of Paramedical and Allied Health Sciences, Midnapore City College, Kuturiya,Bhadutala, Midnapore 721129, India

      Keywords:Diabetic nephropathy, hyperglycemia, phytocompounds, end-stage renal disease, oxidative stress, inflammation.

      Abstract: Diabetic nephropathy (DN) is one of the primary consequences of diabetes mellitus,affecting many people worldwide and is the main cause of death under the age of sixty. Reactiveoxygen species (ROS) production rises during hyperglycemia and is crucial to the development ofdiabetic complications. Advanced glycation end products (AGEs) are produced excessively in adiabetic state and are accumulated in the kidney, where they change renal architecture and impairrenal function. Another important targeted pathway for the formation of DN includes nuclear factorkappa-B (NF-kB), Nuclear factor E2–related factor 2 (Nrf2), NLR family pyrin domain containing3 (NLRP3), protein kinase B/mammalian target of rapamycin (Akt/mTOR), and autophagy. About40% of individuals with diabetes eventually acquire diabetic kidney disease and end-stage renaldisease that needs hemodialysis, peritoneal dialysis, or kidney transplantation to survive. The currentstate of acceptable therapy for this kidney ailment is limited. The studies revealed that somenaturally occurring bioactive substances might shield the kidney by controlling oxidative stress,renal fibrosis, inflammation, and autophagy. In order to provide new potential therapeutic leadbioactive compounds for contemporary drug discovery and clinical management of DN, this reviewwas designed to examine the various mechanistic pathways by which conventional plantsderive phytocompounds that are effective for the control and treatment of DN

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      Cite this article as:

      Mitra Palash, Jana Sahadeb and Roy Suchismita*, Insights into the Therapeutic uses of Plant Derive Phytocompounds onDiabetic Nephropathy, Current Diabetes Reviews 2024; 20 (9) :e230124225973 .https://dx.doi.org/10.2174/0115733998273395231117114600

      DOI
      https://dx.doi.org/10.2174/0115733998273395231117114600      		Print ISSN
      1573-3998
      Publisher Name
      Bentham Science Publisher      		Online ISSN
      1875-6417

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