Abstract
Objectives: Patients with an autism spectrum disorder (ASD) are prone to disruptivebehaviors and aggression. A typical antipsychotics are used to treat these difficult ASD conditions.Several psychotropic drugs have been linked to hypothyroidism. The clinical manifestationof hypothyroidism is indistinguishable from that of an antipsychotic’s general adverse effect,which can lead to a delayed or missed diagnosis. Conversely, thyroid dysfunction can exhibitan impact on mood, anxiety, depression, and cognitive functions.
Case Presentation: We present a case of central hypothyroidism caused by long-term use ofvalproic acid (VPA) and adding quetiapine to risperidone. The current case had a history of hyperprolactinemiaand subclinical hypothyroidism caused by risperidone and VPA, respectively,before the administration of quetiapine.
Conclusion: This is the first report of quetiapine-induced central hypothyroidism in a patientwith ASD, as determined by a thyrotropin-releasing hormone (TRH) loading test. TRH loadingtest may be useful in elucidating the pathogenesis of hypothyroidism in patients receiving quetiapineand VPA. Thyroid function monitoring in patients taking quetiapine and VPA may providean opportunity to begin replacement therapy.
Keywords:Quetiapine, valproic acid, TRH loading test, central hypothyroidism, autism spectrum disorder, antipsychotics.
[http://dx.doi.org/10.1172/JCI32483] [PMID: 18172517]
[PMID:10811241]
[http://dx.doi.org/10.1002/jcph.1960] [PMID: 34467533]
[http://dx.doi.org/10.1345/aph.19186] [PMID: 10772436]
[http://dx.doi.org/10.1097/WNF.0b013e3181a8cbcc] [PMID: 19820433]
[http://dx.doi.org/10.1016/j.jaac.2020.01.018] [PMID: 32036034]
[http://dx.doi.org/10.1055/s-0030-1261880] [PMID: 20614417]
[http://dx.doi.org/10.1345/aph.1E054] [PMID: 15252194]
[http://dx.doi.org/10.4158/EP12415.CR] [PMID: 23757611]
[http://dx.doi.org/10.1016/j.genhosppsych.2010.11.008]
[http://dx.doi.org/10.1097/01.jcp.0000203227.56494.ff] [PMID: 16633154]
[http://dx.doi.org/10.2147/NDT.S120509] [PMID: 29296085]
[http://dx.doi.org/10.1097/WNF.0b013e31823429a7] [PMID: 21996646]
[http://dx.doi.org/10.1111/j.1365-2265.1979.tb03028.x] [PMID: 436307]
[http://dx.doi.org/10.1210/jcem-41-5-985] [PMID: 810492]
[http://dx.doi.org/10.1111/j.0013-9580.2004.26003.x] [PMID: 15009219]
[http://dx.doi.org/10.1186/s12888-016-1103-3] [PMID: 27829454]
[http://dx.doi.org/10.1007/s40263-014-0157-3] [PMID: 24677189]
[http://dx.doi.org/10.1016/S0893-133X(02)00314-7] [PMID: 12093603]
[http://dx.doi.org/10.1007/s002130050492] [PMID: 9497016]
[http://dx.doi.org/10.1007/s11102-008-0122-6]
[http://dx.doi.org/10.1089/thy.1998.8.903] [PMID: 9827657]
[http://dx.doi.org/10.1089/thy.2006.0311] [PMID: 17614773]
Endocrine, Metabolic & Immune Disorders - Drug Targets
Title:Quetiapine and Valproic Acid-induced Central Hypothyroidism in aPatient with Autism Spectrum Disorder and Intractable Epilepsy: A CaseReport
Volume: 24Issue: 13
Author(s):Narantsatsral Daramjav, Junko Takagi*, Hideyuki Iwayama, Kousuke Kanemoto and Kazuo Otake
Affiliation:
- Division of Endocrinology and Metabolism, Department of Internal Medicine, Aichi Medical University School of Medicine,Nagakute, Aichi, Japan
Keywords:Quetiapine, valproic acid, TRH loading test, central hypothyroidism, autism spectrum disorder, antipsychotics.
Abstract:
Objectives: Patients with an autism spectrum disorder (ASD) are prone to disruptivebehaviors and aggression. A typical antipsychotics are used to treat these difficult ASD conditions.Several psychotropic drugs have been linked to hypothyroidism. The clinical manifestationof hypothyroidism is indistinguishable from that of an antipsychotic’s general adverse effect,which can lead to a delayed or missed diagnosis. Conversely, thyroid dysfunction can exhibitan impact on mood, anxiety, depression, and cognitive functions.
Case Presentation: We present a case of central hypothyroidism caused by long-term use ofvalproic acid (VPA) and adding quetiapine to risperidone. The current case had a history of hyperprolactinemiaand subclinical hypothyroidism caused by risperidone and VPA, respectively,before the administration of quetiapine.
Conclusion: This is the first report of quetiapine-induced central hypothyroidism in a patientwith ASD, as determined by a thyrotropin-releasing hormone (TRH) loading test. TRH loadingtest may be useful in elucidating the pathogenesis of hypothyroidism in patients receiving quetiapineand VPA. Thyroid function monitoring in patients taking quetiapine and VPA may providean opportunity to begin replacement therapy.
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Cite this article as:
Daramjav Narantsatsral, Takagi Junko*, Iwayama Hideyuki, Kanemoto Kousuke and Otake Kazuo, Quetiapine and Valproic Acid-induced Central Hypothyroidism in aPatient with Autism Spectrum Disorder and Intractable Epilepsy: A CaseReport, Endocrine, Metabolic & Immune Disorders - Drug Targets 2024; 24 (13) .https://dx.doi.org/10.2174/0118715303261457231120114231
| DOI https://dx.doi.org/10.2174/0118715303261457231120114231 | Print ISSN 1871-5303 |
| Publisher Name Bentham Science Publisher | Online ISSN 2212-3873 |
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