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Abstract

Background: Plant phenolics, commonly present in legumes, leafy vegetables, fruits,grains are a key source of bioactive nutrients existing as flavonols, flavanones, flavanols, phytosterols,among others. Peanuts, being crops of high commercial use, undergo processing that generatesvoluminous agro-wastes. The waste comprises both the shells and skins, which could be valorized.Its versatile functionality has encouraged extensive research into peanut skin-derived chemicalsfor diverse applications over the past few decades. Peanut skin, however, is ascertained to berich in flavonoids, stilbenes (resveratrol), and other phenolic compounds.

Methods: This review presents the biologically active compounds and pharmacological activitiesof peanut skins and their related works over the past few years. Articles carefully chosen frombroad databases such as Scopus, Science Direct, Pub Med, SciFinder, among others, were used asthe primary data.

Results: The bioactive components of peanut skin extracts exhibit anti-oxidant, anti-inflammatory,anti-bacterial, anti-viral, anti-fungal, anti-cancer/anti-tumour, anti-cardiovascular, and anti-diabetes/obesity activities via in vitro and in vivo models. Besides, their varied biological propertiesmake them potential precursors for the management of diverse diseases and ailments.Potential Applications: Phytochemicals from peanut skins could be deployed as antioxidant, antidiabeticand antimicrobial agents in drugs for the clinical treatment of ailments with extensive clinicalapplications.

Conclusion: The present review covers the chemistry and pharmacological activities of peanutskin phytochemicals. Our findings in this review substantiate the importance of peanut skin extractsand their varied potential for the treatment of specific diseases. The results indicate that theyare attractive target compounds for the development of new drugs. We hope that this informationwill inform further in vivo studies on the role of peanut skin phenolic compounds in our health.

Keywords:Agro-wastes, peanut skin, phenolic compounds, bioactive components, pharmacological activity, in vivo.

Graphical Abstract

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Bioactive Compounds: An Ideal Source for Drug Discovery, Design, Development and Target Identification

The Special Issue "Bioactive Compounds: Discovery, Design, Development, and Target Identification" aims to bring together innovative research and critical reviews on bioactive molecules that show therapeutic potential across diverse diseases. Discovery of novel bioactive compounds will focus on uncovering new molecules from natural or synthetic sources, expanding the library of ...read more

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