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Recent Patents on Anti-Cancer Drug Discovery

Editor-in-Chief

ISSN (Print): 1574-8928
ISSN (Online): 2212-3970

Review Article

Chimeric Antigen Receptor T Cell Immunotherapy for Tumor: A Review of Patent Literatures

Author(s):Manxue Fu andLiling Tang*

Volume 14, Issue 1, 2019

Page: [60 - 69]Pages: 10

DOI:10.2174/1574892814666190111120908

TIMBC 2025
Abstract

Background: Chimeric Antigen Receptor (CAR) T cell immunotherapy, as an innovativemethod for tumor immunotherapy, acquires unprecedented clinical outcomes. Genetic modification notonly provides T cells with the antigen-binding function but also endows T cells with better immunologicalfunctions both in solid and hematological cancer. However, the CAR T cell therapy is not perfectbecause of several reasons, such as tumor immune microenvironment, and autologous limiting factors ofCAR T cells. Moreover, the safety of CAR T cells should be improved.

Objective: Recently many patents and publications have reported the importance of CAR T cell immunotherapy.Based on the patents about CAR T cell immunotherapy, we conclude some methods for designingthe CAR which can provide information to readers.

Methods: In this review, we collect recent patents and publications, summarize some specific antigensfor oncotherapy from patents and enumerate some approaches to conquering immunosuppression andreinforcing the immune response of CAR T cells. We also sum up some strategies for improving thesafety of CAR T cell immunotherapy.

Results: CAR T cell immunotherapy as a neotype cellular immunotherapy has been proved effective inoncotherapy and authorized by FDA. Improvements in CAR designing enhance functions of CAR T cells.

Conclusion: This review, summarizing antigens and approaches to overcome defects of CAR T cellimmunotherapy from patents and publications, might contribute to a broad readership.

Keywords:Antigen, CAR T cells, efficiency, immune checkpoints, immune therapy, safety.

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Recent Patents on Anti-Cancer Drug Discovery

Title:Chimeric Antigen Receptor T Cell Immunotherapy for Tumor: A Review of Patent Literatures

Volume: 14Issue: 1

Author(s):Manxue Fu and Liling Tang*

Affiliation:

    • Key Laboratory of Biorheological Science and Technology, Ministry of Education, College of Bioengineering, Chongqing University, P.R. China. Address: No.174 Shazhengjie, Shapingba, Chongqing,China

    Keywords:Antigen, CAR T cells, efficiency, immune checkpoints, immune therapy, safety.

    Abstract: Background: Chimeric Antigen Receptor (CAR) T cell immunotherapy, as an innovativemethod for tumor immunotherapy, acquires unprecedented clinical outcomes. Genetic modification notonly provides T cells with the antigen-binding function but also endows T cells with better immunologicalfunctions both in solid and hematological cancer. However, the CAR T cell therapy is not perfectbecause of several reasons, such as tumor immune microenvironment, and autologous limiting factors ofCAR T cells. Moreover, the safety of CAR T cells should be improved.

    Objective: Recently many patents and publications have reported the importance of CAR T cell immunotherapy.Based on the patents about CAR T cell immunotherapy, we conclude some methods for designingthe CAR which can provide information to readers.

    Methods: In this review, we collect recent patents and publications, summarize some specific antigensfor oncotherapy from patents and enumerate some approaches to conquering immunosuppression andreinforcing the immune response of CAR T cells. We also sum up some strategies for improving thesafety of CAR T cell immunotherapy.

    Results: CAR T cell immunotherapy as a neotype cellular immunotherapy has been proved effective inoncotherapy and authorized by FDA. Improvements in CAR designing enhance functions of CAR T cells.

    Conclusion: This review, summarizing antigens and approaches to overcome defects of CAR T cellimmunotherapy from patents and publications, might contribute to a broad readership.

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    Cite this article as:

    Fu Manxue and Tang Liling *, Chimeric Antigen Receptor T Cell Immunotherapy for Tumor: A Review of Patent Literatures, Recent Patents on Anti-Cancer Drug Discovery 2019; 14 (1) .https://dx.doi.org/10.2174/1574892814666190111120908

    DOI
    https://dx.doi.org/10.2174/1574892814666190111120908
    Print ISSN
    1574-8928
    Publisher Name
    Bentham Science Publisher
    Online ISSN
    2212-3970
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