Abstract
The chemistry of heterocyclic containing, 1,3,4-thiadiazole has been an interesting field of study fromancient years. Subsequently, 1,3,4-thiadiazole nucleus constitutes a significant class of compounds for new drugdevelopment. Recently, various 1,3,4-thiadiazole derivatives synthesized and evaluated their biological activitiesincluding antimicrobial, antituberculosis, antioxidant, anti-inflammatory, anticonvulsants, antidepressant andanxiolytic, antihypertensive, anticancer and antifungal activity. The search for anticancer compounds with moreselective activities and lower side effect continues to be an active area of argument examination in medicinalchemistry. This review elaborately described the medicinal chemistry, their structural activity relationship, andanticancer properties with respect to human cell line based approach related to synthesized 1,3,4-thiadiazolederivatives.
Keywords:1,3,4-thiadiazole, cancer cell lines, structure-activity-relationship, mechanism of action.
Anti-Cancer Agents in Medicinal Chemistry
Title:Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review
Volume: 17Issue: 4
Author(s):Vinit Raj, Amit Rai and Sudipta Saha*
Affiliation:
- Department of Pharmaceutical Sciences, Babasaheb Bhimrao Ambedkar University, VidyaVihar, Rai Bareli Road, Lucknow-226025,India
Keywords:1,3,4-thiadiazole, cancer cell lines, structure-activity-relationship, mechanism of action.
Abstract: The chemistry of heterocyclic containing, 1,3,4-thiadiazole has been an interesting field of study fromancient years. Subsequently, 1,3,4-thiadiazole nucleus constitutes a significant class of compounds for new drugdevelopment. Recently, various 1,3,4-thiadiazole derivatives synthesized and evaluated their biological activitiesincluding antimicrobial, antituberculosis, antioxidant, anti-inflammatory, anticonvulsants, antidepressant andanxiolytic, antihypertensive, anticancer and antifungal activity. The search for anticancer compounds with moreselective activities and lower side effect continues to be an active area of argument examination in medicinalchemistry. This review elaborately described the medicinal chemistry, their structural activity relationship, andanticancer properties with respect to human cell line based approach related to synthesized 1,3,4-thiadiazolederivatives.
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Raj Vinit, Rai Amit and Saha Sudipta*, Human Cancer Cell Line Based Approach of 1,3,4-thiadiazole and its Fused Ring: A Comprehensive Review, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (4) .https://dx.doi.org/10.2174/1871520616666161013150151
| DOI https://dx.doi.org/10.2174/1871520616666161013150151 | Print ISSN 1871-5206 |
| Publisher Name Bentham Science Publisher | Online ISSN 1875-5992 |
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