Abstract
Diseases associated with chronic inflammatory pathology claim a major share of worldwide deaths each year. A principal reasonbehind the huge number of casualties is associated with mild or unnoticed symptoms for long period of time since the outset, and thatspecific treatment options for these diseases have not yet emerged. Current anti-inflammatory drugs essentially have become ineffectivefor long term protection from these diseases as they also interfere with essential cellular pathways and associated toxicities. Notably, recentstudies with a number of phytochemicals have shown promising results. These compounds isolated from various medicinal plantsexpress their anti-inflammatory activities by down regulating expression of several crucial pro-inflammatory mediators. These are mostlyantioxidants; inhibit induction of key transcription factors like nuclear factor kappa B (NF-κB) that are responsible for expression of proinflammatorymediators, and other growth regulators. Definitely, some of these compounds have the potential to be developed into newtherapeutic agents to better control inflammation associated diseases in near future. This review summarizes recent findings on the molecularmechanisms through which various inflammatory activities are linked to disease progression and a group of natural products thathave shown promise in controlling these processes.
Keywords:Inflammation, natural products, nuclear factor kappa B (NF-κB), toll like receptor (TLR), cytokines, interleukin.
Current Pharmaceutical Design
Title:Chronic Inflammatory Diseases: Progress and Prospect with Herbal Medicine
Volume: 22Issue: 2
Author(s):Nilanjan Ghosh, Asif Ali, Rituparna Ghosh, Shaileyee Das, Subhash C. Mandal and Mahadeb Pal
Affiliation:
Keywords:Inflammation, natural products, nuclear factor kappa B (NF-κB), toll like receptor (TLR), cytokines, interleukin.
Abstract: Diseases associated with chronic inflammatory pathology claim a major share of worldwide deaths each year. A principal reasonbehind the huge number of casualties is associated with mild or unnoticed symptoms for long period of time since the outset, and thatspecific treatment options for these diseases have not yet emerged. Current anti-inflammatory drugs essentially have become ineffectivefor long term protection from these diseases as they also interfere with essential cellular pathways and associated toxicities. Notably, recentstudies with a number of phytochemicals have shown promising results. These compounds isolated from various medicinal plantsexpress their anti-inflammatory activities by down regulating expression of several crucial pro-inflammatory mediators. These are mostlyantioxidants; inhibit induction of key transcription factors like nuclear factor kappa B (NF-κB) that are responsible for expression of proinflammatorymediators, and other growth regulators. Definitely, some of these compounds have the potential to be developed into newtherapeutic agents to better control inflammation associated diseases in near future. This review summarizes recent findings on the molecularmechanisms through which various inflammatory activities are linked to disease progression and a group of natural products thathave shown promise in controlling these processes.
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Cite this article as:
Ghosh Nilanjan, Ali Asif, Ghosh Rituparna, Das Shaileyee, Mandal C. Subhash and Pal Mahadeb, Chronic Inflammatory Diseases: Progress and Prospect with Herbal Medicine, Current Pharmaceutical Design 2016; 22 (2) .https://dx.doi.org/10.2174/1381612822666151112151419
| DOI https://dx.doi.org/10.2174/1381612822666151112151419 | Print ISSN 1381-6128 |
| Publisher Name Bentham Science Publisher | Online ISSN 1873-4286 |
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