Abstract
MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, haveemerged to play a critical role in the pathogenesis of a variety of diseases. Current technological advances allow accurate,high throughput profiling of miRNA abundance in different tissues. More recently, extracellular, circulating miRNAshave begun to be demonstrated as highly stable, blood-based biomarkers for diseases. Understanding the interactions betweencirculating miRNAs and clinical phenotypes can enhance our knowledge of complex diseases and traits. On theother hand, given the advantages of utilizing blood-based biomarkers (e.g., convenience in collecting samples), circulatingmiRNAs as biomarkers may improve both disease diagnosis and management. Particularly, we reviewed recent progressin identifying circulating miRNAs as biomarkers for several common inflammatory diseases including asthma, inflammatorybowel disease, and rheumatoid arthritis. Current studies showed a promising future of using circulating miRNAs inthe care of inflammatory diseases.
Keywords:Asthma, biomarkers, circulating markers, inflammatory bowl disease, microRNA, rheumatoid arthritis.
MicroRNA
Title:Circulating MicroRNAs as Biomarkers for Inflammatory Diseases
Volume: 2Issue: 1
Author(s):Shuangli Mi, Jian Zhang, Wei Zhang and R. Stephanie Huang
Affiliation:
Keywords:Asthma, biomarkers, circulating markers, inflammatory bowl disease, microRNA, rheumatoid arthritis.
Abstract: MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, haveemerged to play a critical role in the pathogenesis of a variety of diseases. Current technological advances allow accurate,high throughput profiling of miRNA abundance in different tissues. More recently, extracellular, circulating miRNAshave begun to be demonstrated as highly stable, blood-based biomarkers for diseases. Understanding the interactions betweencirculating miRNAs and clinical phenotypes can enhance our knowledge of complex diseases and traits. On theother hand, given the advantages of utilizing blood-based biomarkers (e.g., convenience in collecting samples), circulatingmiRNAs as biomarkers may improve both disease diagnosis and management. Particularly, we reviewed recent progressin identifying circulating miRNAs as biomarkers for several common inflammatory diseases including asthma, inflammatorybowel disease, and rheumatoid arthritis. Current studies showed a promising future of using circulating miRNAs inthe care of inflammatory diseases.
Export Options
About this article
Cite this article as:
Mi Shuangli, Zhang Jian, Zhang Wei and Huang R. Stephanie, Circulating MicroRNAs as Biomarkers for Inflammatory Diseases, MicroRNA 2013; 2 (1) .https://dx.doi.org/10.2174/2211536611302010007
| DOI https://dx.doi.org/10.2174/2211536611302010007 | Print ISSN 2211-5366 |
| Publisher Name Bentham Science Publisher | Online ISSN 2211-5374 |
Call for Papers in Thematic Issues
Revolutionizing Animal Farming: The Impact of miRNAs on Health and Productivity
The utilization of microRNAs (miRNAs) in animal production represents an emerging frontier in agricultural biotechnology, with the potential to revolutionize the sector. MiRNAs, small non-coding RNA molecules, play a crucial role in regulating gene expression, influencing vital processes such as growth, muscle development, disease resistance, and feed efficiency. Their application ...read more
Related Journals
Related Books
Medicinal Plants of Pilibhit Tiger Reserve (PTR) India
Plant-Microbe Interactions: A Comprehensive Review
Glycosylation and Glycation in Health and Diseases
Phytogenic and Phytochemical as Alternative Feed Additives for Animal Production
Methods and Techniques in Nematology
Mind Maps in Clinical Biochemistry
A Treatise on Ecological Science
From SARS-CoV to MARS-CoV
Microbiology for ICAR NET: A Comprehensive Exam Preparation Guide
Decolorization by Thanatephorus Cucumeris Dec 1
69
- Author Guidelines
- Bentham Author Support Services (BASS)
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
- Microwave Assisted Synthesis of Five Membered Azaheterocyclic Systems
Current Organic ChemistryEngineered Polymer Nanoplatforms for Targeted Tumor Cells and Controlled Release Cargos to Enhance Cancer Treatment
Current Medicinal Chemistry Rheumatoid Arthritis in Southern Europe: Epidemiological, Clinical, Radiological and Genetic Considerations
Current Rheumatology ReviewsThe Structure–property Relationships of Clinically Approved ProteinKinase Inhibitors
Current Medicinal Chemistry Aspartate and Glutamate Mimetic Structures in Biologically Active Compounds
Current Medicinal ChemistryRecent Patents on Novel P2X7 Receptor Antagonists Potentially Effective for Treatment of Inflammatory Diseases
Recent Patents on Biomarkers The Forkhead Transcription Factor FOXO3a Controls Microglial Inflammatory Activation and Eventual Apoptotic Injury through Caspase 3
Current Neurovascular ResearchAnti-Cancer Compounds Targeted to VDAC: Potential and Perspectives
Current Medicinal ChemistryOfatumumab: A Novel Anti-CD20 Monoclonal Antibody for the Treatment of Chronic Lymphocytic Leukemia
Current Drug TherapyModified Polysaccharides as Versatile Materials in Controlled Delivery of Antidegenerative Agents
Current Pharmaceutical Design Translocator Protein Ligands as Promising Therapeutic Tools for Anxiety Disorders
Current Medicinal ChemistryNatural Products as Promising Drug Candidates for the Treatment of Alzheimer’s Disease: Molecular Mechanism Aspect
Current Neuropharmacology Role of PI3 Kinase Gamma in Excitation-Contraction Coupling and Heart Disease
Cardiovascular & Hematological Disorders-Drug TargetsSynthesis, Characterization and Evaluation of 1,3-Bisindolyl-2-Propen-1- One Derivatives as Potent Anti-Breast Cancer Agents
Current Bioactive Compounds Impact of Sphingosine Kinase on Inflammatory Pathways in Fibroblast-Like Synoviocytes
Inflammation & Allergy - Drug Targets (Discontinued) The Therapeutic Potential of ADAM15
Current Pharmaceutical DesignAn Overview on Natural Polysaccharides with Antioxidant Properties
Current Medicinal Chemistry Aging and Oral Health: Effects in Hard and Soft Tissues
Current Pharmaceutical DesignSynthesis and Immunomodulation of Human Lymphocyte Proliferation and Cytokine (Interferon-γ) Production of Four Novel Leflunomide Analogues
Medicinal ChemistryA Review on Skin Targeted Delivery of Bioactives as Ultradeformable Vesicles: Overcoming the Penetration Problem
Current Drug Targets
[8]ページ先頭