Abstract
Oxygen (O2) is a vital element. Shortage of O2 results in deranged metabolism and important changes in vasculartone with opposite effects on the systemic and pulmonary circulation. During hypoxemia, oxidative stress exposes theorganism to a sort of accelerated senescence as well as to several acute untoward effects. Thus, hypoxemia should bepromptly recognized and treated, hopefully by measures tailored to the pathophysiological mechanisms underlying hypoxemia.However, O2 therapy remains the most common therapy of hypoxemia, but it must be carefully tailored to relievehypoxemia without provoking hyperoxia or hypercarbia. Then, the individual response to O2 as well as changingneeds of O2 during sleep or exercise must be evaluated to provide the best O2 therapy. Hyperoxia, the effect of overcorrectionof hypoxia, can dramatically impact the health status and threaten the survival of the newborn and, through differentmechanisms and effects, the adult. A thorough knowledge of the pathophysiological bases of hypoxemia and O2 storageand delivery devices is then mandatory to administer O2 therapy guaranteeing for optimal correction of hypoxemia andminimizing the risk of hyperoxia. Consistent with this aim also is a careful scrutiny of instruments and procedures formonitoring the individual response to O2 over time. Thus, at variance from classical pharmacological therapy, performingO2 therapy requires a vast array of clinical and technical competences. The optimal integration of these competences isneeded to optimize O2 therapy on individual bases.
Keywords:Aging, haemodynamics, hypercarbia, hyperoxia, hypoxemia, lung, oxidative stress, oxygen, pulse oximetry, therapy
Current Medicinal Chemistry
Title:The Oxygen Therapy
Volume: 20Issue: 9
Author(s):A. Corsonello, C. Pedone, S. Scarlata, A. Zito, I. Laino and R. Antonelli-Incalzi
Affiliation:
Keywords:Aging, haemodynamics, hypercarbia, hyperoxia, hypoxemia, lung, oxidative stress, oxygen, pulse oximetry, therapy
Abstract: Oxygen (O2) is a vital element. Shortage of O2 results in deranged metabolism and important changes in vasculartone with opposite effects on the systemic and pulmonary circulation. During hypoxemia, oxidative stress exposes theorganism to a sort of accelerated senescence as well as to several acute untoward effects. Thus, hypoxemia should bepromptly recognized and treated, hopefully by measures tailored to the pathophysiological mechanisms underlying hypoxemia.However, O2 therapy remains the most common therapy of hypoxemia, but it must be carefully tailored to relievehypoxemia without provoking hyperoxia or hypercarbia. Then, the individual response to O2 as well as changingneeds of O2 during sleep or exercise must be evaluated to provide the best O2 therapy. Hyperoxia, the effect of overcorrectionof hypoxia, can dramatically impact the health status and threaten the survival of the newborn and, through differentmechanisms and effects, the adult. A thorough knowledge of the pathophysiological bases of hypoxemia and O2 storageand delivery devices is then mandatory to administer O2 therapy guaranteeing for optimal correction of hypoxemia andminimizing the risk of hyperoxia. Consistent with this aim also is a careful scrutiny of instruments and procedures formonitoring the individual response to O2 over time. Thus, at variance from classical pharmacological therapy, performingO2 therapy requires a vast array of clinical and technical competences. The optimal integration of these competences isneeded to optimize O2 therapy on individual bases.
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Corsonello A., Pedone C., Scarlata S., Zito A., Laino I. and Antonelli-Incalzi R., The Oxygen Therapy, Current Medicinal Chemistry 2013; 20 (9) .https://dx.doi.org/10.2174/0929867311320090002
| DOI https://dx.doi.org/10.2174/0929867311320090002 | Print ISSN 0929-8673 |
| Publisher Name Bentham Science Publisher | Online ISSN 1875-533X |
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