PDBsum

PDBsum is a pictorial database that provides an at-a-glanceoverview of the contents of each 3D structure deposited in the ProteinData Bank (PDB). It shows the molecule(s) that make up the structure (ie proteinchains, DNA, ligands and metal ions) and schematic diagrams of theinteractions between them.
Also included are theAlphaFoldpredicted models for all human protein forcomparison with experimentally determined structures. Read more ...

The SARS-CoV-2 virus genome has 14 open reading frames coding for at least 29 protein: four structural proteins, making the outer coat and its characteristic protruding spikes, sixteen or more non-structural proteins involved in the virus's replication, and nine accessory proteins that are thought to counteract the host's immune response.

Many of the proteins have been structurally determined and deposited in thePDB. Three examples are shown below.

For the full list, go toCOVID-19 protein structures

Spike protein. The spikes on the surface of the virus bind to specific host cell receptors and initiate cell infection. The structure shows a trimeric complex of the spike glycoprotein (in its closed state).
PDB entry6vxx
Pubmed ref32155444

Main protease responsible for cleaving the mainpolyprotein into its separate non-structural proteins, here shown with a bound inhibitor.
PDB entry5r81

RNA-binding domain of the nucleocapsid phosphoprotein. Tetrameric complex of N-terminal domains of the protein which is a facilitator for reverse transcription and integration.
PDB entry6vyo

Contents

PDBsum contains
entries, including
superseded