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Abstract
A flavanol glycoside, glucodistylin (1) and three polyphenol derivatives, gallate (2), (+)-catechin (3) and (+)-gallocatechin (4) were isolated from an aqueous acetone extract of the bark ofQuercus acutissima. Of these compounds, glucodistylin exhibited uncompetitive inhibitory activity against recombinant human aldose reductase with an IC50 value of 7.2 μM. Furthermore, glucodistylin inhibited sorbitol accumulation by 48.84% at 50 μM. This flavonoid showed therapeutic potential in the prevention and treatment of diabetes-related complications.
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Authors and Affiliations
Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, 200-702, Korea
Yeon Sil Lee & Soon Sung Lim
Institute of Natural Medicine, Hallym University, Chuncheon, 200-702, Korea
Jin Kyu Kim, Moo-Ho Won & Soon Sung Lim
Departement of Forest Biomaterials Engineering, Kangwon National University, Chuncheon, 200-701, Korea
Young Soo Bae
Department of Anatomy and Neurobiology, Hallym Univertisy, Chuncheon, 200-701, Korea
Moo-Ho Won
Department of Food Science and Nutrition, Hallym University, Chuncheon, 200-702, Korea
Il-Jun Kang & Soon Sung Lim
- Yeon Sil Lee
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- Jin Kyu Kim
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- Young Soo Bae
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- Moo-Ho Won
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- Il-Jun Kang
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- Soon Sung Lim
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Correspondence toSoon Sung Lim.
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Lee, Y.S., Kim, J.K., Bae, Y.S.et al. Inhibitory effect of glucodistylin from the bark ofQuercus acutissima on human recombinant aldose reductase and sorbitol accumulation.Arch. Pharm. Res.34, 211–215 (2011). https://doi.org/10.1007/s12272-011-0205-1
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