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Inhibitory effect of glucodistylin from the bark ofQuercus acutissima on human recombinant aldose reductase and sorbitol accumulation

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  • Drug Discovery and Development
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Abstract

A flavanol glycoside, glucodistylin (1) and three polyphenol derivatives, gallate (2), (+)-catechin (3) and (+)-gallocatechin (4) were isolated from an aqueous acetone extract of the bark ofQuercus acutissima. Of these compounds, glucodistylin exhibited uncompetitive inhibitory activity against recombinant human aldose reductase with an IC50 value of 7.2 μM. Furthermore, glucodistylin inhibited sorbitol accumulation by 48.84% at 50 μM. This flavonoid showed therapeutic potential in the prevention and treatment of diabetes-related complications.

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Authors and Affiliations

  1. Center for Efficacy Assessment and Development of Functional Foods and Drugs, Hallym University, Chuncheon, 200-702, Korea

    Yeon Sil Lee & Soon Sung Lim

  2. Institute of Natural Medicine, Hallym University, Chuncheon, 200-702, Korea

    Jin Kyu Kim, Moo-Ho Won & Soon Sung Lim

  3. Departement of Forest Biomaterials Engineering, Kangwon National University, Chuncheon, 200-701, Korea

    Young Soo Bae

  4. Department of Anatomy and Neurobiology, Hallym Univertisy, Chuncheon, 200-701, Korea

    Moo-Ho Won

  5. Department of Food Science and Nutrition, Hallym University, Chuncheon, 200-702, Korea

    Il-Jun Kang & Soon Sung Lim

Authors
  1. Yeon Sil Lee
  2. Jin Kyu Kim
  3. Young Soo Bae
  4. Moo-Ho Won
  5. Il-Jun Kang
  6. Soon Sung Lim

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Correspondence toSoon Sung Lim.

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Lee, Y.S., Kim, J.K., Bae, Y.S.et al. Inhibitory effect of glucodistylin from the bark ofQuercus acutissima on human recombinant aldose reductase and sorbitol accumulation.Arch. Pharm. Res.34, 211–215 (2011). https://doi.org/10.1007/s12272-011-0205-1

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