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Summary
Dibenzo [cd, jk] pyrene (anthanthrene), considered to be noncarcinogenic, was examined for carcinogenicity in a comparative study with other polycyclic hydrocarbons. Anthanthrene induced benign and malignant epidermal neoplasms in female Swiss mice after repeated skin application. The incidence of these tumors (47%) was lower and the latency longer than those found after benzo[a]pyrene or dibenzo[a,h]pyrene treatment. Since the proportion of malignant neoplasms was similar (60%) in these three groups, the results indicate that anthanthrene is a relatively strong carcinogen. A rationale accounting for previous negative results in percutaneous experiments with this compound is suggested.
Zusammenfassung
Das als nicht-carcinogen erachtete Dibenzo [cd,jk] pyrene (Anthanthren) wurde auf seine carcinogene Wirkung in einer vergleichenden Untersuchung mit anderen polycyclischen Kohlenwasserstoffen untersucht. Nach wiederholten Gaben auf die Haut führte Anthanthrene zu gutund bösartigen epidermalen Geschwülsten bei weiblichen Swiss Mäusen. Die Häufigkeit dieser Tumoren (47%) war geringer, und die Latenzzeit war länger als bei Neoplasmen der Haut, die nach Behandlung mit Benzo[a]pyren oder Dibenzo[a,h]pyren gefunden wurden. Da der Anteil bösartiger Geschwülste in diesen drei Behandlungsgruppen ähnlich war (60%), zeigen die Ergebnisse, daß Anthanthren ein relativ starkes Carcinogen ist. Auf eine Erklärung vorher negativer Befunde nach percutaner Behandlung mit dieser Verbindung wird hingewiesen.
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Eppley Institute for Research in Cancer, University of Nebraska Medical Center, 68105, Omaha, Nebraska, USA
E. Cavalieri, P. Mailander & A. Pelfrene
- E. Cavalieri
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- P. Mailander
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- A. Pelfrene
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Supported by U.S. Public Health Service contract 43-68-959 from the Division of Cancer Cause and Prevention, the National Cancer Institute
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Cavalieri, E., Mailander, P. & Pelfrene, A. Carcinogenic activity of anthanthrene on mouse skin.Z. Krebsforsch.89, 113–118 (1977). https://doi.org/10.1007/BF00308512
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