Rhag Rhesus blood group-associated A glycoprotein [Mus musculus (house mouse) ]

Gene ID: 19743, updated on 8-Mar-2025

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Gene Sequences (FASTA)

Transcript sequences (FASTA)

Protein sequences(FASTA)

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Summary

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Official Symbol: Rhagprovided byMGI
Official Full Name: Rhesus blood group-associated A glycoproteinprovided byMGI
Primary source: MGI:MGI:1202713
See related: Ensembl:ENSMUSG00000023926 AllianceGenome:MGI:1202713
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rh50; CD241; Rh50A
Summary: Enables ammonium channel activity and methylammonium transmembrane transporter activity. Involved in methylammonium transmembrane transport. Acts upstream of or within ammonium transmembrane transport; erythrocyte development; and multicellular organismal-level iron ion homeostasis. Predicted to be located in membrane. Predicted to be part of ankyrin-1 complex. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; cerebral cortex; liver; and spleen. Human ortholog(s) of this gene implicated in Rh deficiency syndrome; hemolytic anemia; and overhydrated hereditary stomatocytosis. Orthologous to human RHAG (Rh associated glycoprotein). [provided by Alliance of Genome Resources, Mar 2025]
Expression: Biased expression in liver E14 (RPKM 97.3), liver E14.5 (RPKM 95.7) and 2 other tissuesSee more
Orthologs: human all
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Genomic context

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See Rhag inGenome Data Viewer

Location:: 17 B2; 17 19.54 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (41121990..41154985)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (40811099..40844094)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject:PRJNA66167
Publication:PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Review. Rhag plays a major role in the NH3 conductance of erythrocytes, but probably not in CO2 transport.
Title: Role of RhAG and AQP1 in NH3 and CO2 gas transport in red cell ghosts: a stopped-flow analysis.
RhAG expression enhanced the ammonium-induced initial alkalinization (related to NH3 influx)& secondary acidification (related to NH4+ influx). Sub-millimolar NH4+ concentrations induced inward currents in voltage-clamped RhAG-expressing cells.
Title: The challenge of understanding ammonium homeostasis and the role of the Rh glycoproteins.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (1) 1 citation

General gene information

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Markers

AF057526 (e-PCR)
- UniSTS:163588

Rhag (e-PCR), detects polymorphism
- UniSTS:507190

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ammonium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ammonium channel activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ammonium channel activity	ISO Inferred from Sequence Orthology more info
enables ammonium channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables ankyrin binding	IEA Inferred from Electronic Annotation more info
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables carbon dioxide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables carbon dioxide transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables leak channel activity	ISO Inferred from Sequence Orthology more info
enables leak channel activity	ISS Inferred from Sequence or Structural Similarity more info
enables methylammonium transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables methylammonium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables methylammonium transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in ammonium homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in ammonium transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ammonium transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in ammonium transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbon dioxide transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in carbon dioxide transport	ISO Inferred from Sequence Orthology more info
involved_in carbon dioxide transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within erythrocyte development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inorganic cation transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in inorganic cation transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in intracellular monoatomic ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular monoatomic ion homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in methylammonium transmembrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in methylammonium transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in methylammonium transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ankyrin-1 complex	IEA Inferred from Electronic Annotation more info
part_of ankyrin-1 complex	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: ammonium transporter Rh type A

Names: 50 kD glycoprotein; erythrocyte membrane glycoprotein Rh50; rh family type A glycoprotein; rhesus blood group family type A glycoprotein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds.Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported inGenomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011269.2 →NP_035399.1 ammonium transporter Rh type A
See identical proteins and their annotated locations for NP_035399.1
Status: VALIDATED
Source sequence(s)
AC121932
Consensus CDS
CCDS28787.1
UniProtKB/Swiss-Prot
Q3UP27,Q794G1,Q9QUT0
UniProtKB/TrEMBL
O88299
Related
ENSMUSP00000024721.8,ENSMUST00000024721.8
Conserved Domains (1)summary
pfam00909
Location:15 →410
Ammonium_transp; Ammonium Transporter Family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build.Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCm39 C57BL/6J

Genomic

NC_000083.7 Reference GRCm39 C57BL/6J
Range
41121990..41154985
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GenBank,FASTA,Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006523913.3 →XP_006523976.1 ammonium transporter Rh type A isoform X2
UniProtKB/TrEMBL
A0A3B2WBH6,O88299
Related
ENSMUSP00000156889.2,ENSMUST00000233740.2
Conserved Domains (1)summary
cl03012
Location:16 →390
Ammonium_transp; Ammonium Transporter Family
XM_006523912.2 →XP_006523975.1 ammonium transporter Rh type A isoform X1
UniProtKB/TrEMBL
O88299
Conserved Domains (1)summary
cl03012
Location:16 →391
Ammonium_transp; Ammonium Transporter Family