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keaven/simtrial

 
 

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Installation

You can install from GitHub:

remotes::install_github("Merck/simtrial")

Overview

simtrial is a small package built initially to focus on evaluating weighted logrank tests and combination tests based on such tests. The intent is to usetidyverse (data wrangling) programming procedures and to have a package that is easy to qualify for use in a regulated environment.

Initial areas of focus are:

  • Generating time-to-event data for stratified trials using piecewise constant enrollment and piecewise exponential failure rates. Both proportional and non-proportional hazards are supported.Under proportional hazards, the assumptions are along the lines of those used by Lachin and Foulkes as implemented in thegsDesign for deriving group sequential designs.
  • Setting up data cutoffs for (interim and final) analyses.
  • Support for weighted logrank tests with arbitrary weighting schemes, specifically supporting the Fleming-Harrington set of tests, including the logrank test.

Future developments

Expectations for future development include:

  • Provide a test suite to document that the package is fit for use in a regulatory environment.
  • Further examples.

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