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Operation Mapping of amino acid residues/nucleotides#844
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I could not find an operation for the mapping of residues from one database to another (the mapping likeSIFTS). This is especially the case for mapping residues between UniProt and PDB. |
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Replies: 3 comments 1 reply
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Thanks for bringing this up. Is it mapping sequences between databases through similarity or using ids to map between entries in the different databases? From what I see in your example, the connection between PDB and UniProt is given by the sequence AND the position on the sequence. These are kind of automatically mapped by having the sequences matched. More precisely, what would be the actual computational method in this case ? |
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I will try to explain in a short example to be clear and more precise. One clear example of this is2EK1. Thechain A from the structure hasProline (P) at the875th position. The same residue in UniProt id for the corresponding protein isQ9NTZ6, and the corresponding residue is at the855th position. |
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Your detailed description is superuseful! If I understand correctly, this involves a) mapping the sequences between UniProt and PDB to create the links between the IDs (EDAM operation "ID mapping") and then b) linking the residues between the aligned sequences. The latter indeed does not seem to have a corresponding entry in EDAM. The question is how relevant this operation will be. If you envision that there will be many (>10) tools using this operation, then a new entry will be great. In this case, could you give it a try creating a new issue? The operation template helps providing the details. |
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The usage of this operation depends on the developer of the tool. It is quite common in structural bioinformatics to analyze structure-sequence relationships. |
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