1903 November 2, S. G. Hedin, “On the presence of a proteolytic enzyme in the normal serum of the ox”, inThe Journal of Physiology, volume30, number 2, page195:
As a matter of fact the caseinprotease digests boiled and coagulated serum far more easily than unboiled serum, as set forth by the following experiments.
1948 September 20, Margaret R. McDonald, “A method for the preparation of "protease-free" crystalline ribonuclease”, inJournal of General Physiology, volume32, number 1, page39:
All were tested for their ability to clot milk and to hydrolyze denatured hemoglobin, egg albumin, protamine (salmon), histone (calf thymus), and benzoyl-l-arginineamide. In no case was any trace ofprotease activity detected.
2015, Raja Sivamani, Jared R. Jagdeo, Peter Elsner,Cosmeceuticals and Active Cosmetics:
For our purposes, it is sufficient to note that dysregulation of desquamatoryprotease activity in the SC is often involved in conditions of compromised skin barrier.
