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Zelandopam

From Wikipedia, the free encyclopedia
Abandoned D1-like receptor agonist
Pharmaceutical compound
Zelandopam
Clinical data
Other namesSelandopam; (–)-(S)-7,8-Dihydroxy-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline; 7,8-DDPTI; YM-435; YM435; MYD-37; MYD37
Routes of
administration
Intravenous administration
Drug classDopamineD1-like receptoragonists
Identifiers
  • (4S)-4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline-7,8-diol
CAS Number
PubChemCID
ChemSpider
UNII
ChEMBL
CompTox Dashboard(EPA)
Chemical and physical data
FormulaC15H15NO4
Molar mass273.288 g·mol−1
3D model (JSmol)
  • C1[C@H](C2=C(CN1)C(=C(C=C2)O)O)C3=CC(=C(C=C3)O)O
  • InChI=1S/C15H15NO4/c17-12-3-1-8(5-14(12)19)10-6-16-7-11-9(10)2-4-13(18)15(11)20/h1-5,10,16-20H,6-7H2/t10-/m0/s1
  • Key:FULLEMQICAKPOE-JTQLQIEISA-N

Zelandopam (INNTooltip International Nonproprietary Name; developmental code namesYM-435,MYD-37) is aselectivedopamineD1-like receptoragonist related tofenoldopam which was under development inJapan for the treatment ofhypertension andheart failure but was never marketed.[1][2][3] The drug was being developed for use byintravenous administration.[1] The development of zelandopam appears to have been discontinued by the early 2000s.[1] It was first described in thescientific literature by 1991.[4]

References

[edit]
  1. ^abc"Zelandopam hydrochloride".AdisInsight. 22 May 2002. Retrieved21 October 2024.
  2. ^Doggrell SA (May 2002). "The therapeutic potential of dopamine modulators on the cardiovascular and renal systems".Expert Opin Investig Drugs.11 (5):631–644.doi:10.1517/13543784.11.5.631.PMID 11996645.
  3. ^Vaz de Castro PA, Jose PA, Simões e Silva AC (August 2022). "Interactions between the intrarenal dopaminergic and the renin-angiotensin systems in the control of systemic arterial pressure".Clin Sci (Lond).136 (16):1205–1227.doi:10.1042/CS20220338.PMID 35979889.
  4. ^Giammattei, C. E., Handa, R. K., & Strandhoy, J. W. (1991). The DA1 agonists, YM435 (YM) and fenoldopam (F), inhibit oxygen consumption (QO2) in rat renal proximal tubules. Pharmacologist, 33, 210p.https://scholar.google.com/scholar?cluster=13521937496129958590
D1-like
Agonists
PAMs
Antagonists
D2-like
Agonists
Antagonists


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