It flows within thePodolian Upland starting from the Avratinian Upland. Upon the river are situated a couple of small Hydro Electric Stations (Bodnariv's and Martynkiv's), while along the river are some 140 ponds. The river serves as a natural border betweenTernopil andKhmelnytskyi regions. As it was mentioned above, the river flows through the Podolia Upland sneaking past the Podolian hills also known asMedobory for their honey-bearing flora (literally: Med - honey and Bory - forests). Along the river, there are recreational areas for swimming in the water. Medobory stretches from the northeastern part of theLviv Region to the northern borders of the Republic ofMoldova. The Zbruch, at its mouth, has a width of some 18 m (59 ft). The source of the river lies in relative proximity to other rivers such as the Horyn and the Sluch and used to serve as an alternative route for the tradeway "From the Varangians to Greeks". Presumably the earliest name for the river wasBoruch.
The Zbruch had international significance following thefirst partition of Poland when between 1772 and 1793 the river was a border betweenPoland-Lithuania andHabsburg monarchy. After thesecond partition of Poland in 1793–1807 and 1815–1918 the river was a border between theAustrianGalicia on one side andImperial Russia on the other. During that time the river was also calledPidhirtsi. Following the Polish-Ukrainian Alliance of 1920 it was intended as the border betweenPoland andUkraine. After theTreaty of Riga the Polish-Soviet border was established in the area, running along the river (this situation lasted until 1939).