Protein-coding gene in the species Homo sapiens
Zinc finger protein 43 is aprotein that in humans is encoded by theZNF43 gene .[ 5] [ 6]
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions.[ 6]
Huebner K, Druck T, Croce CM, Thiesen HJ (Apr 1991)."Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering" .American Journal of Human Genetics .48 (4):726– 40.PMC 1682948 PMID 2014798 . Bellefroid EJ, Poncelet DA, Lecocq PJ, Revelant O, Martial JA (May 1991)."The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins" .Proceedings of the National Academy of Sciences of the United States of America .88 (9):3608– 12.Bibcode :1991PNAS...88.3608B .doi :10.1073/pnas.88.9.3608 PMC 51501 PMID 2023909 . Thiesen HJ (Apr 1990). "Multiple genes encoding zinc finger domains are expressed in human T cells".The New Biologist .2 (4):363– 74.PMID 2288909 . Bellefroid EJ, Marine JC, Ried T, Lecocq PJ, Rivière M, Amemiya C, Poncelet DA, Coulie PG, de Jong P, Szpirer C (Apr 1993)."Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells" .The EMBO Journal .12 (4):1363– 74.doi :10.1002/j.1460-2075.1993.tb05781.x .PMC 413348 PMID 8467795 . Hartley JL, Temple GF, Brasch MA (Nov 2000)."DNA cloning using in vitro site-specific recombination" .Genome Research .10 (11):1788– 95.doi :10.1101/gr.143000 .PMC 310948 PMID 11076863 . Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (Sep 2000)."Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing" .EMBO Reports .1 (3):287– 92.doi :10.1093/embo-reports/kvd058 .PMC 1083732 PMID 11256614 . Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, Sültmann H, Poustka A (Oct 2004)."From ORFeome to biology: a functional genomics pipeline" .Genome Research .14 (10B):2136– 44.doi :10.1101/gr.2576704 .PMC 528930 PMID 15489336 . Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006)."The LIFEdb database in 2006" .Nucleic Acids Research .34 (Database issue): D415–8.doi :10.1093/nar/gkj139 .PMC 1347501 PMID 16381901 . Takahashi T, Furuchi T, Naganuma A (Dec 2006)."Endocytic Ark/Prk kinases play a critical role in adriamycin resistance in both yeast and mammalian cells" .Cancer Research .66 (24):11932– 7.doi :10.1158/0008-5472.CAN-06-3220 PMID 17178891 . This article incorporates text from theUnited States National Library of Medicine , which is in thepublic domain .
(1) Basic domains
(1.1) Basic leucine zipper (bZIP )(1.2) Basic helix-loop-helix (bHLH )
Group A Group B Group CPAS Group D Group E Group F
(1.3) bHLH-ZIP (1.4) NF-1 (1.5) RF-X (1.6) Basic helix-span-helix (bHSH)
(2.1) Nuclear receptor (Cys4 )
subfamily 1 subfamily 2 subfamily 3 subfamily 4 subfamily 5 subfamily 6 subfamily 0
(2.2) Other Cys4 (2.3) Cys2 His2 (2.4) Cys6 (2.5) Alternating composition (2.6) WRKY
(4)β-Scaffold factors with minor groove contacts
(0) Other transcription factors
