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ZNF239

From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
ZNF239
Identifiers
AliasesZNF239, HOK-2, MOK2, zinc finger protein 239
External IDsOMIM:601069;MGI:1306812;HomoloGene:68480;GeneCards:ZNF239;OMA:ZNF239 - orthologs
Gene location (Human)
Chromosome 10 (human)
Chr.Chromosome 10 (human)[1]
Chromosome 10 (human)
Genomic location for ZNF239
Genomic location for ZNF239
Band10q11.21Start43,556,344bp[1]
End43,574,618bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for ZNF239
Genomic location for ZNF239
Band6 F1|6 55.62 cMStart117,862,100bp[2]
End117,873,291bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • endothelial cell

  • testicle

  • ganglionic eminence

  • ventricular zone

  • body of pancreas

  • islet of Langerhans

  • stromal cell of endometrium

  • prefrontal cortex

  • smooth muscle tissue
Top expressed in
  • Ileal epithelium

  • cingulate gyrus

  • CA3 field

  • superior frontal gyrus

  • dentate gyrus

  • entorhinal cortex

  • primary visual cortex

  • primary motor cortex

  • perirhinal cortex

  • dentate gyrus of hippocampal formation granule cell
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo /QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8187

22685

Ensembl

ENSG00000196793

ENSMUSG00000042097

UniProt

Q16600

P24399

RefSeq (mRNA)
NM_001099282
NM_001099283
NM_001099284
NM_005674
NM_001324347

NM_001324348
NM_001324349
NM_001324350
NM_001324351
NM_001324352
NM_001324353

NM_001001792
NM_008616
NM_001360938

RefSeq (protein)
NP_001092752
NP_001092753
NP_001092754
NP_001311276
NP_001311277

NP_001311278
NP_001311279
NP_001311280
NP_001311281
NP_001311282
NP_005665

NP_001001792
NP_032642
NP_001347867

Location (UCSC)Chr 10: 43.56 – 43.57 MbChr 6: 117.86 – 117.87 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein 239 is aprotein that in humans is encoded by theZNF239gene.[5][6][7]

Function

[edit]

MOK2 proteins are DNA- and RNA-binding proteins that are mainly associated with nuclear RNP components, including the nucleoli and extranucleolar structures.[7][8]

Interactions

[edit]

ZNF239 has been shown tointeract withLMNA.[9]

References

[edit]
  1. ^abcGRCh38: Ensembl release 89: ENSG00000196793 –Ensembl, May 2017
  2. ^abcGRCm38: Ensembl release 89: ENSMUSG00000042097 –Ensembl, May 2017
  3. ^"Human PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^"Mouse PubMed Reference:".National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^Arranz V, Kress M, Ernoult-Lange M (Jan 1996). "Localization of zinc finger Mok2 gene to mouse chromosome 6, a new region of homology with human chromosome 19".Mammalian Genome.7 (1):77–8.doi:10.1007/s003359900020.PMID 8903737.S2CID 36851320.
  6. ^Ernoult-Lange M, Arranz V, Le Coniat M, Berger R, Kress M (Dec 1995). "Human and mouse Krüppel-like (MOK2) orthologue genes encode two different zinc finger proteins".Journal of Molecular Evolution.41 (6):784–94.Bibcode:1995JMolE..41..784E.doi:10.1007/bf00173158.PMID 8587123.S2CID 22955858.
  7. ^ab"Entrez Gene: ZNF239 zinc finger protein 239".
  8. ^Arranz V, Harper F, Florentin Y, Puvion E, Kress M, Ernoult-Lange M (Apr 1997)."Human and mouse MOK2 proteins are associated with nuclear ribonucleoprotein components and bind specifically to RNA and DNA through their zinc finger domains".Molecular and Cellular Biology.17 (4):2116–26.doi:10.1128/mcb.17.4.2116.PMC 232059.PMID 9121460.
  9. ^Dreuillet C, Tillit J, Kress M, Ernoult-Lange M (Nov 2002)."In vivo and in vitro interaction between human transcription factor MOK2 and nuclear lamin A/C".Nucleic Acids Research.30 (21):4634–42.doi:10.1093/nar/gkf587.PMC 135794.PMID 12409453.

Further reading

[edit]

\*Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006)."Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes".Genome Research.16 (1):55–65.doi:10.1101/gr.4039406.PMC 1356129.PMID 16344560.

External links

[edit]

This article incorporates text from theUnited States National Library of Medicine, which is in thepublic domain.


(1) Basic domains
(1.1) Basicleucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3)bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2)Zinc finger DNA-binding domains
(2.1)Nuclear receptor(Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3.1)Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3)Fork head /winged helix
(3.4)Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4)β-Scaffold factors with minor groove contacts
(4.1)Rel homology region
(4.2)STAT
(4.3) p53-like
(4.4)MADS box
(4.6)TATA-binding proteins
(4.7)High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3)Pocket domain
(0.5)AP-2/EREBP-related factors
(0.6) Miscellaneous


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