Japanese cell biologist
Yoshinori Ohsumi (大隅 良典 Ōsumi Yoshinori is a Japanesecell biologist specializing inautophagy , the process that cells use to destroy and recycle cellular components. Ohsumi is a professor atInstitute of Science Tokyo 's Institute of Innovative Research.[ 1] Kyoto Prize for Basic Sciences in 2012,[ 2] Nobel Prize inPhysiology or Medicine , and the 2017Breakthrough Prize in Life Sciences[ 3] [ 4]
Ohsumi addressed atGairdner Foundation International Award Ceremony (at theRoyal Ontario Museum in October 2015) withJohn Dirks , Kenjirō Monji andD. Lorne Tyrrell Ohsumi was born on February 9, 1945, inFukuoka . He received aB.Sci. in 1967 and a D.Sci. in 1974, both from theUniversity of Tokyo . In 1974–77 he was apostdoctoral fellow at theRockefeller University in New York City.[ 1]
He returned to the University of Tokyo in 1977 as aresearch associate ; he was appointed Lecturer there in 1986, and promoted to Associate Professor in 1988. In 1996, he moved to theNational Institute for Basic Biology, Japan inOkazaki City , where he was appointed as a professor. From 2004 to 2009, he was also professor at theGraduate University for Advanced Studies inHayama . In 2009, he transitioned to a three-way appointment as anemeritus professor at the National Institute for Basic Biology and at theGraduate University for Advanced Studies , and a professorship at the Advanced Research Organization, Integrated Research Institute,Tokyo Institute of Technology (Tokyo Tech). After his retirement in 2014, he continued to serve as Professor at Institute of Innovative Research, Tokyo Institute of Technology. Currently, he is head of the Cell Biology Research Unit, Institute of Innovative Research, Tokyo Institute of Technology.[ 5]
Christian de Duve coined the termautophagy in 1963 whereas Ohsumi began his work in 1988. Prior to that time, less than 20 papers per year were published on this subject.[ 6] [ 7] [ 8]
In 2016, he was awarded theNobel Prize in Physiology or Medicine "for his discoveries of mechanisms forautophagy ".[ 9] [ 10] [ 11] Teikyo University of Science , collaborated on his research.[ 12] [ 13]
Ohsumi in his Tokyo Tech lab Source:[ 5]
Selected publications [ edit ] His original findings about autophagy in yeast cells:[ 19]
Follow up with more research on yeast:[ 19]
Others
M Tsukada;Y Ohsumi (October 25, 1993)."Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae" .FEBS Letters 333 (1– 2):169– 74.doi :10.1016/0014-5793(93)80398-E ISSN 0014-5793 .PMID 8224160 .S2CID 46017791 .Wikidata Q27935838 . N Mizushima; T Noda; T Yoshimori; et al. (September 24, 1998). "A protein conjugation system essential for autophagy".Nature 395 (6700):395– 8.Bibcode :1998Natur.395..395M .doi :10.1038/26506 .ISSN 1476-4687 .PMID 9759731 .S2CID 204997310 .Wikidata Q27940154 . Y Kabeya; N Mizushima; T Ueno; et al. (November 1, 2000)."LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing" .The EMBO Journal 19 (21):5720– 8.doi :10.1093/EMBOJ/19.21.5720 .ISSN 0261-4189 .PMC 305793 PMID 11060023 .Wikidata Q24597817 . Y Ichimura; T Kirisako; T Takao; et al. (November 23, 2000). "A ubiquitin-like system mediates protein lipidation".Nature 408 (6811):488– 92.Bibcode :2000Natur.408..488I .doi :10.1038/35044114 .ISSN 1476-4687 .PMID 11100732 .S2CID 4428142 .Wikidata Q27934137 . Y Ohsumi (March 2001). "Molecular dissection of autophagy: two ubiquitin-like systems".Nature Reviews Molecular Cell Biology 2 (3):211– 6.doi :10.1038/35056522 .ISSN 1471-0072 .PMID 11265251 .S2CID 38001477 .Wikidata Q28206420 .Kuma A; Hatano M; Matsui M; et al. (December 23, 2004). "The role of autophagy during the early neonatal starvation period".Nature 432 (7020):1032– 6.Bibcode :2004Natur.432.1032K .doi :10.1038/NATURE03029 .ISSN 1476-4687 .PMID 15525940 .S2CID 4424974 .Wikidata Q29547489 . Sho W Suzuki; Jun Onodera;Yoshinori Ohsumi (2011)."Starvation induced cell death in autophagy-defective yeast mutants is caused by mitochondria dysfunction" .PLOS One 6 (2): e17412.Bibcode :2011PLoSO...617412S .doi :10.1371/JOURNAL.PONE.0017412 ISSN 1932-6203 .PMC 3045454 PMID 21364763 .Wikidata Q27077073 . Takao Hanada; Nobuo N Noda; Yoshinori Satomi; Yoshinobu Ichimura; Yuko Fujioka; Toshifumi Takao; Fuyuhiko Inagaki;Yoshinori Ohsumi (December 28, 2007)."The Atg12-Atg5 conjugate has a novel E3-like activity for protein lipidation in autophagy" .Journal of Biological Chemistry 282 (52):37298– 302.doi :10.1074/JBC.C700195200 ISSN 0021-9258 .PMID 17986448 .Wikidata Q27933717 . Michitaro Shibata; Kazusato Oikawa; Kohki Yoshimoto; et al. (December 24, 2013)."Highly oxidized peroxisomes are selectively degraded via autophagy in Arabidopsis" .The Plant Cell 25 (12):4967– 4983.doi :10.1105/TPC.113.116947 .ISSN 1040-4651 .JSTOR 43190612 .PMC 3903999 PMID 24368788 .Wikidata Q34394370 . Hayashi Yamamoto; Takayuki Shima; Masaya Yamaguchi; et al. (October 6, 2015)."The Thermotolerant Yeast Kluyveromyces marxianus Is a Useful Organism for Structural and Biochemical Studies of Autophagy" .Journal of Biological Chemistry 290 (49):29506– 29518.doi :10.1074/JBC.M115.684233 ISSN 0021-9258 .PMC 4705951 PMID 26442587 .Wikidata Q34497110 . Hayashi Yamamoto; Yuko Fujioka; Sho W Suzuki; et al. (July 11, 2016)."The Intrinsically Disordered Protein Atg13 Mediates Supramolecular Assembly of Autophagy Initiation Complexes" .Developmental Cell 38 (1):86– 99.doi :10.1016/J.DEVCEL.2016.06.015 ISSN 1534-5807 .PMID 27404361 .Wikidata Q27718642 . ^a b Yoshinori Ohsumi'sORCID 0000-0003-2384-2166 ^ Biemiller, Lawrence (November 10, 2012)."Kyoto Prize Is Awarded to 3 Scholars" .The Chronicle of Higher Education Blogs: The Ticker . RetrievedOctober 4, 2016 . ^ "Laureates—Breakthrough Prize" .Breakthrough Prize . RetrievedDecember 5, 2016 .^ "The Nobel Prize in Physiology or Medicine 2016" . The Nobel Foundation. October 3, 2016. RetrievedOctober 3, 2016 .^a b "Yoshinori Ohsumi Biography" . Institute of Innovative Research, Tokyo Institute of Technology. RetrievedOctober 10, 2016 .^ "Yoshinori Ohsumi: What is autophagy? A dynamic cellular recycling process" . Molecular Frontiers Symposium at the Tokyo Institute of Technology, Japan. October 2017. RetrievedJanuary 15, 2018 .^ Science Staff (October 3, 2016). "Nobel honors discoveries on how cells eat themselves".Science doi :10.1126/SCIENCE.AAH7373 .ISSN 0036-8075 .Wikidata Q57407776 . ^ Klionsky DJ (November 2007). "Autophagy: from phenomenology to molecular understanding in less than a decade".Nature Reviews Molecular Cell Biology 8 (11):931– 7.doi :10.1038/NRM2245 .ISSN 1471-0072 .PMID 17712358 .S2CID 7376303 .Wikidata Q29614174 . ^ "Yoshinori Ohsumi – Nobel Lecture: Autophagy – an Intracellular Recycling System" .Nobel Prize . RetrievedJanuary 15, 2018 .^ Kolata, Gina; Chan, Sewell (October 3, 2016)."Yoshinori Ohsumi of Japan Wins Nobel Prize for Study of 'Self-Eating' Cells" .The New York Times . RetrievedOctober 10, 2016 . ^ Wanklyn, Alastair (October 3, 2016)."Japanese microbiologist Yoshinori Ohsumi wins Nobel in medicine for autophagy research" .The Japan Times . RetrievedOctober 8, 2016 . ^ "大隅萬里子教授の共同研究がノーベル医学・生理学賞として選定されました" [A joint research of Professor Mariko Ohsumi won Nobel Prize in Physiology or Medicine]. Teikyo University of Science. October 5, 2016.^ "Google Scholar" .Scholar.google.com .^ "Yoshinori Ohsumi" .Kyoto Prize . RetrievedOctober 3, 2016 .^ "Yoshinori Ohsumi wins Nobel prize in medicine for work on autophagy" .The Guardian . RetrievedOctober 3, 2016 .^ "The Asian Scientist 100" .Asian Scientist . RetrievedMarch 13, 2025 .^ "Breakthrough Prize – Life Sciences : Breakthrough Prize Laureates – Yoshinori Ohsumi" .Breakthroughprize.org . RetrievedOctober 15, 2018 .^ Yoshinori Ohsumi awarded Honorary Doctorate, delivers special lecture (13 July 2017) | 京都大學 ^a b "Nobel Prize Laureate Yoshinori Ohsumi's Work" . Jstor Daily. October 3, 2016.Yoshinori Ohsumi on Nobelprize.orgMolecular Mechanisms of Autophagy in Yeast
1901–1925 1926–1950 1951–1975 1976–2000 2001–present
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