Y box binding protein 1 also known asY-box transcription factor ornuclease-sensitive element-binding protein 1 is aprotein that in humans is encoded by theYBX1gene.[5] YBX1 is an RNA binding protein[6] that stabilises messenger RNAs modified with N6-methyladenosine.[7]
YBX1 is a potential drug target in cancer therapy.[8] YB-1 helps the replication ofadenovirus type 5, a commonly used vector ingene therapy.[8] Thus, YB-1 can cause an"oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.
Themitochondria of human cells possess a repair pathway forDNAbase pair mismatches that is distinct from theDNA mismatch repair pathway of the nucleus.[9] This mitochondrial pathway includes participation of Y box binding protein 1 (designated YB-1 or YBX1), that likely acts in the mismatch binding and recognition steps of mismatch repair.[9]
^abKojic S, Medeot E, Guccione E, Krmac H, Zara I, Martinelli V, et al. (May 2004). "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle".Journal of Molecular Biology.339 (2):313–325.doi:10.1016/j.jmb.2004.03.071.PMID15136035.
^Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, et al. (January 1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen".Cancer Research.59 (2):342–346.PMID9927044.
^Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ (December 2008). "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1".Journal of Molecular Biology.384 (4):908–916.doi:10.1016/j.jmb.2008.09.060.PMID18851979.
Sakura H, Maekawa T, Imamoto F, Yasuda K, Ishii S (December 1988). "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology".Gene.73 (2):499–507.doi:10.1016/0378-1119(88)90514-8.PMID2977358.
Kudo S, Mattei MG, Fukuda M (July 1995). "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain".European Journal of Biochemistry.231 (1):72–82.doi:10.1111/j.1432-1033.1995.tb20672.x (inactive 13 November 2025).PMID7628487.{{cite journal}}: CS1 maint: DOI inactive as of November 2025 (link)
Toh S, Nakamura T, Ohga T, Koike K, Uchiumi T, Wada M, et al. (January 1998). "Genomic organization of the human Y-box protein (YB-1) gene".Gene.206 (1):93–97.doi:10.1016/S0378-1119(97)00570-2.PMID9461420.
Ise T, Nagatani G, Imamura T, Kato K, Takano H, Nomoto M, et al. (January 1999). "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen".Cancer Research.59 (2):342–346.PMID9927044.
1h95: SOLUTION STRUCTURE OF THE SINGLE-STRANDED DNA-BINDING COLD SHOCK DOMAIN (CSD) OF HUMAN Y-BOX PROTEIN 1 (YB1) DETERMINED BY NMR (10 LOWEST ENERGY STRUCTURES)
