^Glennon RA, Westkaemper RB (1992). "Serotonin Receptors, 5-th Ligands and Receptor Modeling".Pharmacochemistry Library. Vol. 18. Elsevier. pp. 185–207.doi:10.1016/b978-0-444-88931-7.50017-7.ISBN978-0-444-88931-7.Various polycyclic agents such as butaclamol, mianserin, cyproheptadine, pizotyline bind at 5-HT2 receptors with high affinity. These agents are not selective and bind with comparable affinty either at other populations of 5-HT receptors or at other neurotransmitter receptors. Other, structurally unique agents have also been investigated including cinanserin and xylamidine. The latter compound has seen application as a peripheral 5-HT2 antagonist in that it does not readily penetrate the blood-brain barrier; however, xylamidine binds equally well at 5-HTIC and 5-HT2 receptors. See references 3 and 5 for additional information on these types of agents.
^Dave KD, Quinn JL, Harvey JA, Aloyo VJ (March 2004). "Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit".Pharmacol Biochem Behav.77 (3):623–629.doi:10.1016/j.pbb.2003.12.017.PMID15006475.Systemic administration of the peripheral 5-HT2A/2C antagonist xylamidine [...] First, systemic injections of the peripherally acting 5-HT2A/2C receptor antagonist xylamidine were employed to study its effects on head bobs and body shakes produced by systemic injections of DOI.
^Fuller RW, Kurz KD, Mason NR, Cohen ML (June 1986). "Antagonism of a peripheral vascular but not an apparently central serotonergic response by xylamidine and BW 501C67".European Journal of Pharmacology.125 (1):71–7.doi:10.1016/0014-2999(86)90084-1.PMID3732393.
^Dedeoğlu A, Fisher LA (December 1991). "Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms".The Journal of Pharmacology and Experimental Therapeutics.259 (3):1027–34.doi:10.1016/S0022-3565(25)20454-2.PMID1762059.
^Baker BJ, Duggan JP, Barber DJ, Booth DA (May 1988). "Effects of dl-fenfluramine and xylamidine on gastric emptying of maintenance diet in freely feeding rats".European Journal of Pharmacology.150 (1–2):137–42.doi:10.1016/0014-2999(88)90759-5.PMID3402534.
^Dave KD, Quinn JL, Harvey JA, Aloyo VJ (March 2004). "Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit".Pharmacology, Biochemistry, and Behavior.77 (3):623–9.doi:10.1016/j.pbb.2003.12.017.PMID15006475.S2CID25205829.
^WO 2023028086, Kruegel AC, "Combinations of peripheral 5-HT2A receptor antagonists and central 5-HT2A receptor agonists", published 2 March 2023, assigned toGilgamesh Pharmaceuticals, Inc.
