| Year | Title | Role | Director | Notes |
|---|
| 1974 | Los libros | | Ramón Gómez Redondo | TV series (1 Episode) |
| 1976 | Robin and Marian | Queen Isabella | Richard Lester | |
| Storia di arcieri, pugni e occhi neri | Anne Birdsley | Tonino Ricci | |
| 1977 | Change of Sex | José María | Vicente Aranda | |
| Foul Play | Lolita | Juan Antonio Bardem | |
| Esposa y amante | Marisa | Angelino Fons | |
| Doña Perfecta | Rosario | César Fernández Ardavín | |
| Caperucita y Roja | Caperucita | Aitor Goirocelaya & Luis Revenga | |
| Obsesión | Angelines | Francisco Lara Polop | |
| 1978 | El hombre que supo amar | Amelia | Miguel Picazo | |
| 1979 | La barraca | Roseta | León Klimovsky | TV series (9 Episodes) |
| 1980 | Girl with the Golden Panties | Mariana | Vicente Aranda (2) | |
Mieux vaut être riche et bien portant que fauché et mal foutu | Mercedes | Max Pécas | |
| Mater amatísima | Clara | José Antonio Salgot | |
| Le cœur à l'envers | The hostess | Franck Apprederis | |
| 1981 | Comin' at Ya! | Abilene | Ferdinando Baldi | |
| La batalla del porro | Violeta | Joan Minguell | |
| 1982 | Murder in the Central Committee | Carmela | Vicente Aranda (3) | |
| La colmena | Julita | Mario Camus | |
| La guérilléra | Bárbara Périsson | Pierre Kast | |
| La casa del paraíso | Victoria | Santiago San Miguel | |
| Entre paréntesis | Abilene | Simó Fàbregas & Gustavo Montiel Pagés | |
| Estudio 1 | Elena | Miguel Lluch | TV series (1 Episode) |
| 1983 | Moon in the Gutter | Bella | Jean-Jacques Beineix | Nominated –César Award for Best Supporting Actress |
| No Trace of Sin | María da Luz / Lucilia | José Fonseca e Costa | |
| J'ai épousé une ombre | Fifo | Robin Davis | |
| Le bâtard | Betty | Bertrand Van Effenterre | |
| 1984 | Bicycles Are for the Summer | Manolita | Jaime Chávarri | |
| La noche más hermosa | Elena | Manuel Gutiérrez Aragón | Sant Jordi Awards – Best Spanish Actress |
| On the Line | Engracia | José Luis Borau | |
| L'addition | Patty | Denis Amar | Fotogramas de Plata – Best Movie Actress Nominated –César Award for Best Supporting Actress |
| Le voyage | Véronique | Michel Andrieu | |
| Sous le signe du poisson | Antoinette | Pierre Zucca | TV movie |
| 1985 | Padre nuestro | Cardenala | Francisco Regueiro | ADIRCAE Award – Best Performer |
| The Witching Hour | Saga | Jaime de Armiñán | |
| After Darkness | Pascale | Dominique Othenin-Girard & Sergio Guerraz | |
| Rouge-gorge | Marguerite | Pierre Zucca (2) | |
| Los pazos de Ulloa | Nucha / Manolita | Gonzalo Suárez | TV Mini-Series Nominated – Fotogramas de Plata – Best TV Performer |
| La huella del crimen | María Luisa Noguerol | Vicente Aranda (4) | TV series (1 Episode: "Captain Sánchez's Crime") |
| 1986 | Tiempo de Silencio | Dorita | Vicente Aranda (5) | Nominated –Goya Award for Best Actress Nominated – Fotogramas de Plata – Best Movie Actress |
| Max mon amour | Maria | Nagisa Oshima | |
| Nuit d'ivresse | Jugnot's wife | Bernard Nauer | |
| 1987 | El Lute: Run for Your Life | Chelo | Vicente Aranda (6) | San Sebastián International Film Festival – Best Actress TP de Oro – Best Actress ADIRCAE Award – Best Performance Nominated –Goya Award for Best Actress |
| Law of Desire | Girl with Juan | Pedro Almodóvar | |
| Ternosecco | Brigida | Giancarlo Giannini | |
| Uptown | Verónica | José Luis García Berlanga | Fotogramas de Plata – Best Movie Actress |
| 1988 | Without Fear or Blame | Jeanne | Gérard Jugnot | |
| El juego más divertido | Ada / Sara | Emilio Martínez-Lázaro | Nominated – Fotogramas de Plata – Best Movie Actress |
| Baton Rouge | Ana Alonso | Rafael Monleón | Nominated –Goya Award for Best Actress |
| El placer de matar | The Merche | Félix Rotaeta | |
| Ada dans la jungle | Carmen | Gérard Zingg | |
| 1989 | If They Tell You I Fell | Ramona | Vicente Aranda (7) | Fotogramas de Plata – Best Movie Actress Cinematografia de la Generalitat de Catalunya – Best Actress Nominated –Goya Award for Best Actress |
| Tie Me Up! Tie Me Down! | Marina Osorio | Pedro Almodóvar (2) | Nominated –Goya Award for Best Actress Nominated – Fotogramas de Plata – Best Movie Actress |
| 1990 | Sandino [es] | Blanca Arauz | Miguel Littín | Nominated – Fotogramas de Plata – Best Movie Actress |
| A solas contigo | Gloria | Eduardo Campoy | |
| Riders of the Dawn | Marian | Vicente Aranda (8) | TV Mini-Series Festival de Programmes Audiovisuels – Golden FIPA Nominated –TP de Oro – Best Actress |
| La mujer de tu vida | Bel | Emilio Martínez-Lázaro (2) | TV series (1 Episode) |
| 1991 | Lovers | Luisa | Vicente Aranda (9) | Berlin Film Festival Award for Best Actress ADIRCAE Award – Best Actress Turia Award – Best Actress Nominated –Goya Award for Best Actress |
| High Heels | Rebeca Giner | Pedro Almodóvar (3) | Nominated – Fotogramas de Plata – Best Movie Actress |
| Une époque formidable... | Juliette | Gérard Jugnot (2) | |
| 1992 | Demasiado corazón (Too Much Heart) | Ana & Clara Duque | Eduardo Campoy (2) | |
| 1993 | Kika | Andrea Caracortada | Pedro Almodóvar (4) | Association of Latin Entertainment Critics – Best Actress |
| Intruder | Luisa | Vicente Aranda (10) | Nominated – Fotogramas de Plata – Best Movie Actress |
| 1994 | Jimmy Hollywood | Lorraine de la Peña | Barry Levinson | |
| Casque bleu | Alicia | Gérard Jugnot (3) | |
| 1995 | Nobody Will Speak of Us When We're Dead | Gloria Duque | Agustín Díaz Yanes | Goya Award for Best Actress Ondas Award for Best Actress San Sebastián International Film Festival – Best Actress Spanish Actors Union – Film : Lead Performance Nominated – Fotogramas de Plata – Best Movie Actress |
| French Twist | Loli | Josiane Balasko | |
| 1996 | Libertarias | Floren | Vicente Aranda (11) | |
| 1997 | La femme du cosmonaute | Anna | Jacques Monnet | |
| 1999 | Between Your Legs | Miranda | Manuel Gómez Pereira | |
Mon père, ma mère, mes frères et mes sœurs | Anne | Charlotte de Turckheim | |
| 2000 | 101 Reykjavík | Lola Milagros | Baltasar Kormákur | Nominated –Edda Award for Best Leading Actor or Actress |
| 2001 | Don't Tempt Me | Lola Nevado | Agustín Díaz Yanes (2) | Nominated –European Film Award for Best European Actress Nominated –Goya Award for Best Actress Nominated – Fotogramas de Plata – Best Movie Actress Nominated – Spanish Actors Union – Film : Lead Performance |
| Our Tropical Island | Sabina | Marcello Cesena | |
| 2002 | Et après? | Laura | Mohamed Ismail | |
| 2003 | Kaena: The Prophecy | The Queen | Chris Delaporte & Pascal Pinon | |
| 2004 | The 7th Day | Luciana | Carlos Saura | Nominated –Goya Award for Best Supporting Actress Spanish Actors Union – Performance in a Minor Role, Female |
| Cause toujours ! | Jacinthe | Jeanne Labrune | |
| Incautos | Pilar | Miguel Bardem | Fantasporto – Best Actress |
| Escuela de seducción | Sandra Vega | Javier Balaguer | |
| 2005 | Les gens honnêtes vivent en France | Aurore Langlois | Bob Decout | |
| Carne de neón | Pura | Paco Cabezas | Short |
| 2006 | Tirant lo Blanc | Ines | Vicente Aranda (12) | |
| Les aristos | Pilar de Malaga | Charlotte de Turckheim (2) | |
| Summer Rain | The teacher | Antonio Banderas | |
| 2008 | 48 heures par jour | Anna | Catherine Castel | |
| Just Walking | Gloria Duque | Agustín Díaz Yanes (3) | |
| A Day at the Museum | Clara | Jean-Michel Ribes | |
| Leur morale... et la nôtre | Muriel | Florence Quentin | |
| Óscar. Una pasión surrealista | Ana | Lucas Fernández | |
| Mejor que nunca | Isabel Romero | Dolores Payás | |
| 2009 | X Femmes | Her | Blanca Li | TV series (1 Episode) |
| Myster Mocky présente | | Jean-Pierre Mocky | TV series (1 Episode) |
| 2010 | Le grand restaurant | Client | Gérard Pullicino | TV movie |
2010– 18 | Clem | Caroline "Caro" Boissier | Joyce Buñuel, Eric Le Roux & Arnauld Mercadier | TV series (season 1 to 8) |
| 2011 | Hospital Central | La Polaca | José Luis García Berlanga (2) | TV series (1 Episode) Spanish Actors Union – Supporting Performance, Female |
| La chanson du dimanche | Francesca | Alexandre Castagnetti | TV series (1 Episode) |
| Les beaux mecs | Olga | Gilles Bannier | TV series (4 Episodes) |
| 2012 | Mince alors! | Sophie | Charlotte de Turckheim (3) | |
The Woman Who Brushed Off Her Tears | Helena | Teona Strugar Mitevska | |
| 2014–15 | Sin identidad | Fernanda Duque | Joan Noguera, Kiko Ruiz & Jorge Torregrossa | TV series (10 Episodes) Spanish Actors Union – Supporting Performance, Female Nominated – Atv Awards – Best Actress |
| 2016 | Joséphine s'arrondit | Gilles's mother | Marilou Berry | |
| Nacida para ganar | Victoria | Vicente Villanueva | |
| Madres Libres | Candela | Auriane Lacince & Viktoria Videnina | Short |
| Capitaine Marleau | Mother Louise | Josée Dayan | TV series (1 Episode) |